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  4. Recombinant Human Protein GREB1 (GREB1), partial

Recombinant Human Protein GREB1 (GREB1), partial

  • 中文名稱：
    人GREB1重組蛋白
  • 貨號：
    CSB-YP700434HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GREB1重組蛋白
  • 貨號：
    CSB-EP700434HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GREB1重組蛋白
  • 貨號：
    CSB-EP700434HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GREB1重組蛋白
  • 貨號：
    CSB-BP700434HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GREB1重組蛋白
  • 貨號：
    CSB-MP700434HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    GREB1
  • Uniprot No.：
  • 別名：
    5730583K22Rik; 9130004E13; AF180470; AU023194; Gene regulated by estrogen in breast cancer protein; Gene regulated in breast cancer 1 protein; GREB 1; Greb1; GREB1_HUMAN; KIAA0575; mKIAA0575; OTTHUMP00000180581; Protein GREB1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
  • 基因功能參考文獻：
    1. GREB1 is a novel progesterone-responsive gene required for endometrial stromal decidualization. PMID: 28911214
    2. The aim of this study was to determine if genetic variation within GREB1 was associated with BMD variation. PMID: 28293781
    3. Whole exome sequence analysis of two families with renal agenesis identified a single candidate gene, GREB1L. Data implicates GREB1L as a coactivator for RARs. PMID: 28739660
    4. Which were rescued by wild-type human GREB1L mRNA. PMID: 29100090
    5. A significant association between GREB1L variants and BKA. PMID: 29100091
    6. the GREB1 region on chromosome 2p25.1 and the GREB1 gene may play a role in endometriosis risk PMID: 25788566
    7. GREB1 is a critical mediator of both the estrogen-stimulated proliferation of breast cancer cells and the androgen-stimulated proliferation of prostate cancer cells PMID: 24998469
    8. The expression of Greb1 was up-regulated in mouse tumors treated with E2 and was overexpressed in human ovarian cancers relative to human ovarian surface epithelium, suggesting a role for GREB1 in human ovarian tumor progression. PMID: 24469735
    9. RAD54B and GREB1 gene polymorphisms may not be associated with PCOS in the Han Chinese population. PMID: 23876972
    10. GREB1 is one of the central estrogen-specific ER cofactors, where it functions to mediate interactions between the ER and additional proteins. PMID: 23403292
    11. GREB1 alpha mRNA/protein expression levels were increased in ectopic tissue in peritoneal endometriosis. PMID: 22884659
    12. in ER-positive breast cancer cells, LRH-1 promotes cell proliferation by enhancing ERalpha mediated transcription of target genes such as GREB-1 PMID: 22359603
    13. Tissue expression of GREB1 is associated with organ-confined prostate cancer and may constitute a gene associated with a favorable prognosis. PMID: 19945309
    14. Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). PMID: 21577013
    15. Characterize a monoclonal antibody that recognizes GREB1 protein in breast cancer cells. PMID: 19842031
    16. GREB1 is critically involved in the estrogen induced growth of breast cancer cells. PMID: 15986123
    17. GREB1 is expressed in proliferating prostatic tissue and prostate cancer, is regulated by androgens, and suppression of GREB1 blocks androgen-induced growth suggesting GREB1 may be critically involved in prostate cancer proliferation. PMID: 16496412
    18. Data show that the induction of the gene regulated in breast cancer 1 (GREB1) is mediated by binding of estrogen receptor alpha to three consensus estrogen response elements spread over approximately 20 kb of upstream flanking sequences. PMID: 17463000
    19. estrogen-stimulated GREB1 transcription may involve coordinated ER binding to all three distal consensus ERE motifs PMID: 17666587
    20. GREB1 is expressed in human skin, and is dose-dependently induced by topical 17-beta-estradiol treatment PMID: 18794456
    21. Estrogen receptors are recruited at several proximal and distal estrogen response elements upstream of the GREB1 transcription unit. PMID: 15001666

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  • 亞細胞定位：
    Membrane; Single-pass membrane protein.
  • 蛋白家族：
    GREB1 family
  • 組織特異性：
    Expressed in proliferating prostatic tissue and prostate cancer.
  • 數據庫鏈接：

    HGNC: 24885

    OMIM: 611736

    KEGG: hsa:9687

    STRING: 9606.ENSP00000234142

    UniGene: Hs.467733



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