在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein ENL (MLLT1 ENL LTG19 YEATS1)

  • 中文名稱:
  • 貨號:
    CSB-YP2162HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2162HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2162HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP2162HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP2162HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ENL
  • Uniprot No.:
  • 別名:
    Protein ENL; YEATS domain-containing protein 1; MLLT1 ENL LTG19 YEATS1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated. Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20).; Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription.
  • 基因功能參考文獻:
    1. This review will not only provide a fundamental understanding of the structure and function of ENL and update on the roles of ENL in acute myeloid leukemia, but also the development of new therapeutic strategies PMID: 30066088
    2. data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemia PMID: 28241141
    3. Recurrent mutations within Wilms tumours involve the highly conserved YEATS domain of MLLT1. PMID: 26635203
    4. Novel splice isoform of Mllt1 is documented and confirmed that both Mllt1 mRNA isoforms are translated. The data support that MLLT1 protein isoforms display distinct stage-specific expression during spermiogenesis and adult tissues. PMID: 25481096
    5. Data suggest that AT mutated protein ATM-dependent phosphorylation of ENL (MLLT1) protein functions as switch from elongation to Polycomb-mediated repression to preserve genome integrity. PMID: 25921070
    6. AF9 and its homolog ENL directly interact with AF4. PMID: 25509985
    7. MLL-ENL Interaction with CBX8 Is Required for Efficient Transformation. PMID: 23623499
    8. Data from a follow-up study in Rome suggest a particularly favorable prognosis for patients with acute lymphoblastic leukemia expressing the MLL/ENL fusion gene. PMID: 21953510
    9. ENL chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. PMID: 12665591
    10. In acute leukemias with a t(11:19) translocation, 50% of the analyzed breakpoints were within the MLLT1 gene introns. The MLL gene was fused to the intact MLLT1 gene by transcriptional readthrough & a splice event, or by trans-splicing. PMID: 17252016

    顯示更多

    收起更多

  • 相關疾?。?/div>
    A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.
  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 7134

    OMIM: 159556

    KEGG: hsa:4298

    STRING: 9606.ENSP00000252674

    UniGene: Hs.10095



主站蜘蛛池模板: 嫩草欧美曰韩国产大片| 久久超碰色中文字幕超清| 国产97色在线 | 日韩| 国产在线一卡2卡三卡4卡免费| 无码国产激情在线观看| 最新精品国偷自产在线老年人 | 在线看片无码永久免费视频| 不卡无码人妻一区二区三区 | 国产乱人伦中文无无码视频试看| 亚州av综合色区无码一区| 日本亲与子乱人妻hd| 老司机久久99久久精品播放| 欧美性猛交xxxxx按摩欧美| 欧美熟妇色ⅹxxx欧美妇| 少妇被躁爽到高潮无码久久| 亚洲午夜福利av一区二区无码| 日本五月天婷久久网站| 自拍校园亚洲欧美另类| 免费1级做爰片在线观看爱| 国产三级做爰在线播放| 久久国产36精品色熟妇| 久久国内精品自在自线| a∨在线视频播放| 欧美人与动牲交aⅴ| 国产一区二区在线视频| 无码动漫性爽xo视频在线观看| 久久天天躁狠狠躁夜夜2o2o| 欧美日韩亚洲国内综合网| 国产在线 | 中文| 久久国产乱子伦精品免费午夜| 亚洲制服丝袜自拍中文字幕| 亚洲成在人线在线播放无码| 中文字幕人成乱码熟女app| 亚洲综合色噜噜狠狠网站超清| 精品av一区二区久久久| 日本在线视频www色| 亚洲爆乳大丰满无码专区| 欧美精品中文字幕亚洲专区| 久久久99精品成人片| 久久中文字幕无码专区| 老子午夜精品无码不卡|