在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein ENL (MLLT1 ENL LTG19 YEATS1)

  • 中文名稱:
  • 貨號:
    CSB-YP2162HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2162HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2162HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP2162HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP2162HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ENL
  • Uniprot No.:
  • 別名:
    Protein ENL; YEATS domain-containing protein 1; MLLT1 ENL LTG19 YEATS1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated. Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20).; Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription.
  • 基因功能參考文獻:
    1. This review will not only provide a fundamental understanding of the structure and function of ENL and update on the roles of ENL in acute myeloid leukemia, but also the development of new therapeutic strategies PMID: 30066088
    2. data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemia PMID: 28241141
    3. Recurrent mutations within Wilms tumours involve the highly conserved YEATS domain of MLLT1. PMID: 26635203
    4. Novel splice isoform of Mllt1 is documented and confirmed that both Mllt1 mRNA isoforms are translated. The data support that MLLT1 protein isoforms display distinct stage-specific expression during spermiogenesis and adult tissues. PMID: 25481096
    5. Data suggest that AT mutated protein ATM-dependent phosphorylation of ENL (MLLT1) protein functions as switch from elongation to Polycomb-mediated repression to preserve genome integrity. PMID: 25921070
    6. AF9 and its homolog ENL directly interact with AF4. PMID: 25509985
    7. MLL-ENL Interaction with CBX8 Is Required for Efficient Transformation. PMID: 23623499
    8. Data from a follow-up study in Rome suggest a particularly favorable prognosis for patients with acute lymphoblastic leukemia expressing the MLL/ENL fusion gene. PMID: 21953510
    9. ENL chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. PMID: 12665591
    10. In acute leukemias with a t(11:19) translocation, 50% of the analyzed breakpoints were within the MLLT1 gene introns. The MLL gene was fused to the intact MLLT1 gene by transcriptional readthrough & a splice event, or by trans-splicing. PMID: 17252016

    顯示更多

    收起更多

  • 相關疾?。?/div>
    A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.
  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 7134

    OMIM: 159556

    KEGG: hsa:4298

    STRING: 9606.ENSP00000252674

    UniGene: Hs.10095



主站蜘蛛池模板: 久久不见久久见免费影院www| 亚洲国产精品无码久久一区二区| 国产精品偷伦视频观看免费| av大尺度一区二区三区| 精品久久久无码中文字幕 | 暖暖视频 免费 日本社区| 日韩99在线 | 中文| 国语自产偷拍精品视频偷| 情侣作爱视频网站| 日日噜噜夜夜狠狠久久蜜桃| 狠狠躁夜夜躁人人爽天天古典| 18禁无遮挡无码国产免费网站| 亚洲成a v人片在线观看| 婷婷五月综合色视频| 亚洲精品国产嫩草在线观看东京热 | 色一情一伦一区二区三| 亚洲精品久久国产高清小说| 人妻少妇偷人精品视频| 日本欧美大码a在线观看| av高清无码 在线播放| 五 月 丁 香 综合中文| 狠狠躁夜夜躁人人爽天天天天| 人妻少妇av无码一区二区| 无码三级国产三级在线电影| 网禁拗女稀缺资源在线观看| 国产品无码一区二区三区在线| 欧美亚洲国产精品久久蜜芽 | av无码中出一区二区三区| 青青草原综合久久大伊人| 国产产区一二三产区区别在线| 国产白丝无码免费视频| 又大又粗又长的高潮视频| 蜜桃久久精品成人无码av| 久久久久女人精品毛片| 亚洲成av人在线观看天堂无码| 国产高清在线精品一区免费| 欧美 日韩 人妻 高清 中文| 久久香蕉综合色一综合色88| 伊人中文字幕无码专区| 无码av一区二区三区无码| 9420免费高清在线观看视频|