Recombinant Human Protein Dr1 (DR1)

中文名稱：

人DR1重組蛋白
貨號：

CSB-YP007175HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人DR1重組蛋白
貨號：

CSB-EP007175HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人DR1重組蛋白
貨號：

CSB-BP007175HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人DR1重組蛋白
貨號：

CSB-MP007175HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

DR1
Uniprot No.：

Q01658
別名：

Down regulator of transcription 1; Down regulator of transcription 1 TBP binding; Down-regulator of transcription 1; down-regulator of transcription 1; TBP-binding (negative cofactor 2); DR 1; Dr1; Dr1 protein; NC 2; NC2; NC2 beta; NC2-beta; NC2B_HUMAN; Negative co factor 2; Negative cofactor 2; Negative cofactor 2 beta; Negative cofactor 2-beta; Protein Dr1; TATA binding protein associated phosphoprotein; TATA box/binding protein associated phosphoprotein DR1; TATA-binding protein-associated phosphoprotein
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

2-176
氨基酸序列

ASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI SSEANEICNK SEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK RRKASSRLEN LGIPEEELLR QQQELFAKAR QQQAELAQQE WLQMQQAAQQ AQLAAASASA SNQAGSSQDE EDDDDI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
基因功能參考文獻：
1. results suggest that DR1 are expressed in the osteosarcoma cells and inhibit the proliferation of osteosarcoma cells by the down-regulation of the ERK1/2 and PI3K-Akt pathways. PMID: 28181134
2. Knockdown of DR1 resulted in reductions of viral RNA and protein production, demonstrating that DR1 acts as a positive host factor in influenza A virus replication. PMID: 25589657
3. Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells. PMID: 20230619
4. The physiological functions of human Dr1 include regulation of polymerase III transcription. PMID: 19965767
5. NC2 controls TBP binding and maintenance on DNA that is largely independent of a canonical TATA sequence PMID: 15574413
6. the initiator core promoter element antagonizes repression of TATA-directed transcription by negative cofactor NC2 PMID: 17584739
7. Data show that NC2beta is specifically involved in neuroblastoma pathogenesis and may be considered a new neuroblastoma biomarker. PMID: 18538002
8. ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein PMID: 18838386
9. heterodimerization with NC2alpha masks the nuclear localization signal in NC2beta, which prevents nuclear export of the NC2 complex PMID: 19204005
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亞細胞定位：

Nucleus.
蛋白家族：

NC2 beta/DR1 family
數(shù)據(jù)庫鏈接：

HGNC: 3017

OMIM: 601482

KEGG: hsa:1810

STRING: 9606.ENSP00000359290

UniGene: Hs.348418