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  4. Recombinant Human Proteasome subunit beta type-9 (PSMB9)

Recombinant Human Proteasome subunit beta type-9 (PSMB9)

  • 中文名稱：
    人PSMB9重組蛋白
  • 貨號：
    CSB-YP018887HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PSMB9重組蛋白
  • 貨號：
    CSB-EP018887HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PSMB9重組蛋白
  • 貨號：
    CSB-EP018887HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PSMB9重組蛋白
  • 貨號：
    CSB-BP018887HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PSMB9重組蛋白
  • 貨號：
    CSB-MP018887HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PSMB9
  • Uniprot No.：
  • 別名：
    Beta1i; Large multifunctional peptidase 2; Large multifunctional protease 2; LMP 2; LMP2; Low molecular mass protein 2; Macropain chain 7; MGC70470; Multicatalytic endopeptidase complex chain 7; OTTHUMP00000062982; Proteasome (prosome macropain) subunit beta type 9; proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2); Proteasome beta 9 subunit ; Proteasome catalytic subunit 1i; Proteasome chain 7; Proteasome related gene 2; Proteasome subunit beta 6i; Proteasome subunit beta type 9; Proteasome subunit beta type-9; Proteasome subunit beta-1i; PSB9_HUMAN; PSMB 9; PSMB6i; PSMB9; Really interesting new gene 12 protein; RING 12; RING12; RING12 protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    21-219
  • 氨基酸序列
    TTIMAVEFDG GVVMGSDSRV SAGEAVVNRV FDKLSPLHER IYCALSGSAA DAQAVADMAA YQLELHGIEL EEPPLVLAAA NVVRNISYKY REDLSAHLMV AGWDQREGGQ VYGTLGGMLT RQPFAIGGSG STFIYGYVDA AYKPGMSPEE CRRFTTDAIA LAMSRDGSSG GVIYLVTITA AGVDHRVILG NELPKFYDE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
  • 基因功能參考文獻：
    1. Defective PSMB9/beta1i expression is likely to be one of the risk factors for the development of human uterine neoplasm. PMID: 28482675
    2. single nucleotide polymorphism in PSMB9 are associated with hand dermatitis PMID: 27258892
    3. Chinese females carrying the rs17587-G/G genotype in PSMB9 may increase a higher risk for Parkinson's disease. PMID: 27098790
    4. The TAP1-rs1135216 and PSMB9-rs17587 variants are significantly associated with vitiligo, and even one copy of these mutant alleles can influence the risk among Saudis. PMID: 25548428
    5. study found prevalence of LMP2-AA genotype was higher in acute myeolid leukemia (AML) patients while it was significantly lower in multiple myeloma (MM) cases than in the control subjects; results suggestLMP2 polymorphisms could play a role in the development of AML and MM PMID: 24377540
    6. Data indicate that the codon 60 Arg/His polymorphism does not significantly alter the expression and activity of beta1i among the cell lines tested and clinical samples from colon and pancreatic cancer. PMID: 24040045
    7. functional variants in PSMB9 may contribute to melanoma susceptibility. PMID: 23360169
    8. LMP2 has a role as a tumor-suppressor and may have a role in uterine leiomyosarcoma therapy PMID: 22355695
    9. Genetic polymorphisms of rs17587 of PSMB9 appeared to be associated with rheumatoid arthritis in ethnic Han Chinese from Yunnan. PMID: 23568741
    10. study reports expression of LMP2 in patients with renal oncocytomas (RO) and eosinophilic variant of chromophobe renal cell carcinomas (CHRCC-EO); all CHRCC-EO cases (7 of 7) strongly showed nuclear LMP2 staining, as opposed to only 2 of 56 ROs; suggest its use as an aid in differential diagnosis of these neoplasias PMID: 22705098
    11. LMP2 expression in nasopharyngeal carcinoma is associated with poor prognosis. PMID: 22287277
    12. The polymorphic site is unique in the Chinese population of Han nationality at the LMP2 codon 60 loci (Arg60Cys), but a lack of association with lung cancer exists. PMID: 22261389
    13. LMP2 may negatively regulate LMS independently of its role in the proteasome. PMID: 22659265
    14. This is the first study to demonstrate that LMP2 variants can affect radiographic severity in ankylosing spondylitis. PMID: 22034108
    15. Data show that LMP2 60HH variant reduces the risk to develop MS amongst Italian HLA-A*02+ females. PMID: 20174631
    16. downregulation of expression in PBMC of chronic hepatitis B patients PMID: 20300807
    17. data show that the proteasomal ss1i subunit is dysregulated in peripheral white blood cells and in inflammatory infiltrates of minor salivary glands in patients with Sjogren's syndrome PMID: 19833746
    18. a high-frequency TAP1/LMP2 promoter polymorphism in human tumors PMID: 11788900
    19. caspase inhibition led to elevated levels of LMP2 and oxidized proteins; results suggest an age-related loss in capacity to carry out apoptosis might contribute to the observed accumulation of oxidized proteins during aging and in age-related diseases. PMID: 15284441
    20. These data suggest that LMP2 contributes to IkappaBalpha degradation and p50 generation, and that inhibition of LMP2 suppresses expression and activities of MMP-2 and MMP-9 by blocking the transfer of active NF-kappaB heterodimers into the nucleus. PMID: 16222703
    21. LMP2-associated proteasome is recruited to the entire sequence of ER target genes, implicating a role for the proteasome in both transcription initiation and elongation. PMID: 16957778
    22. These data reveal a novel "feed-forward" mechanism induced by NF-kappaB which ensures that acutely synthesized IRF-1 operates in concert with NF-kappaB to amplify the immunoproteasome and antigen-processing functions of CD40. PMID: 18694960
    23. Downregulation of LMP2 is associated with acute myeloid leukaemic blasts. PMID: 19148137
    24. Obtained data suggest the LMP2 and PSMA6 gene polymorphism significance as the risk factors of essential hypertension in adolescents. PMID: 19526842

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1B family
  • 數據庫鏈接：

    HGNC: 9546

    OMIM: 177045

    KEGG: hsa:5698

    STRING: 9606.ENSP00000363993

    UniGene: Hs.654585



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