在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Prolyl 3-hydroxylase 1 (P3H1)

  • 中文名稱:
    Recombinant Human Prolyl 3-hydroxylase 1 (P3H1)
  • 品名簡稱:
    Recombinant Human P3H1 protein
  • 貨號:
    CSB-EP657676HU
  • 說明書:
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Growth suppressor 1;Leucine- and proline-enriched proteoglycan 1;Leprecan-1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    88.1 kDa
  • 表達區域:
    23-736aa
  • 氨基酸序列
    EVESEAGWGMVTPDLLFAEGTAAYARGDWPGVVLSMERALRSRAALRALRLRCRTQCAADFPWELDPDWSPSPAQASGAAALRDLSFFGGLLRRAACLRRCLGPPAAHSLSEEMELEFRKRSPYNYLQVAYFKINKLEKAVAAAHTFFVGNPEHMEMQQNLDYYQTMSGVKEADFKDLETQPHMQEFRLGVRLYSEEQPQEAVPHLEAALQEYFVAYEECRALCEGPYDYDGYNYLEYNADLFQAITDHYIQVLNCKQNCVTELASHPSREKPFEDFLPSHYNYLQFAYYNIGNYTQAVECAKTYLLFFPNDEVMNQNLAYYAAMLGEEHTRSIGPRESAKEYRQRSLLEKELLFFAYDVFGIPFVDPDSWTPEEVIPKRLQEKQKSERETAVRISQEIGNLMKEIETLVEEKTKESLDVSRLTREGGPLLYEGISLTMNSKLLNGSQRVVMDGVISDHECQELQRLTNVAATSGDGYRGQTSPHTPNEKFYGVTVFKALKLGQEGKVPLQSAHLYYNVTEKVRRIMESYFRLDTPLYFSYSHLVCRTAIEEVQAERKDDSHPVHVDNCILNAETLVCVKEPPAYTFRDYSAILYLNGDFDGGNFYFTELDAKTVTAEVQPQCGRAVGFSSGTENPHGVKAVTRGQRCAIALWFTLDPRHSERDRVQADDLVKMLFSPEEMDLSQEQPLDAQQGPPEPAQESLSGSESKPKDEL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.
  • 基因功能參考文獻:
    1. P3H1 mutation is associated with Non-Lethal Type VIII Osteogenesis Imperfecta. PMID: 27383115
    2. This study enhances our knowledge about the mutational pattern of the LEPRE1, CRTAP, and PPIB genes. LEPRE1 should be the first gene analyzed in mutation detection studies in patients with recessive OI. PMID: 26634552
    3. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. PMID: 24043621
    4. This is the first report of a mutation in LEPRE1 that eliminates only the KDEL ER-retrieval sequence, whereas other functional domains remain intact PMID: 22615817
    5. 0.4% of Mid-Atlantic African Americans and 1.48% West Africans carry mutation in LEPRE1 which causes lethal recessive osteogenesis imperfecta. PMID: 22281939
    6. Mutation analyses were performed for COL1A1, COL1A2, CRTAP, and LEPRE1 in a cohort of 58 unrelated Chinese patients with osteogenesis imperfecta. PMID: 21667357
    7. We report a large consanguineous Turkish family in which multiple individuals are affected with autosomal recessive lethal or severe osteogenesis imperfecta (OI) due to a novel homozygous LEPRE1 mutation PMID: 20946018
    8. Null mutations in LEPRE1 and CRTAP cause severe recessive osteogenesis imperfecta. PMID: 19862557
    9. CRTAP and P3H1 are mutually stabilized in the collagen prolyl 3-hydroxylation complex in endoplasmic reticulum. PMID: 19846465
    10. Screening of 78 subjects diagnosed with osteogenesis imperfecta type II or III, identified three probands with mutations in CRTAP and 16 with mutations in LEPRE1. PMID: 18566967
    11. Mutations in CRTAP and LEPRE1 are found in 3 patients with type II osteogenesis imperfecta. PMID: 18996919
    12. Findings suggest that the 3-hydroxylation function of P3H1 is restricted to the 736AA splice form. PMID: 19088120

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Osteogenesis imperfecta 8 (OI8)
  • 亞細胞定位:
    [Isoform 1]: Endoplasmic reticulum.; Secreted, extracellular space, extracellular matrix.
  • 蛋白家族:
    Leprecan family
  • 數據庫鏈接:

    HGNC: 19316

    OMIM: 610339

    KEGG: hsa:64175

    STRING: 9606.ENSP00000296388

    UniGene: Hs.720014



主站蜘蛛池模板: 久热这里只有精品99在线观看| 久久被窝亚洲精品爽爽爽| 人人澡人人妻人人爽人人蜜桃麻豆| 护士奶头又大又软又好摸| 在线精品视频一区二区三区| 久久精品国产色蜜蜜麻豆| 成人免费777777| 成人亚洲欧美一区二区三区| 国产精品久久久久久日本| 亚洲国产精品无码久久| 亚洲熟妇丰满多毛xxxx| 波多野结衣在线精品视频| 免费观看又污又黄在线观看| 成人国产片视频在线观看| 少妇被又大又粗下爽a片| 亚洲精品久久久久久动漫| 国产精品久久久久9999爆乳| 亚洲 日韩 欧美 成人 在线观看| 三级久久试看3分钟| 免费无遮挡在线观看网站| 久久久一本精品99久久精品88| 福利cosplayh裸体の福利| 亚洲国产成人av在线观看| 人人妻人人爽人人做夜欢视频九色| 国产精品久久久久电影网| 国产精品夜色一区二区三区 | 国产精品爆乳在线播放第一人称 | 亚洲欲色欲色xxxxx在线观看| 亚洲成_人网站图片| 在线欧美中文字幕农村电影| 中文字幕欧美日韩va免费视频 | 黄瓜视频在线观看| 成人亚洲欧美久久久久| 欧美成人午夜免费影院手机在线看 | 午夜无码福利伦利理免| 天堂资源在线www在线观看| 久久精品国产丝袜人妻| 国产成人综合亚洲色就色| 国产av影片麻豆精品传媒| 精品免费国产一区二区三区四区介绍 | 亚洲国产成人久久综合碰碰|