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  4. Recombinant Human Probable methyltransferase C20orf7, mitochondrial (C20orf7)

Recombinant Human Probable methyltransferase C20orf7, mitochondrial (C20orf7)

  • 中文名稱：
    人NDUFAF5重組蛋白
  • 貨號：
    CSB-YP713138HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NDUFAF5重組蛋白
  • 貨號：
    CSB-EP713138HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NDUFAF5重組蛋白
  • 貨號：
    CSB-EP713138HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NDUFAF5重組蛋白
  • 貨號：
    CSB-BP713138HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NDUFAF5重組蛋白
  • 貨號：
    CSB-MP713138HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NDUFAF5
  • Uniprot No.：
  • 別名：
    C20orf7; chromosome 20 open reading frame 7; CT007_HUMAN; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5; NDUFAF5; Probable methyltransferase C20orf7; mitochondrial
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    37-345
  • 氨基酸序列
    GSTS PRTLNIFDRD LKRKQKNWAA RQPEPTKFDY LKEEVGSRIA DRVYDIPRNF PLALDLGCGR GYIAQYLNKE TIGKFFQADI AENALKNSSE TEIPTVSVLA DEEFLPFKEN TFDLVVSSLS LHWVNDLPRA LEQIHYILKP DGVFIGAMFG GDTLYELRCS LQLAETEREG GFSPHISPFT AVNDLGHLLG RAGFNTLTVD TDEIQVNYPG MFELMEDLQG MGESNCAWNR KALLHRDTML AAAAVYREMY RNEDGSVPAT YQIYYMIGWK YHESQARPAE RGSATVSFGE LGKINNLMPP GKKSQ
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. Acts by mediating hydroxylation of 'Arg-111' of NDUFS7. May also have methyltransferase activity (Probable).
  • 基因功能參考文獻：
    1. However, similar to another family member, RdmB, it catalyzes the introduction of a hydroxyl group, in the case of NDUFAF5, into Arg-73 in the NDUFS7 subunit of human complex I PMID: 27226634
    2. analysis of the combined OXPHOS complex I and IV defect, due to mutated complex I assembly factor C20ORF7 PMID: 21607760
    3. A new cause of Leigh syndrome can be a defect in early complex I assembly due to C20orf7 mutations. PMID: 19542079
    4. C20orf7 is crucial in the assembly of complex I and mutations in C20orf7 cause mitochondrial disease PMID: 18940309
  • 相關疾病：
    Mitochondrial complex I deficiency (MT-C1D); Leigh syndrome (LS)
  • 亞細胞定位：
    Mitochondrion inner membrane.
  • 蛋白家族：
    Methyltransferase superfamily
  • 數據庫鏈接：

    HGNC: 15899

    OMIM: 252010

    KEGG: hsa:79133

    STRING: 9606.ENSP00000367346

    UniGene: Hs.472165



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