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  4. Recombinant Human RNA-binding protein 20 (RBM20), partial

Recombinant Human RNA-binding protein 20 (RBM20), partial

  • 中文名稱：
    人RBM20重組蛋白
  • 貨號：
    CSB-YP732923HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RBM20重組蛋白
  • 貨號：
    CSB-EP732923HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RBM20重組蛋白
  • 貨號：
    CSB-EP732923HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RBM20重組蛋白
  • 貨號：
    CSB-BP732923HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RBM20重組蛋白
  • 貨號：
    CSB-MP732923HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RBM20
  • Uniprot No.：
  • 別名：
    Probable RNA-binding protein 20; Rbm20; RBM20_HUMAN; RNA binding protein 20; RNA-binding motif protein 20
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin).
  • 基因功能參考文獻：
    1. The first light on molecular mechanisms of RBM20-dependent pathological cardiac remodeling leading to DCM. PMID: 28941705
    2. Mutations in RBM20 cause dilated cardiomyopathy along with dysregulated isoform switch. PMID: 27396593
    3. Heterozygous loss of RBM20 suffices to profoundly impair myocyte biomechanics by its disturbance of TTN splicing causing dilated cardiomyopathy. PMID: 27496873
    4. RBM20 is crucial for the formation of a subset of circular RNAs that originate from the I-band of the titin gene. PMID: 27531932
    5. RBM20 familial dilated cardiomyopathy is a developmental disorder initiated by molecular defects that pattern maladaptive cellular mechanisms of pathological cardiac remodeling. PMID: 26604136
    6. In failing hearts, reduced expression of RBM20 affected alternative splicing of several direct targets, indicating that differences in RBM20 expression may affect cardiac function. PMID: 24960161
    7. Study demonstrates that Rbm20 is expressed in early cardiogenesis and functions in the patterning of cardiac gene expression. PMID: 24584570
    8. The RBM20 c.1907 G>A (p.Arg636His) was confirmed in all 3 affected subjects who underwent exome sequencing. PMID: 23861363
    9. Nuclear retention domains have been identified in RBM20 which is a nuclear protein regulating alternative splicing of expressed genes. PMID: 23886709
    10. Mutations in RBM20 identified in approximately 3% of individuals with dilated cardiomyopathy. Mutations in RBM20 did not adversely affect survival or ventricular arrhythmias in subjects with dilated cardiomyopathy. PMID: 22004663
    11. Deep sequencing of the human and rat cardiac transcriptome revealed an RBM20-dependent regulation of alternative splicing PMID: 22466703
    12. Dilated cardiomyopathy in patients with RBM20 mutations is associated with advanced disease. PMID: 20590677
    13. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    14. RBM20 as a dilated cardiomyopathy gene and reveal a mutation hotspot in the RS domain. Individuals in each family revealed distinct heterozygous missense mutations in exon 9 of RBM20, encoding ribonucleic acid (RNA) binding motif protein 20. PMID: 19712804
    15. RBM20 missense mutation is a novel gene underlying one form of dilated cardiomyopathy PMID: 19712805

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  • 相關疾病：
    Cardiomyopathy, dilated 1DD (CMD1DD)
  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in the heart.
  • 數據庫鏈接：

    HGNC: 27424

    OMIM: 613171

    KEGG: hsa:282996

    STRING: 9606.ENSP00000358532

    UniGene: Hs.116630



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