在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Probable E3 ubiquitin-protein ligase TRIM8 (TRIM8)

Recombinant Human Probable E3 ubiquitin-protein ligase TRIM8 (TRIM8)

  • 中文名稱：
    人TRIM8重組蛋白
  • 貨號：
    CSB-YP871629HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TRIM8重組蛋白
  • 貨號：
    CSB-EP871629HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TRIM8重組蛋白
  • 貨號：
    CSB-EP871629HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TRIM8重組蛋白
  • 貨號：
    CSB-BP871629HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TRIM8重組蛋白
  • 貨號：
    CSB-MP871629HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TRIM8
  • Uniprot No.：
  • 別名：
    AA408830; BB006755; GERP; Glioblastoma-expressed RING finger protein; Lioblastoma expressed ring finger protein; Probable E3 ubiquitin-protein ligase TRIM8; RING finger protein 27; RNF27; RP11-47A8.4; TRIM8; TRIM8_HUMAN; Tripartite motif containing 8; Tripartite motif protein TRIM8; Tripartite motif-containing protein 8
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-551
  • 氨基酸序列
    MAENWKNCFE EELICPICLH VFVEPVQLPC KHNFCRGCIG EAWAKDSGLV RCPECNQAYN QKPGLEKNLK LTNIVEKFNA LHVEKPPAAL HCVFCRRGPP LPAQKVCLRC EAPCCQSHVQ THLQQPSTAR GHLLVEADDV RAWSCPQHNA YRLYHCEAEQ VAVCQYCCYY SGAHQGHSVC DVEIRRNEIR KMLMKQQDRL EEREQDIEDQ LYKLESDKRL VEEKVNQLKE EVRLQYEKLH QLLDEDLRQT VEVLDKAQAK FCSENAAQAL HLGERMQEAK KLLGSLQLLF DKTEDVSFMK NTKSVKILMD RTQTCTSSSL SPTKIGHLNS KLFLNEVAKK EKQLRKMLEG PFSTPVPFLQ SVPLYPCGVS SSGAEKRKHS TAFPEASFLE TSSGPVGGQY GAAGTASGEG QSGQPLGPCS STQHLVALPG GAQPVHSSPV FPPSQYPNGS AAQQPMLPQY GGRKILVCSV DNCYCSSVAN HGGHQPYPRS GHFPWTVPSQ EYSHPLPPTP SVPQSLPSLA VRDWLDASQQ PGHQDFYRVY GQPSTKHYVT S
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction.
  • 基因功能參考文獻：
    1. TRIM8 activates STAT3 by suppressing the expression of PIAS3, an inhibitor of STAT3, most likely through E3-mediated ubiquitination and proteasomal degradation. PMID: 28100038
    2. we provided evidence that TRIM8 and its regulators miR-17-5p and miR-106b-5 participate to a feedback loop controlling cell proliferation through the reciprocal modulation of p53, miR-34a and N-MYC. PMID: 28327152
    3. A pathogenic effect of a heterozygous truncating mutation in the tripartite motif containing 8 (TRIM8) gene on the postnatal development of the human brain. PMID: 27346735
    4. Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. PMID: 26077989
    5. These findings provide the first mechanistic link between TRIM8 and the drug resistance of clear cell Renal Cell Carcinoma PMID: 25277184
    6. Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-kappaB pathway. PMID: 23152791
    7. TRIM8 is a p53 direct target gene that induces p53 stabilization and promotes the degradation of MDM2 protein. PMID: 22262183
    8. Tripartite motif 8 (TRIM8) modulates TNFalpha- and IL-1beta-triggered NF-kappaB activation by targeting TAK1 for K63-linked polyubiquitination. PMID: 22084099
    9. TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90beta and consequently regulates transcription of Nanog in embryonic stem cells. PMID: 21689689
    10. These findings indicate that TRIM8 enhances the STAT3-dependent signal pathway by inhibiting the function of PIAS3. PMID: 20516148
    11. interacts with SOCS-1 PMID: 12163497
    12. Gerp transcribes interferon-gamma in epithelial and lymphoid cells and is expressed almost ubiquitously in tissues. PMID: 15345195
    13. Among genes correlated to nodal metastatic progression, we verified in vitro that NM23-H3 reduced cell motility and TRIM8 were a growth suppressor. PMID: 17900511

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    TRIM/RBCC family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 15579

    OMIM: 606125

    KEGG: hsa:81603

    STRING: 9606.ENSP00000302120

    UniGene: Hs.336810



主站蜘蛛池模板： 精品偷拍被偷拍在线观看| 国产做a爰片久久毛片a片 | 亚洲爆乳www无码专区| 老司机无码精品a| 人人澡人人曰人人摸看| 免费一区二区无码东京热| 国产黄大片在线观看| 精品国产精品久久一区免费式| 在线观看成人年视频免费| 亚洲国产成人爱av网站| 国产精品一卡二卡三卡四卡| 精国产品一区二区三区a片| 欧美肥婆性猛交xxxx| 69国产成人精品午夜福中文| 四虎永久地址www成人| 国产免费一区二区三区免费视频| 亚洲欧美精品综合在线观看| 久久精品中文字幕有码| 人妻少妇精品无码专区动漫| 少妇无套内谢久久久久| 六十熟妇乱子伦视频| 国产一区二区三区无码免费| 女人喷液抽搐高潮视频| 久久影院九九被窝爽爽| 国产乱子伦一区二区三区四区五区 | 中文字幕无线码| 亚洲日韩一区二区一无码| 麻豆国产成人av高清在线观看| 久久精品国产99精品国产亚洲性色| 久久久老熟女一区二区三区| 久久性色欲av免费精品观看| 伊人久久大香线蕉av网| 精品国产乱码久久久久久浪潮| 色婷婷六月亚洲婷婷丁香| 国产人妻久久精品二区三区| 99精品国产一区二区三区不卡| 亚洲精品第一国产综合野草社区| 精品香蕉久久久午夜福利| 人妻系列影片无码专区| 国产色xx群视频射精| 久久亚洲精品国产精品777777|