在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Probable E3 ubiquitin-protein ligase TRIM8 (TRIM8)

Recombinant Human Probable E3 ubiquitin-protein ligase TRIM8 (TRIM8)

  • 中文名稱：
    人TRIM8重組蛋白
  • 貨號：
    CSB-YP871629HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TRIM8重組蛋白
  • 貨號：
    CSB-EP871629HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TRIM8重組蛋白
  • 貨號：
    CSB-EP871629HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TRIM8重組蛋白
  • 貨號：
    CSB-BP871629HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TRIM8重組蛋白
  • 貨號：
    CSB-MP871629HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TRIM8
  • Uniprot No.：
  • 別名：
    AA408830; BB006755; GERP; Glioblastoma-expressed RING finger protein; Lioblastoma expressed ring finger protein; Probable E3 ubiquitin-protein ligase TRIM8; RING finger protein 27; RNF27; RP11-47A8.4; TRIM8; TRIM8_HUMAN; Tripartite motif containing 8; Tripartite motif protein TRIM8; Tripartite motif-containing protein 8
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-551
  • 氨基酸序列
    MAENWKNCFE EELICPICLH VFVEPVQLPC KHNFCRGCIG EAWAKDSGLV RCPECNQAYN QKPGLEKNLK LTNIVEKFNA LHVEKPPAAL HCVFCRRGPP LPAQKVCLRC EAPCCQSHVQ THLQQPSTAR GHLLVEADDV RAWSCPQHNA YRLYHCEAEQ VAVCQYCCYY SGAHQGHSVC DVEIRRNEIR KMLMKQQDRL EEREQDIEDQ LYKLESDKRL VEEKVNQLKE EVRLQYEKLH QLLDEDLRQT VEVLDKAQAK FCSENAAQAL HLGERMQEAK KLLGSLQLLF DKTEDVSFMK NTKSVKILMD RTQTCTSSSL SPTKIGHLNS KLFLNEVAKK EKQLRKMLEG PFSTPVPFLQ SVPLYPCGVS SSGAEKRKHS TAFPEASFLE TSSGPVGGQY GAAGTASGEG QSGQPLGPCS STQHLVALPG GAQPVHSSPV FPPSQYPNGS AAQQPMLPQY GGRKILVCSV DNCYCSSVAN HGGHQPYPRS GHFPWTVPSQ EYSHPLPPTP SVPQSLPSLA VRDWLDASQQ PGHQDFYRVY GQPSTKHYVT S
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction.
  • 基因功能參考文獻：
    1. TRIM8 activates STAT3 by suppressing the expression of PIAS3, an inhibitor of STAT3, most likely through E3-mediated ubiquitination and proteasomal degradation. PMID: 28100038
    2. we provided evidence that TRIM8 and its regulators miR-17-5p and miR-106b-5 participate to a feedback loop controlling cell proliferation through the reciprocal modulation of p53, miR-34a and N-MYC. PMID: 28327152
    3. A pathogenic effect of a heterozygous truncating mutation in the tripartite motif containing 8 (TRIM8) gene on the postnatal development of the human brain. PMID: 27346735
    4. Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. PMID: 26077989
    5. These findings provide the first mechanistic link between TRIM8 and the drug resistance of clear cell Renal Cell Carcinoma PMID: 25277184
    6. Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-kappaB pathway. PMID: 23152791
    7. TRIM8 is a p53 direct target gene that induces p53 stabilization and promotes the degradation of MDM2 protein. PMID: 22262183
    8. Tripartite motif 8 (TRIM8) modulates TNFalpha- and IL-1beta-triggered NF-kappaB activation by targeting TAK1 for K63-linked polyubiquitination. PMID: 22084099
    9. TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90beta and consequently regulates transcription of Nanog in embryonic stem cells. PMID: 21689689
    10. These findings indicate that TRIM8 enhances the STAT3-dependent signal pathway by inhibiting the function of PIAS3. PMID: 20516148
    11. interacts with SOCS-1 PMID: 12163497
    12. Gerp transcribes interferon-gamma in epithelial and lymphoid cells and is expressed almost ubiquitously in tissues. PMID: 15345195
    13. Among genes correlated to nodal metastatic progression, we verified in vitro that NM23-H3 reduced cell motility and TRIM8 were a growth suppressor. PMID: 17900511

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    TRIM/RBCC family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 15579

    OMIM: 606125

    KEGG: hsa:81603

    STRING: 9606.ENSP00000302120

    UniGene: Hs.336810



主站蜘蛛池模板： 99精品无人区乱码在线观看| 影视先锋男人无码在线| 国产精品无码天天爽视频| 国产suv精品一区二区四| 少妇暴力深喉囗交3p| 国产成人精品午夜视频| 久久久国产乱子伦精品| 性xxxx视频播放免费| 日韩精品中文字幕无码一区| 欧美亚洲另类 丝袜综合网| 中国少妇xxxx做受| 乱人伦人妻中文字幕无码久久网 | 无码综合天天久久综合网色吧影院 | 亚洲人av高清无码| 国产精品高清不卡在线播放 | 男女爽爽无遮挡午夜视频| 妺妺窝人体色www婷婷| 妇女性内射冈站hdwww000| 亚洲国产精品第一区二区三区| 又黄又爽的60分钟视频| 国产亚洲精品久久久久久久久动漫| 99在线精品视频在线观看| 男人吃奶摸下挵进去好爽| 久久午夜无码鲁丝片| 蜜桃视频网站| 成人片无码免费播放| 国产在线视频主播区| 92国产精品午夜福利| 亚洲伊人丝袜精品久久| 无码啪啪熟妇人妻区| 久久久久99精品成人片三人毛片| 国产免费无码一区二区视频| 亚洲国产精品久久久天堂不卡海量 | 久青草国产在视频在线观看| 亚洲精品永久在线观看| 一本一道vs无码中文字幕| 蜜臀视频一区二区在线播放| 丰满的少妇xxxxx青青青| 欧美色欧美亚洲另类二区| 亚洲成亚洲成网| 久久99精品久久只有精品|