在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Prickle-like protein 1 (PRICKLE1), partial

  • 中文名稱:
    人PRICKLE1重組蛋白
  • 貨號:
    CSB-YP850396HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PRICKLE1重組蛋白
  • 貨號:
    CSB-EP850396HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人PRICKLE1重組蛋白
  • 貨號:
    CSB-EP850396HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PRICKLE1重組蛋白
  • 貨號:
    CSB-BP850396HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PRICKLE1重組蛋白
  • 貨號:
    CSB-MP850396HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    PRICKLE1; RILPPrickle-like protein 1; REST/NRSF-interacting LIM domain protein 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
  • 基因功能參考文獻:
    1. upregulation of PRICKLE1 in basal breast cancers, a subtype characterized by high metastatic potential, is associated with poor metastasis-free survival. PMID: 27184734
    2. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. PMID: 24312498
    3. study demonstrates that PRICKLE1 could act as a predisposing factor to human neural tube defects PMID: 21901791
    4. MINK1 interacts with and phosphorylates PRICKLE1 and PRICKLE2. PMID: 22037766
    5. Mutations in prickle1 causes seizures. PMID: 21276947
    6. PRICKLE1 mutations are not a frequent cause of progressive myoclous epilepsies in Southern Italy. PMID: 20842693
    7. PRICKLE1 and PRICKLE2 mRNAs were expressed together in brain, eye and testis. PMID: 12525887
    8. appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors PMID: 14645515
    9. NRSF/REST functions as a repressor of TH transcription in NSCs via a mechanism dependent on the TH NRSE/RE1 sites. PMID: 16764822
    10. Prickle-1 is a negative regulator of the Wnt/beta-catenin signaling pathway and is a putative tumor suppressor in human hepatocellular carcinoma PMID: 17030191
    11. there is synergism between REST and NFkappaB in the suppression of TAC1 in non-neuronal cells PMID: 17709376
    12. A homozygous mutation in PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. PMID: 18976727
    13. A physical and functional interaction between Prickle and Strabismus was found in Drosophila and Xenopus, but is likely conserved in human, too. PMID: 12941693

    顯示更多

    收起更多

  • 相關疾病:
    Epilepsy, progressive myoclonic 1B (EPM1B); Neural tube defects (NTD)
  • 亞細胞定位:
    Nucleus membrane. Cytoplasm, cytosol. Note=A smaller amount is detected in the cytosol.
  • 蛋白家族:
    Prickle / espinas / testin family
  • 組織特異性:
    Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia).
  • 數據庫鏈接:

    HGNC: 17019

    OMIM: 182940

    KEGG: hsa:144165

    STRING: 9606.ENSP00000345064

    UniGene: Hs.524348



主站蜘蛛池模板: 丁香激情综合久久伊人久久| 青青草99久久精品国产综合| 国产免费观看久久黄av片| 性高湖久久久久久久久aaaaa| 香港台湾经典三级a视频| 菠萝菠萝蜜午夜视频在线播放观看 | 99热99这里只有高清国产 | 欧美35页视频在线观看| 无套中出丰满人妻无码| 99热久久这里只有精品| 99国产在线精品视频| 亚洲精品综合一区二区| 国产成人精品999在线观看| 精品人伦一区二区三区潘金莲| 亚洲成av人片在www| 日本丰满护士videossexhd| yy111111少妇无码影院| 中文字幕人妻伦伦| 亚洲精品久久国产精品浴池| 老头把我添高潮了a片| 日本三级在线观看免费| 2018年亚洲欧美在线v| 国产男女免费完整视频在线 | 十八18禁国产精品www| 天天天天做夜夜夜夜做无码 | 欧美真人做爰在线观看| 国产熟妇与子伦hd| 国内精品久久久久精免费| 人人超碰人人超级碰国| 国产精品一久久香蕉国产线看观看| 色欲av无码一区二区三区| 亚洲国产中文曰韩丝袜| 香蕉久久精品日日躁夜夜躁夏| 中文字幕无码不卡一区二区三区 | 少妇被爽到高潮在线观看| 2020国产在线拍揄自揄视频| 成品人视频ww入口| 亚洲男女羞羞无遮挡久久丫| 亚洲精品宾馆在线精品酒店| 欧美牲交a欧美牲交aⅴ| 国产成人av大片大片在线播放|