在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Prickle-like protein 1 (PRICKLE1), partial

  • 中文名稱:
    人PRICKLE1重組蛋白
  • 貨號:
    CSB-YP850396HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PRICKLE1重組蛋白
  • 貨號:
    CSB-EP850396HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人PRICKLE1重組蛋白
  • 貨號:
    CSB-EP850396HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PRICKLE1重組蛋白
  • 貨號:
    CSB-BP850396HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PRICKLE1重組蛋白
  • 貨號:
    CSB-MP850396HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    PRICKLE1; RILPPrickle-like protein 1; REST/NRSF-interacting LIM domain protein 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
  • 基因功能參考文獻:
    1. upregulation of PRICKLE1 in basal breast cancers, a subtype characterized by high metastatic potential, is associated with poor metastasis-free survival. PMID: 27184734
    2. these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles. PMID: 24312498
    3. study demonstrates that PRICKLE1 could act as a predisposing factor to human neural tube defects PMID: 21901791
    4. MINK1 interacts with and phosphorylates PRICKLE1 and PRICKLE2. PMID: 22037766
    5. Mutations in prickle1 causes seizures. PMID: 21276947
    6. PRICKLE1 mutations are not a frequent cause of progressive myoclous epilepsies in Southern Italy. PMID: 20842693
    7. PRICKLE1 and PRICKLE2 mRNAs were expressed together in brain, eye and testis. PMID: 12525887
    8. appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors PMID: 14645515
    9. NRSF/REST functions as a repressor of TH transcription in NSCs via a mechanism dependent on the TH NRSE/RE1 sites. PMID: 16764822
    10. Prickle-1 is a negative regulator of the Wnt/beta-catenin signaling pathway and is a putative tumor suppressor in human hepatocellular carcinoma PMID: 17030191
    11. there is synergism between REST and NFkappaB in the suppression of TAC1 in non-neuronal cells PMID: 17709376
    12. A homozygous mutation in PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. PMID: 18976727
    13. A physical and functional interaction between Prickle and Strabismus was found in Drosophila and Xenopus, but is likely conserved in human, too. PMID: 12941693

    顯示更多

    收起更多

  • 相關疾病:
    Epilepsy, progressive myoclonic 1B (EPM1B); Neural tube defects (NTD)
  • 亞細胞定位:
    Nucleus membrane. Cytoplasm, cytosol. Note=A smaller amount is detected in the cytosol.
  • 蛋白家族:
    Prickle / espinas / testin family
  • 組織特異性:
    Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia).
  • 數據庫鏈接:

    HGNC: 17019

    OMIM: 182940

    KEGG: hsa:144165

    STRING: 9606.ENSP00000345064

    UniGene: Hs.524348



主站蜘蛛池模板: 一本大道伊人av久久乱码| 18禁真人抽搐一进一出免费| 国产成人青青久久大片| 久久国产av影片| 性欧美欧美巨大69| 免费夜色污私人影院在线观看| 久久综合给合久久国产免费| 久九九久视频精品免费| 色噜噜狠狠狠狠色综合久| 女人被狂躁c到高潮视频| 国产一二三四区乱码免费| 亚洲深深色噜噜狠狠网站| 久久久久亚洲精品成人网| 日本公妇乱偷中文字幕| 无码精品一区二区三区在线| 欧美激情一区二区成人| 让少妇爽到高潮视频| 少妇激情一区二区三区视频小说| 亚洲国产天堂久久综合| 久久性色欲av免费精品观看| 亚洲情a成黄在线观看| 吃奶呻吟打开双腿做受动态图| 久久/这里只精品热在线获取| 亚洲精品色播一区二区| 99精品无人区乱码1区2区3区 | 亚洲最大成人网站| 美女啪啪网站又黄又免费| 久久成人影院精品99| 国产av综合第一页| 人人妻人人澡人人爽欧美二区| 丰满人妻一区二区三区无码av | 噜噜噜亚洲色成人网站∨| 无码国产精成人午夜视频一区二区| 99久久无色码中文字幕| 免费看国产成年无码av| 日本乱偷人妻中文字幕| 日韩一本之道一区中文字幕| 亚洲精品无码成人片| 女厕厕露p撒尿八个少妇| 中国少妇无码专区| 精产国品一区二区三产区|