在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Polyubiquitin-B (UBB)

Recombinant Human Polyubiquitin-B (UBB)

  • 中文名稱：
    人UBB重組蛋白
  • 貨號(hào)：
    CSB-YP316022HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人UBB重組蛋白
  • 貨號(hào)：
    CSB-EP316022HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人UBB重組蛋白
  • 貨號(hào)：
    CSB-EP316022HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人UBB重組蛋白
  • 貨號(hào)：
    CSB-BP316022HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人UBB重組蛋白
  • 貨號(hào)：
    CSB-MP316022HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    UBB; UBB_HUMAN; Ubiquitin
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-76
  • 氨基酸序列
    MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
  • 基因功能參考文獻(xiàn)：
    1. This study demonstrated that the Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam. PMID: 29122008
    2. The polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB have been characterized. PMID: 27861798
    3. The C-terminal five residues of Ub, RLRGG, are responsible for the interaction with the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease. PMID: 27245450
    4. A new crystallographic structure of human ubiquitin solved from crystals grown in the presence of magnesium. PMID: 26750481
    5. Data suggest that both human ubiquitin and HFBII (hydrophobin-II from Trichoderma reesei) exhibit a critical surface hydration level (or effective hydrophobic interface at the surface) at which percolation transition of water network occurs. PMID: 25204743
    6. UbB was significantly increased in prolonged Trichostatin A-selected HeLa cells and it played a key role in the maintenance of cervical cancer stem-like cells PMID: 24367661
    7. downregulation of ubiquitin through Ubb-KD is a potential anti-cancer treatment by inhibiting ubiquitination at multiple sites related to oncogenic pathways and by weakening the ability of cancer cells to overcome increased stress. PMID: 24022007
    8. A significant decrease in amyloid beta deposition and plaque formation suggests a role for the ubiquitin-proteasome system in the amyloid pathology of Alzheimer's disease. PMID: 22797007
    9. age-dependent accumulation of Ubb(+1) , and how Ubb(+1) -mediated proteasome inhibition may contribute to Alzheimer's disease. [review] PMID: 22082077
    10. Studies indicate that biomedical research on ubiquitin moves into translational research and drug discovery. PMID: 21544573
    11. Studies indicate that DUBs recycle ubiquitin by processing polyubiquitin chains to generate free ubiquitin, and can be regulated by ubiquitination or phosphorylation. PMID: 21480003
    12. analysis of orexin receptor 1 and 2 -arrestin-ubiquitin complexes PMID: 21378163
    13. The results of this study demonstrated that the UBB mutation caused the subtle defect in spatial reference memory formation, caused by a decrease in forebrain proteasome activity. PMID: 21059367
    14. Studies indicate that indicating that the inhibition of the ubiquitin-proteasome system could be used as a novel approach for cancer therapy. PMID: 20491623
    15. Results suggest that the interaction between E2-25K and UBB(+1) is critical for the synthesis and accumulation of UBB(+1)-anchored polyubiquitin, which results in proteasomal inhibition and neuronal cell death. PMID: 20826778
    16. Molecular misreading of the ubiquitin B gene and hepatic mallory body formation. PMID: 12055595
    17. expression of UBB+1 causes proteasome inhibition and induces expression of heat-shock proteins; although UBB+1-expressing cells have a compromised ubiquitin-proteasome system, they are protected against oxidative stress PMID: 12871580
    18. The temporal localization of frame-shift ubiquitin-B and amyloid precursor protein, and complement proteins in the brain of non-demented control patients with increasing Alzheimer's disease pathology. PMID: 12893422
    19. In sporadic inclusion-body myositis, UBB+1 may be pathogenic by inhibiting proteasome, thereby promoting accumulation of cytotoxic misfolded amyloid-beta and phosphorylated-tau. PMID: 15452314
    20. UBB+1, a mutant form of ubiquitin was present in the majority of NFTs, whereas co-existence of alpha-synuclein and UBB+1 was found in only a few neurons in cases of combined multiple system atrophy and Alzheimer's disease. PMID: 17237936
    21. K63-polyubiquitination guards against chemical carcinogenesis by preventing mutagenesis and thus contributing to genomic stability PMID: 17395554
    22. UBB(+1), at low expression levels, is efficiently degraded by the proteasome, but at high levels, the proteasome failed to degrade UBB(+1), causing its accumulation. PMID: 17405812
    23. analyse the expression of mutant ubiquitin (UBB+1), in muscle biopsies from patients suffering from myotilinopathy and desminopathy PMID: 17931355
    24. The expression a mutant human UBB analogous (UB14) in yeast markedly enhanced cellular susceptibility to toxic protein aggregates. PMID: 19214209

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Ubiquitin]: Cytoplasm. Nucleus.
  • 蛋白家族：
    Ubiquitin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12463

    OMIM: 191339

    KEGG: hsa:7314

    STRING: 9606.ENSP00000304697

    UniGene: Hs.356190



主站蜘蛛池模板： 国产精品xxx在线| 国产免费踩踏调教视频| 在线欧美中文字幕农村电影 | 久久国产精品波多野结衣av| 亚洲精品日韩一区二区电影| 国产嘿嘿嘿视频在线观看| 亚洲精品久久久久中文字幕一福利| 柠檬福利第一导航在线| 久久青草费线频观看| 老湿机69福利区18禁网站| 久久久亚洲欧洲日产国码二区| 国产精品久久久爽爽爽麻豆色哟哟| 少妇下面好紧好多水真爽播放| 黑人巨茎大战欧美白妇免费| 国产农村黄aaaaa特黄av毛片 | 美女被啪到深处抽搐视频| 中文字字幕在线成人av电影| 综合 欧美 亚洲日本| 偷偷做久久久久网站| 亚洲日韩a∨无码久| 伊人久久大香线蕉综合75| 国产97在线 | 中文| 亚洲精品夜夜夜妓女网| 亚洲精品伊人久久久大香| 国产综合无码一区二区色蜜蜜| 国产精品久久久久久久久岛| av激情亚洲男人的天堂| 亚洲高清偷拍一区二区三区| 艳妇乳肉豪妇荡乳av无码福利| 狼人亚洲国内精品自在线| 高清国产在线拍揄自揄视频| 亚洲色成人中文字幕网站| 西西人体大胆午夜啪啪| 永久免费无码网站在线观看个| www成人国产高清内射| 中文在线最新版天堂| 欧美日韓性视頻在線| 亚洲日韩欧美在线成人| 国产真人做爰毛片视频直播| 国产成人综合95精品视频 | 2021无码最新国产在线观看|