Recombinant Human Pleckstrin homology domain-containing family N member 1 (PLEKHN1)

中文名稱：

人PLEKHN1重組蛋白
貨號：

CSB-YP672075HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人PLEKHN1重組蛋白
貨號：

CSB-EP672075HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人PLEKHN1重組蛋白
貨號：

CSB-EP672075HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PLEKHN1重組蛋白
貨號：

CSB-BP672075HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人PLEKHN1重組蛋白
貨號：

CSB-MP672075HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

PLEKHN1
Uniprot No.：

Q494U1
別名：

PLEKHN1; CLPABP; Pleckstrin homology domain-containing family N member 1; PH domain-containing family N member 1; Cardiolipin and phosphatidic acid-binding protein
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區(qū)域：

1-663
氨基酸序列

MGNSHCVPQA PRRLRASFSR KPSLKGNRED SARMSAGLPG PEAARSGDAA ANKLFHYIPG TDILDLENQR ENLEQPFLSV FKKGRRRVPV RNLGKVVHYA KVQLRFQHSQ DVSDCYLELF PAHLYFQAHG SEGLTFQGLL PLTELSVCPL EGSREHAFQI TGVWDASRAP RGTPDPGLGE GPALWLRSTC VYVCALSALP AGPLPAPLLV LCPSRAELDR WLYHLEKQTA LLGGPRRCHS APPQGSCGDE LPWTLQRRLT RLRTASGHEP GGSAVCASRV KLQHLPAQEQ WDRLLVLYPT SLAIFSEELD GLCFKGELPL RAVHINLEEK EKQIRSFLIE GPLINTIRVV CASYEDYGHW LLCLRAVTHR EGAPPLPGAE SFPGSQVMGS GRGSLSSGGQ TSWDSGCLAP PSTRTSHSLP ESSVPSTVGC SSQHTPDQAN SDRASIGRRR TELRRSGSSR SPGSKARAEG RGPVTPLHLD LTQLHRLSLE SSPDAPDHTS ETSHSPLYAD PYTPPATSHR RVTDVRGLEE FLSAMQSARG PTPSSPLPSV PVSVPASDPR SCSSGPAGPY LLSKKGALQS RAAQRHRGSA KDGGPQPPDA PQLVSSAREG SPEPWLPLTD GRSPRRSRDP GYDHLWDETL SSSHQKCPQL GGPEASGGLV QWI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol. Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells.
亞細胞定位：

Cell membrane; Lipid-anchor. Mitochondrion. Mitochondrion membrane.
組織特異性：

Ubiquitous. Epressed in several cancer cell lines of differing origin.
數(shù)據(jù)庫鏈接：

HGNC: 25284

KEGG: hsa:84069

UniGene: Hs.528691