Recombinant Human Pleckstrin homology domain-containing family M member 2 (PLEKHM2), partial

中文名稱：

人PLEKHM2重組蛋白
貨號：

CSB-YP814214HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人PLEKHM2重組蛋白
貨號：

CSB-EP814214HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人PLEKHM2重組蛋白
貨號：

CSB-EP814214HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PLEKHM2重組蛋白
貨號：

CSB-BP814214HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人PLEKHM2重組蛋白
貨號：

CSB-MP814214HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

PLEKHM2
Uniprot No.：

Q8IWE5
別名：

PLEKHM2; KIAA0842; SKIP; Pleckstrin homology domain-containing family M member 2; PH domain-containing family M member 2; Salmonella-induced filaments A and kinesin-interacting protein; SifA and kinesin-interacting protein
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.
基因功能參考文獻(xiàn)：
1. The association of PLEKHM2 mutation with dilated cardiomyopathy and left ventricular noncompaction supports the importance of autophagy for normal cardiac function. PMID: 26464484
2. A dynamic process of kinesin recruitment in Salmonella-infected cells is down-regulated by the SifA-mediated recruitment of SKIP on membranes [SKIP] PMID: 15905402
亞細(xì)胞定位：

Cytoplasm. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
數(shù)據(jù)庫鏈接：

HGNC: 29131

OMIM: 609613

KEGG: hsa:23207

STRING: 9606.ENSP00000364956

UniGene: Hs.646775