Recombinant Human Phosphoinositide 3-kinase regulatory subunit 5 (PIK3R5)

中文名稱：

人PIK3R5重組蛋白
貨號：

CSB-EP841225HU
規(guī)格：

￥1344
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

PIK3R5
Uniprot No.：

Q8WYR1
別名：

5-bisphosphate 3-kinase regulatory subunit; F730038I15Rik; FOAP 2; FOAP2; OTTHUMP00000135339; p101; P101 PI3K; p101-PI3K; Phosphatidylinositol 4; Phosphatidylinositol 4,5 bisphosphate 3 kinase regulatory subunit; Phosphoinositide 3 kinase, regulatory subunit 5; Phosphoinositide 3 kinase, regulatory subunit 5, p101; Phosphoinositide 3 kinase, regulatory subunit, polypeptide p101; Phosphoinositide 3-kinase regulatory subunit 5; PI3 kinase p101 subunit; PI3 kinase regulatory subunit 5; PI3-kinase p101 subunit; PI3-kinase regulatory subunit 5; PI3R5_HUMAN; PIK3 R5; PIK3R5; Protein FOAP 2; Protein FOAP-2; PtdIns 3 kinase p101; PtdIns 3 kinase regulatory subunit; PtdIns-3-kinase p101; PtdIns-3-kinase regulatory subunit
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Isoform 2
來源：

E.coli
分子量：

70.9kDa
表達區(qū)域：

1-494aa
氨基酸序列

MDSGYVEDSEESSSEWPWRRGSQERRGHRRPGQKFIRIYKLFKSTSQLVLRRDSRSLEGSSDTALPLRRAGSLCSPLDEPVSPPSRAQRSRSLPQPKLGTQLPSWLLAPASRPQRRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLRRLENNRPLLTRFFKLQFFYVPVKRSHGTSPGACPPPRSQTPSPPTDSPRHASPGELGTTPWEESTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKAEAQALEGSPTQLPILADMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHSAATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVVKRQNSKSKKGFNQISTSQIKVDKVQIIGSNSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAQAAPDLCSLLCLPIMTFSGALP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-SUMO-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.
基因功能參考文獻：
1. data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma activation. PMID: 26173259
2. PIK3R5 promoter hypermethylation is associated with oral squamous cell carcinoma. PMID: 25374236
3. expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. PMID: 24014027
4. Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis. PMID: 22065524
5. p101 has a role in membrane recruitment and activation of PI3K gamma PMID: 12507995
6. analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma PMID: 15611065
7. Overexpression of p101 activates PI3Kgamma signaling and is associated with T-cell lymphomas PMID: 17486067
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相關(guān)疾病：

Ataxia-oculomotor apraxia 3 (AOA3)
亞細胞定位：

Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
組織特異性：

Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
數(shù)據(jù)庫鏈接：

HGNC: 30035

OMIM: 611317

KEGG: hsa:23533

STRING: 9606.ENSP00000392812

UniGene: Hs.278901