在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B)

In Stock
  • 中文名稱:
    人PIP4K2B重組蛋白
  • 貨號:
    CSB-EP018023HU
  • 規(guī)格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta)(Diphosphoinositide kinase 2-beta)(Phosphatidylinositol 5-phosphate 4-kinase type II beta)(PI(5)P 4-kinase type II beta)(PIP4KII-beta)(PtdIns(5)P-4-kinase isoform 2-beta)
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    53.3 kDa
  • 表達(dá)區(qū)域:
    2-416aa
  • 氨基酸序列
    SSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.
  • 基因功能參考文獻(xiàn):
    1. PIP4K2B couples the cellular GTP concentration to the levels of the stress-regulated phosphoinositide PtdIns5P, to impact on tumor cell growth. PMID: 27132569
    2. Suppression of PIP4K expression selectively prevents tumor cell growth in vitro and prevents tumor development in mice that have lost the tumor suppressor p53. (Review) PMID: 25728392
    3. Association between low PIP4K2B expression and poor patient survival.Analysis of gene expression datasets confirmed the association between low PIP4K2B and low CDH1expression. PMID: 24127122
    4. Knocking down PI5P4Kalpha and beta in a breast cancer cell line bearing an amplification of the gene encoding PI5P4K beta and deficient for p53 impaired growth on plastic and in xenografts. PMID: 24209622
    5. PIPkin IIbeta is expressed as a tagged protein, is active as revealed by immunoprecipitation and enzyme assay, and that cellular fractionation reveals that it is indeed nuclear. PMID: 17303380

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm.
  • 組織特異性:
    Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 8998

    OMIM: 603261

    KEGG: hsa:8396

    STRING: 9606.ENSP00000269554

    UniGene: Hs.260603



主站蜘蛛池模板: 无码成人片在线播放| 国产精品一区二区久久| 久久久久久综合网天天| 久久精品国产精油按摩| 国产薄丝脚交视频在线观看 | 国内熟女啪啪自拍| 国产精品亚洲二区在线看| a毛片终身免费观看网站| 国产三级精品三级在线观看| 中文字幕亚洲欧美日韩在线不卡 | 人人玩人人添人人澡| 亚洲中文综合网五月俺也去| 欧美黑人大战白嫩在线| 久久婷婷人人澡人人爽人人爱 | 国产97色在线 | 日| 久久精品国产清高在天天线| 午夜成人鲁丝片午夜精品| 日韩精品毛片无码一区到三区| 国产成人无码免费视频97| 亚洲精品国产av现线| 免费人成自慰网站| 精品久久久久久无码国产| 亚洲精品久久国产精品浴池| 久久九九有精品国产尤物| 亚洲精品夜夜夜| 欧洲性久久精品| 亚洲精品国产品国语原创| 成人网站www污污污网站| 国产又黄又大又粗的视频 | 久久婷婷五月综合色首页| 免费人成在线观看网站品爱网| 粉嫩av国产一区二区三区| 日本不卡高字幕在线2019| 亚洲精品国产嫩草在线观看东京热| 国产无遮挡免费真人视频在线观看 | 少妇熟女久久综合网色欲| 一区二区三区在线 | 日| 一本一道久久综合狠狠老| 国产极品粉嫩馒头一线天av| 波多野无码黑人在线播放| 国产精品无码v在线观看|