在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Peroxisomal multifunctional enzyme type 2 (HSD17B4)

  • 中文名稱:
    人HSD17B4重組蛋白
  • 貨號:
    CSB-EP010774HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人HSD17B4重組蛋白
  • 貨號:
    CSB-EP010774HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人HSD17B4重組蛋白
  • 貨號:
    CSB-BP010774HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人HSD17B4重組蛋白
  • 貨號:
    CSB-MP010774HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Name:HSD17B4 Synonyms:EDH17B4
  • Uniprot No.:
  • 別名:
    12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; 17 beta HSD 4; 17 beta HSD IV; 17 beta hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; 17beta estradiol dehydrogenase type IV; 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase; 3-alpha; 7-alpha; Beta hydroxyacyl dehydrogenase; Beta keto reductase; D 3 hydroxyacyl CoA dehydratase; D bifunctional protein; D bifunctional protein peroxisomal ; D-3-hydroxyacyl CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein; D-bifunctional protein; D-bifunctional protein, peroxisomal; DBP; DBP, peroxisomal; DHB4_HUMAN; EDH17B4; Enoyl-CoA hydratase 2; Hsd17b4; Hydroxysteroid (17-beta) Dehydrogenase 4; MFE 2; MFE-2; MPF-2; Multifunctional protein 2; Peroxisomal multifunctional enzyme type 2; Peroxisomal multifunctional protein 2; PRLTS1; SDR8C1; Short chain dehydrogenase/reductase family 8C member 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-736
  • 氨基酸序列
    MGSPLRFDGR VVLVTGAGAG LGRAYALAFA ERGALVVVND LGGDFKGVGK GSLAADKVVE EIRRRGGKAV ANYDSVEEGE KVVKTALDAF GRIDVVVNNA GILRDRSFAR ISDEDWDIIH RVHLRGSFQV TRAAWEHMKK QKYGRIIMTS SASGIYGNFG QANYSAAKLG LLGLANSLAI EGRKSNIHCN TIAPNAGSRM TQTVMPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG AGWIGKLRWE RTLGAIVRQK NHPMTPEAVK ANWKKICDFE NASKPQSIQE STGSIIEVLS KIDSEGGVSA NHTSRATSTA TSGFAGAIGQ KLPPFSYAYT ELEAIMYALG VGASIKDPKD LKFIYEGSSD FSCLPTFGVI IGQKSMMGGG LAEIPGLSIN FAKVLHGEQY LELYKPLPRA GKLKCEAVVA DVLDKGSGVV IIMDVYSYSE KELICHNQFS LFLVGSGGFG GKRTSDKVKV AVAIPNRPPD AVLTDTTSLN QAALYRLSGD WNPLHIDPNF ASLAGFDKPI LHGLCTFGFS ARRVLQQFAD NDVSRFKAIK ARFAKPVYPG QTLQTEMWKE GNRIHFQTKV QETGDIVISN AYVDLAPTSG TSAKTPSEGG KLQSTFVFEE IGRRLKDIGP EVVKKVNAVF EWHITKGGNI GAKWTIDLKS GSGKVYQGPA KGAADTTIIL SDEDFMEVVL GKLDPQKAFF SGRLKARGNI MLSQKLQMIL KDYAKL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity.
  • 基因功能參考文獻:
    1. This study reveals a crosstalk between acetylation and chaperone-mediated autophagy degradation in HSD17B4 regulation. PMID: 28296597
    2. we identified that methylation of the promoter CpG island of HSD17B4 was associated with the pathological complete response of HER2-positive breast cancer to trastuzumab and chemotherapy with a specificity of 79% PMID: 28186977
    3. Our findings supported that HSD17B4 was one of the genes contributing to Perrault syndrome in this consanguineous Chinese Han family. PMID: 28830375
    4. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2, CLPP and C10orf2 PMID: 26970254
    5. Results show that HSD17B4 is highly expressed in hepatocellular carcinoma (HCC) cells and activated NF-kappaB co-localized with the NF-kappaB-responsive element of HSD17B4 suggesting that HSD17B4 plays an important role in aggravated HCC progression. PMID: 25448063
    6. Structural MFE-2 instability is the molecular basis of D-bifunctional protein deficiency type III. PMID: 23308274
    7. Specific combination of compound heterozygous mutations in 17beta-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency. PMID: 23181892
    8. Molecular models of domain structure of MFE-2 from human, C. elegans, and Drosophila melanogaster lend support to possible structural role of MFE-2 domains including SCP-2L (sterol carrier protein 2-like) domain in human and C. elegans proteins. PMID: 23313254
    9. Epistasis between the HSD17B4 and thyroglobulin polymorphisms is associated with premature ovarian failure. A haplotype in the HSD17B4 gene was identified that was significantly associated with resistance to POF PMID: 22265031
    10. The diagnosis of a type III DBPD with a missense mutation (T15A) in the HSD17B4 gene, coding for D-bifunctional protein (DBP), could be established. PMID: 20949532
    11. MFE2 anchors its substrate around the region from Trp(249) to Arg(251) and positions the substrate along the hydrophobic cavity in the proper direction toward the catalytic center PMID: 20566640
    12. Perrault syndrome and DBP deficiency overlap clinically and Perrault syndrome is genetically heterogeneous. PMID: 20673864
    13. rs11205 in HSD17B4 was associated with testicular germ cell tumor. Risk doubled per copy of the minor A allele. Homozygosity of this allele quadrupled the risk vs. homozygous major G allele. The risk was increased both for seminoma & nonseminoma. PMID: 19776291
    14. crystal structure of 2-enoyl-CoA hydratase 2 PMID: 15644212
    15. Deficiency of this enzyme in man causes a severe developmental syndrome with abnormalities in several organs but in particular in the brain, leading to death within the first year of life. PMID: 16766224
    16. HSD17B4 is not only associated with the presence of prostate cancer, but is also a significant independent predictor of poor patient outcome. PMID: 19100308
    17. HSD17B4 mRNA is expressed in human skin, at similar levels in men and women. HSD17B4 levels are not altered by topical 17-beta-estradiol treatment. PMID: 18794456

    顯示更多

    收起更多

  • 相關疾病:
    D-bifunctional protein deficiency (DBPD); Perrault syndrome 1 (PRLTS1)
  • 亞細胞定位:
    Peroxisome.
  • 蛋白家族:
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性:
    Present in many tissues with highest concentrations in liver, heart, prostate and testis.
  • 數據庫鏈接:

    HGNC: 5213

    OMIM: 233400

    KEGG: hsa:3295

    STRING: 9606.ENSP00000420914

    UniGene: Hs.406861



主站蜘蛛池模板: 久久久久影院美女国产主播| 久久www香蕉免费人成| 国产精品午夜福利不卡| 日韩欧美精品有码在线| 精品无码国产污污污免费| 成年免费视频黄网站zxgk| 亚洲综合色在线视频www| 男女扒开双腿猛进入免费看污| 超薄肉色丝袜一区二区| 老熟妇高潮一区二区三区| 偷看农村妇女牲交| 国产在线清纯极品美女援交| 国产精品美女久久久久av爽| 欧美人与动牲交a欧美精品 | 无码国产偷倩在线播放| 大又大粗又爽又黄少妇毛片免费| 香蕉久久人人爽人人爽人人片av| 好男人www社区| 野外少妇被弄到喷水在线观看| 亚洲欧洲日产国码无码网站| 亚洲熟妇无码爱v在线观看| 无码一区二区三区av免费| 久久亚洲国产精品影院| 2021自拍偷在线精品自拍偷| 久久精品国产av一区二区三区| 久久久一本精品99久久精品66| 夜夜澡天天碰人人爱av| www成人国产高清内射| 女人裸体做爰免费视频| 男男女女爽爽爽免费视频| 国产精品卡一卡2卡三卡网站| 国产精品99无码一区二区| 国产69精品久久久久app下载| 亚洲欧美v国产蜜芽tv| 茄子视频国产在线观看| 亚洲精品成人无限看| 久久久av男人的天堂| 天堂中文在线8最新版地址| 五月开心播播网| 97久久国产露脸精品国产| 日本动漫瀑乳h动漫啪啪免费|