在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Pejvakin (PJVK)

Recombinant Human Pejvakin (PJVK)

  • 中文名稱：
    人PJVK重組蛋白
  • 貨號：
    CSB-YP607322HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PJVK重組蛋白
  • 貨號：
    CSB-EP607322HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PJVK重組蛋白
  • 貨號：
    CSB-EP607322HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PJVK重組蛋白
  • 貨號：
    CSB-BP607322HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PJVK重組蛋白
  • 貨號：
    CSB-MP607322HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PJVK
  • Uniprot No.：
  • 別名：
    Autosomal recessive deafness type 59 protein; DFNB59; DFNB59 deafness; autosomal recessive 59; Pejvakin; PJVK ; PJVK_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-352
  • 氨基酸序列
    MFAAATKSFV KQVGDGGRLV PVPSLSEADK YQPLSLVVKK KRCFLFPRYK FTSTPFTLKD ILLGDREISA GISSYQLLNY EDESDVSLYG RRGNHIVNDV GINVAGSDSI AVKASFGIVT KHEVEVSTLL KEITTRKINF DHSLIRQSRS SRKAVLCVVM ESIRTTRQCS LSVHAGIRGE AMRFHFMDEQ NPKGRDKAIV FPAHTTIAFS VFELFIYLDG AFDLCVTSVS KGGFEREETA TFALLYRLRN ILFERNRRVM DVISRSQLYL DDLFSDYYDK PLSMTDISLK EGTHIRVNLL NHNIPKGPCI LCGMGNFKRE TVYGCFQCSV DGQKYVRLHA VPCFDIWHKR MK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation.
  • 基因功能參考文獻：
    1. We identified in Moroccan deaf patients two mutations in PJVK and one mutation in MYO15A described for the first time in association with non-syndromic recessive hearing loss PMID: 28964305
    2. Study describes a genetic form of noise-induced hearing loss , by showing that pejvakin deficiency in mice and DFNB59 patients leads to hypervulnerability to sound, due to a peroxisomal deficiency. PMID: 26544938
    3. p.C312W fsX19 mutation causative of autosomal recessive, non-syndromic, prelingual sensorineural hearing impairment PMID: 25631766
    4. PCDH15 or DFNB59 variants are associated with poor CI performance, yet children with PCDH15 or DFNB59 variants might show clinical features indistinguishable from those of other typical pediatric cochlear implant recipients. PMID: 26166082
    5. a c.406C>T (p.R136X) nonsense mutation in the DFNB59 gene hearing loss in an isolated Arab population PMID: 21696384
    6. Missense mutation in PJVK causes progressive hearing loss. PMID: 22617256
    7. OTOF and PJVK gene variants have a role in auditory neuropathy spectrum disorder in Chinese patients PMID: 21935370
    8. failed to detect the presence either of mutations T54I and R183W in the exon 2 and exon 4 or any other deafness-associated mutations in the whole DFNB59 gene in this family PMID: 19160860
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    11. Observational study of genotype prevalence. (HuGE Navigator) PMID: 20739942
    12. DFNB59, a newly identified gene on chromosome 2q31.1-q31.3 mutated in four families segregating autosomal recessive auditory neuropathy PMID: 16804542
    13. We have identified a consanguineous family segregating autosomal recessive congenital progressive hearing loss (ARNSHL) and retinal degeneration with central vestibular dysfunction having homozygosity for a DFNB59 mutation. PMID: 17301963
    14. data indicate that nonsense mutations in DFNB59 cause nonsyndromic hearing loss, but that mutations in DFNB59 are not a major cause of nonsyndromic hearing impairment in the Turkish and Dutch population PMID: 17373699
    15. Mutations in DFNB59 are associated with autosomal recessive non-syndromic hearing loss in about 6.7% of GJB2-negative families. PMID: 17718865

    顯示更多

    收起更多

  • 相關疾病：
    Deafness, autosomal recessive, 59 (DFNB59)
  • 亞細胞定位：
    Peroxisome membrane. Cell projection, cilium.
  • 蛋白家族：
    Gasdermin family
  • 數據庫鏈接：

    HGNC: 29502

    OMIM: 610219

    KEGG: hsa:494513

    STRING: 9606.ENSP00000364271

    UniGene: Hs.87734



主站蜘蛛池模板： 久久久久久久久久久国产 | 丰满少妇在线观看网站| 51国产偷自视频区视频| 亚洲性色成人av| 夜夜澡人摸人人添人人看| 久久精品国产久精国产爱| 亚洲国产成人久久精品99| 久久97超碰色中文字幕总站| 无码精品a∨在线观看中文| 欧美亚洲色综久久精品国产| 日韩人妻无码一区二区三区99| 中年人妻丰满av无码久久不卡| 国产精品无打码在线播放| 天堂va欧美ⅴa亚洲va| 欧美精品一区二区精品久久| 精品国产成人av在线| 亚欧美日韩香蕉在线播放视频| 国产精品一区二区久久乐下载| 成年黄页网站大全免费无码| 国产手机在线无码播放视频| www插插插无码免费视频网站| 国产精品久久久久久吹潮 | 国产人妻久久精品二区三区| 国产精品成人99久久久久| 欧美男男大粗吊1069| 级r片内射在线视频播放| 一二三四视频社区在线| 日本欧美一区二区免费视频| 国产精品成人午夜久久| 色婷婷亚洲一区二区三区| 无码一区二区三区| 宅男66lu国产在线观看| 天堂网www天堂资源网| 又嫩又硬又黄又爽的视频| 久久久久无码国产精品一区| 国产成人av免费观看 | 久青青在线观看视频国产| 青青草原亚洲| 日韩成av人片在线观看| 又色又爽又黄的吃奶视频免费观看| 中国国产1级毛卡片|