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  4. Recombinant Human PMS1 protein homolog 1 (PMS1), partial

Recombinant Human PMS1 protein homolog 1 (PMS1), partial

  • 中文名稱：
    人PMS1重組蛋白
  • 貨號：
    CSB-YP018245HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PMS1重組蛋白
  • 貨號：
    CSB-EP018245HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PMS1重組蛋白
  • 貨號：
    CSB-EP018245HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PMS1重組蛋白
  • 貨號：
    CSB-BP018245HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PMS1重組蛋白
  • 貨號：
    CSB-MP018245HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PMS1
  • Uniprot No.：
  • 別名：
    DNA mismatch repair protein PMS1; FLJ98259; HNPCC3; hPMS1; Human homolog of yeast mutL; Mismatch repair gene PMSL1; pms1; PMS1 postmeiotic segregation increased 1 (S. cerevisiae); PMS1 postmeiotic segregation increased 1; PMS1 protein homolog 1; PMS1_HUMAN; PMSL1; Rhabdomyosarcoma antigen MU RMS 40.10B; Rhabdomyosarcoma antigen MU RMS 40.10E
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probably involved in the repair of mismatches in DNA.
  • 基因功能參考文獻：
    1. Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population. PMID: 25162662
    2. These studies establish that the Mlh1-Pms1 endonuclease is required for MMR in a previously uncharacterized Exo1-independent MMR pathway. PMID: 24204293
    3. PMS1 is most likely deregulated by post-transcriptional modification in oral squamous cell carcinoma. PMID: 23608172
    4. hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA PMID: 11809883
    5. The expression of hMLH1 and hPMS1 was significantly low in some large B-cell lymphomas and in mantle cell lymphomas of the blastoid type and may be related to the natural history of these neoplasms. PMID: 11999575
    6. Data show that DNA damage induces the accumulation of hPMS1, hPMS2, and hMLH1 through ataxia-telangiectasia-mutated (ATM)-mediated protein stabilization. PMID: 15226443
    7. hPMS1 may be useful as CD4+ helper T cell antigens for immunotherapy of pancreatic cancer patients. PMID: 15856462
    8. In pstreplicative mismatch repair, this protein interacts wiwth MutL protein. PMID: 17148452

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    DNA mismatch repair MutL/HexB family
  • 數據庫鏈接：

    HGNC: 9121

    OMIM: 600258

    KEGG: hsa:5378

    STRING: 9606.ENSP00000406490

    UniGene: Hs.111749



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