在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human P2X purinoceptor 2 (P2RX2), partial

Recombinant Human P2X purinoceptor 2 (P2RX2), partial

  • 中文名稱：
    人P2RX2重組蛋白
  • 貨號：
    CSB-YP880063HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人P2RX2重組蛋白
  • 貨號：
    CSB-EP880063HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人P2RX2重組蛋白
  • 貨號：
    CSB-EP880063HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人P2RX2重組蛋白
  • 貨號：
    CSB-BP880063HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人P2RX2重組蛋白
  • 貨號：
    CSB-MP880063HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ATP receptor; MGC129601; P2RX 2; P2RX2; P2RX2_HUMAN; P2X purinoceptor 2; P2X Receptor subunit 2; P2X2; P2X2a; Purinergic receptor; Purinergic receptor P2X ligand gated ion channel 2; Purinergic receptor P2X2 isoform A; Purinergic receptor P2X2 isoform B; Purinergic receptor P2X2 isoform C; Purinergic receptor P2X2 isoform D; Purinergic receptor P2X2 isoform H; Purinergic receptor P2X2 isoform I
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.
  • 基因功能參考文獻：
    1. identified P2RX2, KCNQ5, ERBB3 and SOCS3 to be associated with the progression of age-related hearing impairment PMID: 29325454
    2. These findings indicate that the CaMKII-mediated GluA1 phosphorylation of S567 and S831 is critical for P2X2-mediated AMPAR internalization and ATP-driven synaptic depression. PMID: 27624155
    3. Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor hP2X2/3 channel. PMID: 27129281
    4. Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 and P2X3 subunits PMID: 26184350
    5. The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2, P2X3 and P2X7 receptors in the different histological layers of the human urinary bladder. PMID: 26253104
    6. A novel mutation in the P2RX2 gene was identified in a MELAS family. PMID: 25788561
    7. The locus designated DFNA41 maps to a 15 cM region on chromosome 12q24.32-qter, proximal to the marker D12S1609. PMID: 12161595
    8. Molecular analyses of P2RX2 identified a novel missense mutation. PMID: 24211385
    9. Data indicate that the P2X2(I328C) receptor was activated by propyl-methanethiosulfonate (MTS) as effectively as by ATP. PMID: 24273165
    10. Data indicate that MgATP2- activates P2X1 and P2X3, but not P2X2 and P2X4 receptors. PMID: 23959888
    11. the contribution of the extracellular, transmembrane, and intracellular segments to recovery from desensitization PMID: 23740251
    12. analysis of dominantly inherited, progressive sensorineural hearing loss DFNA41 in a six-generation kindred revealed a rare heterozygous allele, P2RX2 c.178G > T (p.V60L), at chr12:133,196,029, which cosegregated with fully penetrant hearing loss PMID: 23345450
    13. trimeric P2X receptors containing only two intact binding sites can be readily activated by ATP. PMID: 22828800
    14. High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism PMID: 22556417
    15. one subunit of P2X2 and two subunits of P2X3 form P2X2/3 heteromeric receptors, whereas two subunits of P2X2 and one subunit of P2X6 constitute P2X2/6 receptors PMID: 22378790
    16. Studies indicate that P2X1, P2X2, and P2X4 receptors are detected in preglomerular microvessels. PMID: 21768526
    17. analysis of agonists trapped in ATP-binding sites of the P2X2 receptor PMID: 21576497
    18. GABA(A) receptor dynamics are regulated by interaction with purinergic P2X(2) receptors PMID: 21343285
    19. Data suggest that interactions between alpha3beta4 nAChRs and P2X2 receptors may modulate transmission at enteric synapses that use ATP and acetylcholine as co-transmitters. PMID: 20426799
    20. Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP PMID: 20699225
    21. Whole-cell voltage clamp recordings functionally correlated immunolocalisation of ATP-gated ion channels in isolated hair cells and supporting cells. P2X immunoreactivity was widespread throughout the epithelial lining of the cochlea. PMID: 12395104
    22. Data provide biochemical evidence that in addition to the rapidly desensitising P2X1 and P2X3 receptors, the slowly desensitising subtypes P2X2, P2X4, and P2X5 are trimers of identical subunits. PMID: 15313628
    23. Effect of acute hypoxia on cloned homo- and heteromeric P2X2 receptors expressed in human embryonic kidney 293 cells. PMID: 15331767
    24. P2X(2) receptors are trimers, whereas the P2X(6) receptor subunits do not form stable oligomers PMID: 15657042
    25. support a common site of ATP action at P2X receptors and suggest that non-conserved residues also play a regulatory role in agonist action PMID: 18487206
    26. VILIP1 constitutively binds to P2X2 receptors and displays enhanced interactions in an activation- and calcium-dependent manner owing to exposure of its binding segment in P2X2 receptors PMID: 18922787
    27. Specimens (12/15) from patients with spinal cord lesions and specimens (8/11) demonstrated strong staining for P(2)X(2) receptors in the detrusor muscle and the urothelium. PMID: 19104511
    28. Intracellular cysteine430 residue mediates the potentiation of P2X2 receptor activity by reactive oxygen species. PMID: 19793987

    顯示更多

    收起更多

  • 相關疾病：
    Deafness, autosomal dominant, 41 (DFNA41)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membranes of hair cells in the organ of Corti.
  • 蛋白家族：
    P2X receptor family
  • 數據庫鏈接：

    HGNC: 15459

    OMIM: 600844

    KEGG: hsa:22953

    UniGene: Hs.258580



主站蜘蛛池模板： 天堂网在线最新版www资源网| av无码人妻波多野结衣| 天堂网www最新版官网| 久久精品99久久香蕉国产| 撕开奶罩揉吮奶头视频| 国产农村熟妇videos| 中文在线а√天堂官网| 午夜免费国产体验区免费的| 无码少妇一区二区三区免费| 玩弄人妻少妇老师美妇厨房 | 夜夜高潮天天爽欧美| a片免费视频在线观看| 成人亚洲精品久久久久| 亚拍精品一区二区三区探花| 久久天天躁狠狠躁夜夜躁app| 激情欧美成人久久综合| 国产98色在线 | 国产| 中文字幕人妻伦伦| 亚洲色成人四虎在线观看| 国产精品久久久久久不卡盗摄 | 成年无码动漫av片在线尤物| 日日日日做夜夜夜夜做无码| 亚洲熟妇av一区| 国产suv精品一区二区| 97超级碰碰人妻中文字幕 | 国产精品99久久99久久久动漫| 亚洲经典三级| 亚洲精品久久中文字幕| 久9视频这里只有精品试看| 熟妇人妻中文字幕无码老熟妇| 亚洲人成亚洲精品| 中文字幕奈奈美被公侵犯| 男女啪啪网站大全免费| 激情综合色综合啪啪五月丁香| 国产三区在线成人av| 久久国内精品自在自线观看| 熟妇五十路六十路息与子| 玩弄中年熟妇正在播放| 亚洲欧洲无卡二区视頻| 亚洲熟妇无码八v在线播放| 亚洲爆乳少妇无码激情|