Recombinant Human Oligoribonuclease, mitochondrial (REXO2 SFN SMFN CGI-114)

中文名稱：
貨號：

CSB-YP446358HU
規格：
來源：

Yeast
其他：

中文名稱：
貨號：

CSB-EP446358HU
規格：
來源：

E.coli
其他：

中文名稱：
貨號：

CSB-EP446358HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：
貨號：

CSB-BP446358HU
規格：
來源：

Baculovirus
其他：

中文名稱：
貨號：

CSB-MP446358HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ORN
Uniprot No.：

Q9Y3B8
別名：

Oligoribonuclease, mitochondrial; EC 3.1.15.-; RNA exonuclease 2 homolog; Small fragment nuclease; REXO2 SFN SMFN CGI-114
種屬：

Homo sapiens (Human)
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development.; 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides.
基因功能參考文獻：
1. results demonstrate that 14-3-3sigma induces cisplatin resistance in esophageal squamous cell carcinoma cells PMID: 26346170
2. CBY1 downregulation in CML arises from reduced protein stability upon binding to 14-3-3sigma adapter protein. The ubiquitin proteasome system UPS participates in reducing stability of CBY1 bound with 14-3-3sigma through enhanced SUMOylation. PMID: 26147002
3. Loss of 14-3-3sigma sensitizes cells to UVB. After a transient cell cycle arrest, 14-3-3sigma-deficient cells die by undergoing mitotic catastrophe. PMID: 24102700
4. REXO2 is an oligoribonuclease active in human mitochondria and present both in cytosolic and mitochondrial fractions. PMID: 23741365
5. SFN expression is involved in resistance of RSa cells to UV-C-induced cell death through the roles it plays in the DNA repair process PMID: 15362935
6. The expression in E. coli of orn and homologues from Mycobacterium smegmatis and human, and large-scale purification of the three enzymes, is reported. PMID: 18023590
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亞細胞定位：

Mitochondrion intermembrane space. Mitochondrion matrix. Mitochondrion. Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.
蛋白家族：

Oligoribonuclease family
組織特異性：

Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus.
數據庫鏈接：

HGNC: 17851

OMIM: 607149

KEGG: hsa:25996

STRING: 9606.ENSP00000265881

UniGene: Hs.677190