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  4. Recombinant Human OTU domain-containing protein 7B (OTUD7B), partial

Recombinant Human OTU domain-containing protein 7B (OTUD7B), partial

  • 中文名稱：
    人OTUD7B重組蛋白
  • 貨號：
    CSB-YP753588HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人OTUD7B重組蛋白
  • 貨號：
    CSB-EP753588HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人OTUD7B重組蛋白
  • 貨號：
    CSB-EP753588HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人OTUD7B重組蛋白
  • 貨號：
    CSB-BP753588HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人OTUD7B重組蛋白
  • 貨號：
    CSB-MP753588HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    OTUD7B
  • Uniprot No.：
  • 別名：
    Cellular zinc finger anti NF kappa B protein ; Cellular zinc finger anti-NF-kappa-B protein; CEZANNE; HGNC:16683; OTU domain containing protein 7B; OTU domain-containing protein 7B; OTU7B_HUMAN; OTUD7B; ZA20D1; Zinc finger A20 domain containing protein 1; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin.
  • 基因功能參考文獻：
    1. Study demonstrated that the N-terminal UBA domain is crucial for the function of Cezanne during NF-kappaB activation. Cezanne is recognized and recruited into activated TNFR complex by specifically binding to polyubiquitinated signaling proteins after TNF stimulation through its N-terminal polyubiquitin binding site. PMID: 28817177
    2. Cezanne may be a novel antioncogene that has a pivotal role in the invasion of hepatocellular carcinoma and contribute to the selection of patients who may benefit from adjuvant transcatheter arterial chemoembolization to prevent recurrence. PMID: 28880268
    3. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling PMID: 28489822
    4. Findings indicated both cezanne-1 and IGF1R expressions were negative independent predictive factors for the prognosis of lung adenocarcinoma, respectively. There was a close positive interrelationship between cezanne-1 and IGF1R expression. PMID: 28365890
    5. expression of OTUD7B and NIK were negatively correlated in non-small cell lung cancer tumor samples. The higher expression of OTUD7B was associated with smaller tumor size, less lymph node metastasis and earlier TNM stage. the high expression of OTUD7B was associated with good prognosis of NSCLC patients, and a high OTUD7B/low NIK index can predict even better prognosis. also, OTUD7B is an independent markers of survival. PMID: 27499151
    6. crystal structures of Cezanne alone and in complex with monoubiquitin and Lys11-linked diubiquitin, in combination with hydrogen-deuterium exchange mass spectrometry, enable a reconstruction of the enzymatic cycle in great detail PMID: 27732584
    7. these data reveal a novel mechanism for the regulation of the expression of HIF2a, demonstrating that the HIF2a promoter is regulated by E2F1 directly and that Cezanne regulates HIF2a expression through control of E2F1 levels PMID: 26148512
    8. Taken together, these results suggest that hepatitis C virus NS5A protein interacts with OTUD7B, thereby modulating its deubiquitinase activity. PMID: 26112491
    9. Cezanne has a pivotal role in tumor progression and prognosis, and may act as a potential prognostic biomarker for survival in hepatocellular carcinoma patients. PMID: 25638165
    10. data suggest that Cezanne is essential for HIF-1alpha protein stability and that loss of Cezanne stimulates HIF-1alpha degradation via proteasome-independent routes, possibly through chaperone-mediated autophagy. PMID: 25355043
    11. Genome wide association study shows evidence of association between mammographic density and SNPs in high linkage disequilibrium with rs11205277, rs11205303 in gene MTMR11 and rs67807996 in gene OTUD7B. PMID: 25353672
    12. Inflammatory responses to ischemia are controlled by a balance between TRAF6 ubiquitination and deubiquitination, and Cezanne is a key regulator of this process. PMID: 23564640
    13. identified a deubiquitinating enzyme, Cezanne-1, that opposes receptor degradation and enhances EGFR signaling PMID: 22179831
    14. There is an excessive inflammatory response but insufficient up-regulation of A20 expression in inflammatory bowel disease patients. PMID: 21624200
    15. DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. PMID: 21097510
    16. Cezanne is identified as the first deubiquitinase with Lys11-linkage preference. PMID: 20622874
    17. cleaves ubiquitin from proteins PMID: 12682062
    18. Cezanne forms a novel negative feedback loop in pro-inflammatory signaling and that it suppresses NF-kappaB activation by targeting RIP1 signaling intermediaries for deubiquitination PMID: 18178551
    19. H(2)O(2) prolongs NF-kappaB activation in co-stimulated cells by suppressing the negative regulatory functions of Cezanne and IkappaBalpha. PMID: 18474597

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase C64 family
  • 組織特異性：
    Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells.
  • 數據庫鏈接：

    HGNC: 16683

    OMIM: 611748

    KEGG: hsa:56957

    STRING: 9606.ENSP00000358131

    UniGene: Hs.98322



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