在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 (MACROD1)

Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 (MACROD1)

  • 中文名稱：
    人MACROD1重組蛋白
  • 貨號：
    CSB-YP860244HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MACROD1重組蛋白
  • 貨號：
    CSB-EP860244HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MACROD1重組蛋白
  • 貨號：
    CSB-MP860244HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MACROD1
  • Uniprot No.：
  • 別名：
    MACROD1; LRP16; ADP-ribose glycohydrolase MACROD1; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; EC 3.1.1.106; Protein LRP16; [Protein ADP-ribosylaspartate] hydrolase MACROD1; EC 3.2.2.-; [Protein ADP-ribosylglutamate] hydrolase MACROD1; EC 3.2.2.-
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-325
  • 氨基酸序列
    MSLQSRLSGR LAQLRAAGQL LVPPRPRPGH LAGATRTRSS TCGPPAFLGV FGRRARTSAG VGAWGAAAVG RTAGVRTWAP LAMAAKVDLS TSTDWKEAKS FLKGLSDKQR EEHYFCKDFV RLKKIPTWKE MAKGVAVKVE EPRYKKDKQL NEKISLLRSD ITKLEVDAIV NAANSSLLGG GGVDGCIHRA AGPLLTDECR TLQSCKTGKA KITGGYRLPA KYVIHTVGPI AYGEPSASQA AELRSCYLSS LDLLLEHRLR SVAFPCISTG VFGYPCEAAA EIVLATLREW LEQHKDKVDR LIICVFLEKD EDIYRSRLPH YFPVA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
  • 基因功能參考文獻：
    1. Here, the authors report that LRP16 selectively interacts and activates double-stranded RNA-dependent kinase (PKR), and also acts as scaffolds to assist the formation of a ternary complex of PKR and IKKbeta, prolonging the polymers of ADP-ribose (PAR)-dependent nuclear factor kappa B (NF-kappaB) transactivation caused by DNA-damaging agents and confers acquired chemoresistance. PMID: 28820388
    2. The results indicate that abnormal LRP16 expression is noted in neuroendocrine lung tumors and the expression can give insight into the pathogenesis of the disease. PMID: 26261536
    3. LRP16, through its constitutive interactions with PARP1 and IKKgamma, functions to facilitate the lesion-specific recruitment of PARP1 and IKKgamma and, ultimately, the concomitant recruitment of PIASy to IKKgamma in response to DNA damage. PMID: 25735744
    4. LRP16 gene overexpression shows a promotive effect on proliferation of K562 cells. PMID: 19840441
    5. LRP16 may play an important role in leukemia progression by promoting cell proliferation, regulating cell cycle, and antagonizing radiation-induced DNA damage. PMID: 19958623
    6. Findings not only indicate that LRP16 is a crucial regulator for NF-kappaB activation inside the nucleus, but also suggest that LRP16 may be an important contributor to the aberrant activation of NF-kappaB in tumors. PMID: 21483817
    7. lrp16 is a leukemic oncogene and closely relates to genesis and progression of leukemia. PMID: 19698216
    8. LRP16 expression is related to the degree of differentiation, invasiveness, metastasis and prognosis of colorectal carcinoma. PMID: 20355243
    9. K18 attenuates estrogen receptor alpha-mediated signaling by sequestering LRP16 in cytoplasm. PMID: 20035625
    10. LRP16 may have a role in invasion, metastasis and prognosis of gastric cancer PMID: 19824120
    11. ERalpha and Sp1 play a role in activation of the promoter PMID: 15691879
    12. LRP16 overexpression is closely correlated to the positive rates of estrogen receptor and progesterone receptor, Ki-67 level, tumor diameter, and axillary lymph node metastasis of breast cancer. PMID: 16831279
    13. identified a novel RUNX1 fusion partner, LRP16 on 11q13 involving t(11;21)(q13;q22) PMID: 17532767
    14. A role for estrogenically regulated LRP16 as an ERalpha coactivator, providing a positive feedback regulatory loop for ERalpha signal transduction. PMID: 17914104
    15. the single macro domain in LRP16 can serve as the androgen receptor coactivator PMID: 19022849
    16. The unliganded ERalpha upregulated LRP16 expression and enhanced LRP16 promoter activity in SKOV3 cells; however, this induction was blocked by estrogen stimulation. PMID: 19403568

    顯示更多

    收起更多

  • 相關疾病：
    A chromosomal aberration involving MACROD1 is found in acute leukemia. Translocation t(11;21)(q13;q22) that forms a RUNX1-MACROD1 fusion protein.
  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    HGNC: 29598

    OMIM: 610400

    KEGG: hsa:28992

    STRING: 9606.ENSP00000255681

    UniGene: Hs.602898



主站蜘蛛池模板： 精品无码专区久久久水蜜桃| 少妇把腿扒开让我爽爽视频| 无码人妻丰满熟妇啪啪| 国产高清av在线播放| 女人张开双腿让男人猛桶| 亚洲乱码av中文一区二区软件| 在线播放午夜理论片| 久久人人爽人人爽人人片av高清 | 人妻少妇精品中文字幕av蜜桃| 中文字幕av无码不卡| 蜜臀av综合网| 精品无码乱码av| 国产精品线路一线路二| 国产精品99久久久久久人| 一区二区乱子伦在线播放| 亚洲欧洲av无码专区| 中文字幕无码专区人妻系列| 夜夜躁狠狠躁日日躁2022| 真人无码作爱免费视频| 性按摩xxxx在线观看| 国产成人卡2卡3卡4乱码| 国产av麻豆天堂亚洲国产av刚刚碰| 宝宝好涨水快流出来免费视频| 久久精品国产99国产精品亚洲| 国内精品视频自在一区| 国产av国片精品一区二区| 国产在线视频一区二区三区 | 无码国产精品一区二区免费式芒果 | 日韩人妻一区二区三区免费 | 偷偷要色偷偷中文无码| a欧美爰片久久毛片a片| 久久午夜神器| 国产嫖妓一区二区三区无码| 曰韩欧美群交p片内射| 亚洲成a∧人片在线播放无码 | 色综合天天视频在线观看| 欧洲黑大粗无码免费| 男人猛躁进女人免费播放| 日韩少妇内射免费播放18禁裸乳| 九月婷婷人人澡人人添人人爽| 免费两性的视频网站|