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  4. Recombinant Human Nischarin (NISCH), partial

Recombinant Human Nischarin (NISCH), partial

  • 中文名稱：
    人NISCH重組蛋白
  • 貨號：
    CSB-YP015821HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NISCH重組蛋白
  • 貨號：
    CSB-EP015821HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NISCH重組蛋白
  • 貨號：
    CSB-EP015821HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NISCH重組蛋白
  • 貨號：
    CSB-BP015821HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NISCH重組蛋白
  • 貨號：
    CSB-MP015821HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NISCH
  • Uniprot No.：
  • 別名：
    NISCH; IRAS; KIAA0975; Nischarin; Imidazoline receptor 1; I-1; IR1; Imidazoline receptor antisera-selected protein; hIRAS; Imidazoline-1 receptor; I1R; Imidazoline-1 receptor candidate protein; I-1 receptor candidate protein; I1R candidate protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
  • 基因功能參考文獻：
    1. These experiments demonstrate an important role of Nischarin in regulating cell attachment, which adds to our understanding of the early events of the metastatic process in breast cancer. PMID: 29415725
    2. In the prefrontal cortex of long-term opiate/cocaine abusers, IRAS content was increased when compared to matched controls. PMID: 28461172
    3. IRAS is a new mu opioid receptor interacting protein that regulates agonist-induced trafficking of mu opioid receptor. PMID: 26363797
    4. The present data confirmed that Nishcharin might be a novel tumor suppressor and plays an important role in breast cancer cell apoptosis and metastasis, which can be used as a potential therapeutic target for breast cancer treatment. PMID: 28131840
    5. Data found that NISCH was significantly downregulated in ovarian neoplasm through its promotor silencing with hypermethylation and its expression was correlated with poor prognosis. PMID: 25724667
    6. Nischarin expression may therefore be used as a marker to predict the invasiveness and metastasis of primary breast cancer PMID: 25695373
    7. Tobacco smoke induces methylation changes in the NISCH gene promoter before any detectable cancer. PMID: 23503203
    8. unctional interaction between LKB1 and Nischarin to inhibit cell migration and breast tumor progression PMID: 23572524
    9. Imidazoline receptor 1 gene plays a role in the development of cardiac hypertrophy and ventirular remodeling. PMID: 22483786
    10. Nischarin reduces alpha5 integrin expression leading to reduction of FAK phosphorylation and Rac GTP loading, which in turn reduces tumor growth. NISCH also regulates PAK and LIMK signaling. PMID: 21917605
    11. Insulin receptor substrate 4 associates with the protein IRAS (IRAS protein) PMID: 11912194
    12. The heart possesses imidazoline I1-receptors that are up-regulated in the presence of hypertension or heart failure, which suggests their involvement in cardiovascular regulation. PMID: 12021582
    13. I(1)-receptors can abrogate the primary signaling cascade activated by NGF, most likely by increasing levels of a specific phosphatase to return dually phosphorylated ERK to its unphosphorylated state. PMID: 12865160
    14. hIRAS expression in PC12 cells resulted in protection against apoptosis PMID: 12868002
    15. Results suggest that IRAS may represent a previously unknown anti-apoptotic protein involved in the regulation of cell survival. PMID: 15028619
    16. Results describe three alternatively spliced transcripts of the human I(1)-imidazoline receptor candidate gene, IRAS. PMID: 15028621
    17. Results suggest that imidazoline-1 receptors (I(1)R) and alpha(2)-noradrenergic receptors (alpha(2)AR) may interact with each other. PMID: 15028622
    18. platelets lacked the 170-kD form of IRAS, but 33-kD and 85-kD bands were detectable and seemed to be possible fragments of full-length IRAS PMID: 15028623
    19. PX domain of imidazoline receptor antisera-selected protein(IRAS) is essential for association with phosphatidylinositol 3-phosphate-enriched endosomal membranes but is insufficient without coiled-coil domain PMID: 15475348
    20. The signaling pathway of IRAS in response to I1R agonists coupled with the activation of PC-PLC and its downstream signal transduction molecule, ERK. These findings are similar to those in the signaling pathways of native I1R. PMID: 16598778
    21. shows strong affinity to clonidine and regulates blood pressure. PMID: 18561481

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  • 亞細胞定位：
    Cell membrane. Cytoplasm. Early endosome. Recycling endosome.
  • 組織特異性：
    Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrine tissues.
  • 數據庫鏈接：

    HGNC: 18006

    OMIM: 615507

    KEGG: hsa:11188

    STRING: 9606.ENSP00000339958

    UniGene: Hs.435290



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