在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Nicotinate phosphoribosyltransferase (NAPRT), partial

  • 中文名稱:
    人NAPRT重組蛋白
  • 貨號:
    CSB-BP015451HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NAPRT重組蛋白
  • 貨號:
    CSB-EP015451HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NAPRT重組蛋白
  • 貨號:
    CSB-MP015451HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    NAPRT
  • Uniprot No.:
  • 別名:
    FHA HIT interacting protein; FHA-HIT-interacting protein; FHIP; NAPRT1; NAPRTase; Nicotinate phosphoribosyltransferase; Nicotinate phosphoribosyltransferase domain containing 1; Nicotinate phosphoribosyltransferase domain-containing protein 1; Nicotinic acid phosphoribosyltransferase; PNCB_HUMAN; PP3856
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 表達區域:
    229-538aa
  • 氨基酸序列
    MLAPAAGEGPGVDLAAKAQVWLEQVCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSLCAGQSP
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
  • 基因功能參考文獻:
    1. No correlation between IDH1/2 mutation status and sensitivity for NAMPT inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma PMID: 28860121
    2. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases PMID: 28416276
    3. High NAPRTase expression is associated with neoplasms. PMID: 26675378
    4. Tumor-specific promoter hypermethylation of NAPRT1 inactivates one of two NAD salvage pathways, resulting in synthetic lethality with the coadministration of a NAMPT inhibitor. PMID: 24097869
    5. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner PMID: 22570471
    6. NAPRT expression was varied in lymphomas with 30-50% low expression except for Hodgkin's lymphoma where 85% displayed low expression PMID: 21492230
    7. NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD PMID: 17604275

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    NAPRTase family
  • 數據庫鏈接:

    HGNC: 30450

    OMIM: 611552

    KEGG: hsa:93100

    STRING: 9606.ENSP00000401508

    UniGene: Hs.493164



主站蜘蛛池模板: 国产成人久久a免费观看| 天天爽夜夜爽人人爽| 老司机午夜福利av无码特黄a| 人妻一本久道久久综合久久鬼色| 99精品无人区乱码在线观看| 西西人体444www大胆无码视频| 人妻无码中文字幕一区二区三区| 免费人成网站在线观看视频| 男男又爽又黄又无遮挡网站| 无码av一区二区三区无码| 欧美私人情侣网站| 国内精品综合久久久40p| 影视av久久久噜噜噜噜噜三级| 午夜成人鲁丝片午夜精品| 国内精品久久久人妻中文字幕| 亚洲日韩欧洲无码av夜夜摸| 日韩av高潮喷水在线观看| 一道本在线伊人蕉无码| 国产乱子伦视频一区二区三区| 日韩精品无码中文字幕一区二区| 亚洲精品无码不卡av| 亚洲欧美在线观看| 亚洲精品第一国产综合亚av| 热99re久久精品天堂| 久久久橹橹橹久久久久| 亚洲国产精品自产在线播放| 99国产精品久久久久久久成人| 凸偷窥中国女人洗澡| 日本xxxxx片免费观看喷水| 色国产精品一区在线观看| 婷婷五月综合激情中文字幕| 无线日本视频精品| 国语自产精品视频在线第100页| 午夜精品一区二区三区免费视频| 精品无码av无码专区| 老汉老妇姓交视频| 国产成人青青久久大片| 国产精品v欧美精品∨日韩| 国产无套护士在线观看| 先锋影音av最新资源| 水蜜桃色314在线观看|