在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Neuroserpin (SERPINI1)

Recombinant Human Neuroserpin (SERPINI1)

  • 中文名稱：
    人SERPINI1重組蛋白
  • 貨號：
    CSB-YP859934HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SERPINI1重組蛋白
  • 貨號：
    CSB-EP859934HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SERPINI1重組蛋白
  • 貨號：
    CSB-EP859934HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SERPINI1重組蛋白
  • 貨號：
    CSB-BP859934HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SERPINI1重組蛋白
  • 貨號：
    CSB-MP859934HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SERPINI1
  • Uniprot No.：
  • 別名：
    DKFZp781N13156; Neuroserpin; NEUS_HUMAN; Peptidase inhibitor 12; PI-12; PI12; Protease inhibitor 12 ; Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1; Serine or cysteine proteinase inhibitor clade I member 1; Serpin I1; Serpin peptidase inhibitor clade I (neuroserpin) member 1; SERPINI1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    17-410
  • 氨基酸序列
    TGAT FPEEAIADLS VNMYNRLRAT GEDENILFSP LSIALAMGMM ELGAQGSTQK EIRHSMGYDS LKNGEEFSFL KEFSNMVTAK ESQYVMKIAN SLFVQNGFHV NEEFLQMMKK YFNAAVNHVD FSQNVAVANY INKWVENNTN NLVKDLVSPR DFDAATYLAL INAVYFKGNW KSQFRPENTR TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE ISMMLVLSRQ EVPLATLEPL VKAQLVEEWA NSVKKQKVEV YLPRFTVEQE IDLKDVLKAL GITEIFIKDA NLTGLSDNKE IFLSKAIHKS FLEVNEEGSE AAAVSGMIAI SRMAVLYPQV IVDHPFFFLI RNRRTGTILF MGRVMHPETM NTSGHDFEEL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
  • 基因功能參考文獻：
    1. We present two pediatric cases of progressive myoclonic epilepsy with SERPINI1 pathogenic variants that lead to a severe presentation. PMID: 28631894
    2. Data indicated that rs9853967 and rs11714980 polymorphisms in CCM3 and SERPINI1respectively could be associated with a protective role in cerebral cavernous malformations disease. PMID: 27737651
    3. SERPINI1 is an important regulator of epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer PMID: 26892864
    4. The thermal and chemical stability along with the polymerisation propensity of both Wild Type and Glu289Ala NS were characterized. PMID: 26329378
    5. This C-terminal lability is not required for neuroserpin polymerisation in the endoplasmic reticulum, but the additional glycan facilitates degradation of the mutant protein during proteasomal impairment. PMID: 26367528
    6. the protective effect of neuroserpin maybe independent from its canonical interaction with a tissue-type plasminogen activator PMID: 26176694
    7. Neuroserpin is expressed in naive effector memory and central memory CD4 and CD8 T cell subsets, and monocytes, B cells, and NK cells. T-cell activation caused its translocation to the immunologic synapse, secretion, and delayed downregulation. PMID: 25670787
    8. Molecular Dynamics simulations suggest that Neuroserpin conformational stability and flexibility arise from a spatial distribution of intramolecular salt-bridges and hydrogen bonds. PMID: 25450507
    9. Alzheimer's disease brain tissues with elevated neuroserpin protein also showed increased expression of THRbeta1 and HuD PMID: 24036060
    10. our study did not provide any evidence for an association between genetic variation at the SERPINI1 locus and ischemic stroke PMID: 21487809
    11. the origins of conformational lability PMID: 21961602
    12. Neuroprotective properties of neuroserpin may be related to the inhibition of excitotoxicity, inflammation, as well as blood brain barrier disruption that occur after acute ischemic stroke. PMID: 21569344
    13. Hrd1 and gp78 mediate mutant neuroserpin turnover through the ERAD pathway. PMID: 21507957
    14. high serum neuroserpin levels before intravenous tPA and neuroserpin levels decrease at 24 h after ischaemic stroke, independently of tPA treatment, may have a role in good functional outcome PMID: 21174006
    15. The latent and polymer hNS forms obtained at 45 degrees C and 85 degrees C differ in their chemical and thermal stabilities; furthermore, the human neuroserpin polymers also differ in size and morphology PMID: 21081089
    16. investigated the refolding and polymerization pathways of wild-type neuroserpin and of the pathogenic mutants S49P and H338R PMID: 20691191
    17. Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro PMID: 11880376
    18. The interactions between NSP and t-PA were distinct from those between plasmin and NSP, suggesting that the physiologic effect of t-PA-NSP interactions may be more complex than previously thought. PMID: 12228252
    19. Neuroserpin has a role as a selective inhibitor of tissue-type plasminogen activator in the central nervous system [review] PMID: 14983220
    20. neuroserpin mutants that cause dementia accumulate as polymers within the endoplasmic reticulum PMID: 15090543
    21. tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system PMID: 15269833
    22. reactive centre loop of neuroserpin Portland being partially inserted into beta-sheet A to adopt a conformation similar to an intermediate on the polymerization pathway PMID: 15291813
    23. Data show that the S49P mutant of neuroserpin that causes the dementia familial encephalopathy with neuroserpin inclusion bodies (FENIB) forms a latent species in vitro and in vivo in addition to the formation of polymers. PMID: 15664988
    24. neuroserpin interacts with Abeta(1-42) to form off-pathway non-toxic oligomers and so protects neurons in Alzheimer disease PMID: 16849336
    25. intergenic region of the head-to-head PDCD10-SERPINI1 gene pair provides an interesting and informative example of a complex regulatory system PMID: 17212813
    26. in a French family with the S52R mutation of the neuroserpin gene, progressive myoclonic epilepsy was associated with a frontal syndrome PMID: 17606885
    27. This study provides the first evidence that neuroserpin is associated with early-onset ischemic stroke among Caucasian women. PMID: 17961231
    28. conformational modification in the protein under oxidative stress PMID: 18051703
    29. We report a neuroserpin mutation that causes electrical status epilepticus of slow-wave sleep. PMID: 18591508
    30. Neuroserpin and tissue plasminogen activator are associated with amyloid-beta plaques in Alzheimer brain tissue. PMID: 19222708
    31. Human neuroserpin: structure and time-dependent inhibition PMID: 19265707
    32. Analyses restricted to glioblastoma (n = 254) yielded significant associations for the SELP, DEFB126/127, SERPINI1, and LY96 genetic regions. PMID: 19423540
    33. intracellular neuroserpin polymers activate NF-kappaB by a pathway that is independent of the IRE1, ATF6, and PERK limbs of the canonical unfolded protein response but is dependent on intracellular calcium PMID: 19423713

    顯示更多

    收起更多

  • 相關疾病：
    Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB)
  • 亞細胞定位：
    Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Perikaryon.
  • 蛋白家族：
    Serpin family
  • 組織特異性：
    Detected in brain cortex and hippocampus pyramidal neurons (at protein level). Predominantly expressed in the brain.
  • 數據庫鏈接：

    HGNC: 8943

    OMIM: 602445

    KEGG: hsa:5274

    STRING: 9606.ENSP00000295777

    UniGene: Hs.478153



主站蜘蛛池模板： 日本亲子乱子伦xxxx50路| 色欲精品国产一区二区三区av| 国产在线精品无码不卡手机免费| 欧美黑人又粗又大xxx| 露脸内射熟女--69xx| 亚洲成av人的天堂在线观看| 国产麻豆成人传媒免费观看| 精品国产乱码久久久久软件| 欧美激情精品成人一区| 婷婷综合久久狠狠色99h| 天堂а√8在线最新版在线| 人妻丰满熟妞av无码区| 国产偷人妻精品一区二区在线| av天堂中av世界中文在线播放| 婷婷五月综合色中文字幕| 窝窝午夜理论片影院| 无遮挡aaaaa大片免费看 | 亚洲精品456在线播放| 国产精品被窝福利一区| 在线精品国精品国产尤物| 清纯小美女主播流白浆| 中文字幕人成乱码熟女| 色天天天综合色天天| 4hu四虎永久在线影院| 内射老阿姨1区2区3区4区| 无码人妻久久一区二区三区蜜桃| 又湿又黄裸乳漫画无遮挡网站| 久久无码喷吹高潮播放不卡| 妺妺窝人体色www在线观看| 国产自产v一区二区三区c| 国产gv在线观看受被做哭| 18禁止观看强奷免费国产大片| 午夜精品久久久久久久99老熟妇| 久久国产36精品色熟妇| 人人爽人人爽人人片av免费| 日韩中文字幕在线专区| 国产女主播喷水视频在线观看| 成年午夜精品久久久精品| 亚洲伦无码中文字幕另类| 国产激情艳情在线看视频| 亚洲aⅴ无码国精品中文字慕|