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  4. Recombinant Human Neuron-specific vesicular protein calcyon (CALY), partial

Recombinant Human Neuron-specific vesicular protein calcyon (CALY), partial

  • 中文名稱：
    Recombinant Human Neuron-specific vesicular protein calcyon(CALY),partial
  • 貨號：
    CSB-YP868364HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Neuron-specific vesicular protein calcyon(CALY),partial
  • 貨號：
    CSB-EP868364HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Neuron-specific vesicular protein calcyon(CALY),partial
  • 貨號：
    CSB-EP868364HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Neuron-specific vesicular protein calcyon(CALY),partial
  • 貨號：
    CSB-BP868364HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Neuron-specific vesicular protein calcyon(CALY),partial
  • 貨號：
    CSB-MP868364HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CALY
  • Uniprot No.：
  • 別名：
    CALCYON; Caly; CALY_HUMAN; D1 dopamine receptor interacting protein; Drd1ip; Neuron specific vesicular protein calcyon; Neuron-specific vesicular protein calcyon; NSG3; RP11-122K13.5
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.
  • 基因功能參考文獻：
    1. Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization PMID: 22843680
    2. Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation. PMID: 21415033
    3. CaMKII is a key effector in the Ca2+ and microtubule-dependent delivery of calcyon to the cell surface. PMID: 14534309
    4. Genetic variants in the CALCYON gene do not play a major role in predisposition to either schizophrenia or cocaine dependence i PMID: 14755439
    5. Quantitative trait analyses of most common haplotype, designated C1, showed significant relationships with both the inattentive and hyperactive/impulsive dimensions of the disorder. PMID: 16172615
    6. Using the calcyon cytosolic domain as bait, we isolated clathrin light chain in a yeast two-hybrid screen. The interaction domain was mapped to the heavy chain binding domain and C-terminal regions of light chain. PMID: 16595675
    7. mobility and storage properties of calcyon-containing vesicles imply that they play a role in brain plasticity PMID: 17885599

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  • 亞細胞定位：
    Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
  • 蛋白家族：
    NSG family
  • 組織特異性：
    Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.
  • 數據庫鏈接：

    HGNC: 17938

    OMIM: 604647

    KEGG: hsa:50632

    STRING: 9606.ENSP00000252939

    UniGene: Hs.148680



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