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  4. Recombinant Human Neurocan core protein (NCAN), partial

Recombinant Human Neurocan core protein (NCAN), partial

  • 中文名稱：
    人NCAN重組蛋白
  • 貨號：
    CSB-YP015513HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NCAN重組蛋白
  • 貨號：
    CSB-EP015513HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NCAN重組蛋白
  • 貨號：
    CSB-EP015513HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NCAN重組蛋白
  • 貨號：
    CSB-BP015513HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NCAN重組蛋白
  • 貨號：
    CSB-MP015513HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NCAN
  • Uniprot No.：
  • 別名：
    Chondroitin sulfate proteoglycan 3; Cspg3; Ncan; NCAN_HUMAN; NEUR; Neurocan core protein; Neurocan proteoglycan
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
  • 基因功能參考文獻：
    1. NCAN rs2228603 is not a risk factor for the incidence of NAFLD in Chinese population. The dual and opposite role of T variant in protecting liver with a higher level of HDL was found. PMID: 27887608
    2. This study aims to analyze the influences of single-nucleotide polymorphism in the NCAN-CILP2 region on non-alcoholic fatty liver disease and plasma lipid levels in the Asian and Pacific ethnic groups. PMID: 26758378
    3. NCAN genotype is associated with limbic gray matter alterations in healthy and subjects with major depression in brain areas implicated in emotion perception and regulation PMID: 25801500
    4. current data demonstrate that common genetic variation in NCAN influences both neural processing and cognitive performance in healthy subjects. PMID: 25220293
    5. The frequency of the NCAN rs2228603 T allele was significantly increased in patients with HCC due to ALD (15.1%) compared to alcoholic cirrhosis without HCC (9.3%), alcoholic controls (7.2%), healthy controls (7.9%), and HCV associated HCC (9.1%). PMID: 24946282
    6. NCAN risk variant is associated with cortical folding and thickness in bipolar disorder and schizophrenia. PMID: 23795679
    7. Conditional analysis shows that a neighbouring gene, TM6SF2, not NCAN, is responsible for the Chr 19 GWAS locus previously associated with fibrosing non-alcoholic fatty liver disease (NAFLD). PMID: 24978903
    8. NCAN rs2228603[T] is a risk factor for liver inflammation and fibrosis, suggesting that this locus is responsible for progression from steatosis to steatohepatitis. PMID: 23594525
    9. no genetic association between risk allele A for NCAN locus rs1064395 and schizophrenia. PMID: 23198940
    10. In the combined patient sample, the NCAN risk allele was significantly associated with the "mania" factor, in particular the subdimension "overactivity. PMID: 22952076
    11. The rs1064395 A-allele was significantly over-represented in schizophrenia patients compared to controls. Our data suggest that genetic variation in NCAN is a common risk factor for bipolar disorder and schizophrenia. PMID: 22497794
    12. High neurocan is associated with the invasive phenotype of low-grade astrocytoma. PMID: 21997179
    13. Sex (male)-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels is observed both the Mulao and Han ethnic groups. PMID: 22208664
    14. Genetic variation in the neurocan gene (NCAN) showed genome-wide significant association with bipolar disorder. PMID: 21353194

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Aggrecan/versican proteoglycan family
  • 組織特異性：
    Brain.
  • 數據庫鏈接：

    HGNC: 2465

    OMIM: 600826

    KEGG: hsa:1463

    STRING: 9606.ENSP00000252575

    UniGene: Hs.169047



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