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  4. Recombinant Human Neuroblast differentiation-associated protein AHNAK (AHNAK), partial

Recombinant Human Neuroblast differentiation-associated protein AHNAK (AHNAK), partial

  • 中文名稱：
    Recombinant Human Neuroblast differentiation-associated protein AHNAK(AHNAK) ,partial
  • 貨號：
    CSB-YP600257HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Neuroblast differentiation-associated protein AHNAK(AHNAK) ,partial
  • 貨號：
    CSB-EP600257HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Neuroblast differentiation-associated protein AHNAK(AHNAK) ,partial
  • 貨號：
    CSB-EP600257HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Neuroblast differentiation-associated protein AHNAK(AHNAK) ,partial
  • 貨號：
    CSB-BP600257HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Neuroblast differentiation-associated protein AHNAK(AHNAK) ,partial
  • 貨號：
    CSB-MP600257HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    AHNAK
  • Uniprot No.：
  • 別名：
    AHNAK; AHNAK nucleoprotein (desmoyokin); AHNAK nucleoprotein; AHNAKRS; AHNK_HUMAN; Desmoyokin; Fragments; MGC5395; Neuroblast differentiation associated protein AHNAK; Neuroblast differentiation-associated protein AHNAK; PM227
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May be required for neuronal cell differentiation.
  • 基因功能參考文獻：
    1. These findings confirm that AHNAK functions in the chemotherapeutic response of breast cancer cells while also emphasizing the need for further investigation into potential implications for AHNAK in terms of predicting and modulating treatment response. PMID: 29309757
    2. our results suggest that AHNAK acts as a tumor suppressor that negatively regulates TNBC cell proliferation, TNBC xenograft growth and metastasis via different signaling pathways. PMID: 28494797
    3. AHNAK enables mammary carcinoma cells to produce and release extracellular vesicles that cause disruption of the stroma by surrounding fibroblasts PMID: 27374178
    4. Based on the findings, the authors designate the Chlamydia trachomatis gene product corresponding to ct694-ctl0063translocated membrane-associated effector A (TmeA). Overall, the data reveal a role of TmeA during chlamydial invasion that manifests independently of effects on AHNAK. PMID: 28970272
    5. Examination of Gene Expression Omnibus database data sets suggests that downregulation of AHNAK mRNA and mutation of the AHNAK gene are common in metastatic melanoma and correlates to a poor outcome. PMID: 26672724
    6. inhibition of Ahnak can promote generation of induced pluripotent stem cells (iPSC) via up-regulation of endogenous c-Myc. PMID: 26598518
    7. tetrandrine may inhibit the growth of Hep-2 cells by decreasing the intracellular concentration of Ca2+ and upregulating the expressions of Brg1 and AHNAK PMID: 26642721
    8. Authors show here that AnxA2, p11 and AHNAK are required for type 3 secretion system-mediated Salmonella invasion of cultured epithelial cells. PMID: 23931152
    9. High AHNAK expression is asociated with mesothelioma. PMID: 24253341
    10. novel strategies for an accurate prognosis in larynx carcinoma and suggest potential mechanisms of inflammation-mediated tumor progression PMID: 23409183
    11. While the structure-based consensus sequence allows interactions with various stretches of the AHNAK C-terminal domain, comparison with other S100 structures reveals that the sequence has been optimized for binding to S100A10. PMID: 23275167
    12. The AHNAK peptide adopts a coil conformation that arches across the heterotetramer contacting both annexin A2 and S100A10 protomers with tight affinity. PMID: 22940583
    13. these results define ahnak1 in muscle connective tissue as a novel feature of two genetically distinct muscular dystrophies that might contribute to disease pathology. PMID: 22057634
    14. AHNAK constitutes a novel mechanism in post-transcriptional control of gene expression. PMID: 21940993
    15. Multiple titin antibodies, particularly those recognizing the PEVK region, cross-react with AHNAK. PMID: 11746675
    16. he carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton PMID: 12153988
    17. The carboxyl-terminal ahnak domain exerts a stabilizing effect on muscle contractility via its interaction with actin of thin filaments. PMID: 15001564
    18. AHNAK mediates activation of phospholipase C-gamma1 through protein kinase C PMID: 15033986
    19. Ahnak has a critical role in cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation PMID: 16319140
    20. A study demonstrating that Annexin2 is required for strong binding of S100A10 to the C-terminal domain of the protein Ahnak. PMID: 16984913
    21. AHNAK accumulates when calpain 3 is defective in skeletal muscle of calpainopathy patients; moreover, AHNAK fragments cleaved by CAPN3 have lost their affinity for dysferlin. PMID: 18334579

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  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    HGNC: 347

    OMIM: 103390

    KEGG: hsa:79026

    STRING: 9606.ENSP00000367263

    UniGene: Hs.502756



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