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  4. Recombinant Human Nesprin-2 (SYNE2), partial

Recombinant Human Nesprin-2 (SYNE2), partial

  • 中文名稱：
    人SYNE2重組蛋白
  • 貨號：
    CSB-YP841001HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SYNE2重組蛋白
  • 貨號：
    CSB-EP841001HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SYNE2重組蛋白
  • 貨號：
    CSB-EP841001HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SYNE2重組蛋白
  • 貨號：
    CSB-BP841001HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SYNE2重組蛋白
  • 貨號：
    CSB-MP841001HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SYNE2
  • Uniprot No.：
  • 別名：
    DKFZP434H2235; DKFZp686E01115; DKFZp686H1931; FLJ11014; FLJ43727; FLJ45710; FLJ46790; KIAA1011; Nesprin-2; Nesprin2; NUA; NUANCE; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element; Nucleus and actin connecting element protein; Protein NUANCE; Spectrin repeat containing nuclear envelope 2; Synaptic nuclear envelope protein 2; Synaptic nuclei expressed gene 2; SYNE 2; Syne-2; SYNE2; SYNE2_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis.
  • 基因功能參考文獻：
    1. variants of EGFR and SYNE2 play an important role in p21 regulation and are associated with the clinical outcome of HBV-related hepatocellular carcinoma in a TP53-indenpdent manner PMID: 27502069
    2. The authors identified the nuclear envelope protein nesprin-2 as a binding partner for fascin in a range of cell types in vitro and in vivo. Nesprin-2 interacts with fascin through a direct, F-actin-independent interaction, and this binding is distinct and separable from a role for fascin within filopodia at the cell periphery. PMID: 27554857
    3. these data identify N-terminal nesprin-2 variants as novel regulators of beta-catenin signaling. PMID: 27321956
    4. We show that AMPH-1/BIN1 binds to nesprin and actin, as well as to the microtubule-binding protein CLIP170 in both species. We propose that BIN1 has a direct and evolutionarily conserved role in nuclear positioning, altered in myopathies. PMID: 26506308
    5. The significance of these shorter isoforms of nesprin, were evaluated. PMID: 24718612
    6. nesprin-1 and nesprin-2 both regulate nuclear and cytoplasmic architecture. PMID: 24931616
    7. nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development. PMID: 25516977
    8. Each mutation in LMNA has a distinct impact on the Nersprin-2 interaction that substantially explains how distinct mutations in widely expressed genes lead to the formation of phenotypically different diseases. PMID: 23977161
    9. High Nesprin-2 expression is associated with colorectal cancer. PMID: 24080406
    10. Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds. PMID: 22768332
    11. Study presents crystal structures of the human SUN2-KASH1/2 complex, i.e. SUN2 complexed with the C-terminal 29 residues of human Nesprin-1 or -2 (the core of the LINC complex). PMID: 22632968
    12. novel isoform, nesprin-2-epsilon, was found to be the major mRNA and protein product of the nesprin-2 gene. PMID: 21820406
    13. Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development PMID: 20108321
    14. Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope. PMID: 20801886
    15. Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation. PMID: 19861416
    16. Nesprin-2 binds lamin and emerin at the nuclear envelope in skeletal muscle. PMID: 15671068
    17. Nesprin-2 has a scaffolding function at the nuclear membrane PMID: 15843432
    18. The Nesprin-2 the conserved C-terminal amino acids PPPX is essential for the interaction with a C-terminal region in Sun1. PMID: 16079285
    19. The characterisation of the residues both in emerin and in nesprin-1alpha and -2beta which are involved in their interaction is reported. PMID: 17462627
    20. Screening for DNA variations in the genes encoding nesprin-1 (SYNE1) and nesprin-2 (SYNE2) in 190 probands with Emery Dreifuss muscular dystrophy identified four heterozygous missense mutations. PMID: 17761684
    21. propose nesprin-2 giant as a structural reinforcer at the nuclear envelope in LMNA S143F progeria cells PMID: 17881656
    22. Nesprin-2 is an important scaffold protein implicated in the maintenance of nuclear envelope architecture. PMID: 18477613
    23. association with human nesprin-3 appeared to be stronger for torsinADeltaE than for torsinA. TorsinA also associated with the KASH domains of nesprin-1 and -2 PMID: 18827015

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  • 相關疾病：
    Emery-Dreifuss muscular dystrophy 5, autosomal dominant (EDMD5)
  • 亞細胞定位：
    Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton. Mitochondrion. Nucleus, nucleoplasm. Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    Nesprin family
  • 組織特異性：
    Widely expressed, with higher level in kidney, adult and fetal liver, stomach and placenta. Weakly expressed in skeletal muscle and brain. Isoform 5 is highly expressed in pancreas, skeletal muscle and heart.
  • 數據庫鏈接：

    HGNC: 17084

    OMIM: 608442

    KEGG: hsa:23224

    STRING: 9606.ENSP00000350719

    UniGene: Hs.745014



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