在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Necdin (NDN)

Recombinant Human Necdin (NDN)

  • 中文名稱：
    人NDN重組蛋白
  • 貨號：
    CSB-YP859515HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NDN重組蛋白
  • 貨號：
    CSB-EP859515HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NDN重組蛋白
  • 貨號：
    CSB-EP859515HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NDN重組蛋白
  • 貨號：
    CSB-BP859515HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NDN重組蛋白
  • 貨號：
    CSB-MP859515HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NDN
  • Uniprot No.：
  • 別名：
    HsT16328; NDN; NECD_HUMAN; Necdin; Necdin homolog; Necdin MAGE family member; necdin related protein; PWCR
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-321
  • 氨基酸序列
    MSEQSKDLSD PNFAAEAPNS EVHSSPGVSE GVPPSATLAE PQSPPLGPTA APQAAPPPQA PNDEGDPKAL QQAAEEGRAH QAPSAAQPGP APPAPAQLVQ KAHELMWYVL VKDQKKMIIW FPDMVKDVIG SYKKWCRSIL RRTSLILARV FGLHLRLTSL HTMEFALVKA LEPEELDRVA LSNRMPMTGL LLMILSLIYV KGRGARESAV WNVLRILGLR PWKKHSTFGD VRKLITEEFV QMNYLKYQRV PYVEPPEYEF FWGSRASREI TKMQIMEFLA RVFKKDPQAW PSRYREALEE ARALREANPT AHYPRSSVSE D
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences.
  • 基因功能參考文獻：
    1. the single-nucleotide polymorphism rs850807, which is putatively functional and linked with MAGEL2 and NDN Genetic variation in rs850807 was strongly and exclusively associated with the ideas of reference subscale of the schizophrenia spectrum, which is best typified as paranoia PMID: 29343559
    2. this study shows that hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer PMID: 28521288
    3. One candidate variant was located in an alpha helix of Necdin (NDN), phased to the paternally inherited allele. NDN is maternally imprinted within the 15q11.2 Prader-Willi Syndrome (PWS) region PMID: 28213671
    4. NDN is an imprinted tumor suppressor gene which affects cancer cell motility, invasion and growth and that its loss of function in ovarian cancer can be caused by both genetic and epigenetic mechanisms. PMID: 26689988
    5. Germline single nucleotide polymorphism in necdin gene is associated with breast cancer. PMID: 26384308
    6. NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas PMID: 26518708
    7. Necdin expression declined during replicative aging of IMR90 primary human fibroblasts or after induction of premature senescence.Showed that in normal human cells, Necdin expression mimicked the effect of p53 inactivation by increasing radioresistance. PMID: 22691188
    8. Hypermethylation and mutation of necdin is associated with neoplasms. PMID: 23549060
    9. necdin exerts its pro-survival activity by counteracting the action of the pro-apoptotic protein Cell Cycle Apoptosis Regulatory Protein (CCAR1/CARP1) PMID: 22905258
    10. necdin has multiple roles within protein complexes in different subcellular compartments, and indicate that it can utilize multiple karyopherin-dependent pathways to modulate its localization. PMID: 22442722
    11. In pre-adipocytes, necdin over-expression inhibits adipogenesis, while reducing necdin levels enhances adipogenic differentiation in tissue culture cell PMID: 22305984
    12. Necdin, a negative growth regulator,identified as a novel STAT3 target gene, whose expression is down-regulated at the mRNA and protein levels when STAT3 is constitutively active. PMID: 22046235
    13. Necdin is implicated through the TNF-receptor 1 pathway in the developmental death of motoneuron PMID: 21912643
    14. rare variant of necdin (p.V318A) was described in a family with Kallmann syndrome Familial segregation and in vitro analysis suggested that this non-synonymous variant did not have a direct causative role in hypogonadism phenotype. PMID: 21543378
    15. Data suggest that the effects of necdin deletion on the developing nervous system may depend on the relative expression of p75NTR and TrkA in the cells of particular regions of the nervous system. PMID: 21150695
    16. Necdin is a key protein regulating polarization of the cytoskeleton and myosin activation during development. PMID: 20665884
    17. The necdin gene is imprinted, with preferential expression from the paternal allele in human and mouse. PMID: 9302265
    18. the constitutively up-regulated expression of pre-IL-1 alpha in the nuclei of systemic sclerosis (SSc) fibroblasts up-regulates proliferation and matrix production of SSC fibroblasts through binding necdin PMID: 12913118
    19. Tissue-specific gene expression regulation and imprinted epigenetic modifications of the human NDN gene. PMID: 15247330
    20. Necdin can be a novel negative regulator of HIF-1alpha stability via the direct interaction. PMID: 15978586
    21. Lack of Necdin expression induces perinatal serotonergic alterations that affect the maturation and function of the respiratory network, inducing breathing deficits in mice and probably in Prader-Willi patients. PMID: 18272695
    22. Data suggest that Nogo-A is a novel necdin binding protein and inhibits necdin-accelerated neuronal neurite outgrowth by sequestering necdin in the cytoplasm. PMID: 19386232
    23. regulates neuronal development. (review) PMID: 19517793
    24. Confirmation of NDN as a tumor suppressor may have implications for monitoring of PWS patients and could present a novel cancer therapeutic target PMID: 19626646

    顯示更多

    收起更多

  • 亞細胞定位：
    Perikaryon. Nucleus. Note=Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.
  • 組織特異性：
    Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leuko
  • 數據庫鏈接：

    HGNC: 7675

    OMIM: 176270

    KEGG: hsa:4692

    STRING: 9606.ENSP00000332643

    UniGene: Hs.50130



主站蜘蛛池模板： 无码人妻久久久一区二区三区| 高清无码午夜福利视频| 国产成人精品男人的天堂| 男人扒开女人双腿猛进视频| 玖玖玖国产精品视频| 真实国产乱子伦视频| 无码中文字幕波多野结衣| 蜜臀少妇人妻在线| 永久免费看啪啪网址入口| 久久人妻av中文字幕| 人与禽交videos欧美| 狠狠色噜噜狠狠狠狠色综合久| 国产无夜激无码av毛片| 色播在线精品一区二区三区四区| 国产精品亚洲第一区在线观看| 日本成本人片免费网站| 午夜久久久久久禁播电影| 麻豆国产精品va在线观看| 日本天天黄网站| 国产亚洲曝欧美曝妖精品| 18黄暴禁片在线观看| 亚洲精品97久久中文字幕无码| 国产精品爽爽久久久久久竹菊| 国产美女爽到喷出水来视频| 亚洲欧美中文字幕日韩一区二区| 少妇大叫好爽受不了午夜视频 | 亚洲中文字幕无码永久在线不卡| 亚洲成色www久久网站| 自慰系列无码专区| 国产高清在线精品一区小说| 亚洲.欧美.在线视频| 伴郎粗大的内捧猛烈进出视频观看 | 色综合中文综合网| 免费又黄又裸乳的视频| 在线看片免费人成视频在线影院 | 人人爽久久涩噜噜噜av| 日本高清不卡aⅴ免费网站| 国产香蕉尹人在线观看视频| 特大巨黑吊xxxx高潮| 正在播放的国产a一片| 亚洲大片av毛片免费|