在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human NF-kappa-B-repressing factor (NKRF)

Recombinant Human NF-kappa-B-repressing factor (NKRF)

  • 中文名稱：
    人NKRF重組蛋白
  • 貨號：
    CSB-YP015836HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NKRF重組蛋白
  • 貨號：
    CSB-EP015836HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NKRF重組蛋白
  • 貨號：
    CSB-BP015836HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NKRF重組蛋白
  • 貨號：
    CSB-MP015836HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NKRF
  • Uniprot No.：
  • 別名：
    NKRF; ITBA4; NRF; NF-kappa-B-repressing factor; NFkB-repressing factor; Protein ITBA4; Transcription factor NRF
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-690
  • 氨基酸序列
    MEKILQMAEG IDIGEMPSYD LVLSKPSKGQ KRHLSTCDGQ NPPKKQAGSK FHARPRFEPV HFVASSSKDE RQEDPYGPQT KEVNEQTHFA SMPRDIYQDY TQDSFSIQDG NSQYCDSSGF ILTKDQPVTA NMYFDSGNPA PSTTSQQANS QSTPEPSPSQ TFPESVVAEK QYFIEKLTAT IWKNLSNPEM TSGSDKINYT YMLTRCIQAC KTNPEYIYAP LKEIPPADIP KNKKLLTDGY ACEVRCQNIY LTTGYAGSKN GSRDRATELA VKLLQKRIEV RVVRRKFKHT FGEDLVVCQI GMSSYEFPPA LKPPEDLVVL GKDASGQPIF NASAKHWTNF VITENANDAI GILNNSASFN KMSIEYKYEM MPNRTWRCRV FLQDHCLAEG YGTKKTSKHA AADEALKILQ KTQPTYPSVK SSQCHTGSSP RGSGKKKDIK DLVVYENSSN PVCTLNDTAQ FNRMTVEYVY ERMTGLRWKC KVILESEVIA EAVGVKKTVK YEAAGEAVKT LKKTQPTVIN NLKKGAVEDV ISRNEIQGRS AEEAYKQQIK EDNIGNQLLR KMGWTGGGLG KSGEGIREPI SVKEQHKREG LGLDVERVNK IAKRDIEQII RNYARSESHT DLTFSRELTN DERKQIHQIA QKYGLKSKSH GVGHDRYLVV GRKRRKEDLL DQLKQEGQVG HYELVMPQAN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.
  • 基因功能參考文獻：
    1. NKRF is a nucleolar HSP essential for nucleolus homeostasis and cell survival under proteotoxic stress. NKRF is a thermosensor translocating from the nucleolus to the nucleoplasm during heat stress; nucleolar pools are replenished upon HSF1-mediated NKRF resynthesis. NKRF is an unconventional HSP crucial for correct rRNA processing. Under stress conditions, NKRF directs XRN2 nucleolus/nucleoplasm trafficking. PMID: 28096332
    2. Data suggest that L protein from LCMV interactions with host proteome, specifically DDX3X, NKRF, and TRIM21. (LCMV = Lymphocytic choriomeningitis mammarenavirus; DDX3X = DEAD-box helicase 3; NKRF = NF-kappa-B-repressing factor; TRIM21 = tripartite motif-containing protein-21) PMID: 29261807
    3. depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step. PMID: 28115624
    4. NF-kappaB-repressing factor (NKRF) phosphorylation modulates promoter-proximal transcription elongation of NF-kappaB/NKRF-regulated genes via direct interactions with elongation complex in response to specific stimuli PMID: 26340924
    5. The up-regulated NKRF serves as an endogenous repressor for IP-10 and IL-8 synthesis to hinder host from robust response to MTb infection. PMID: 25135111
    6. MIR29 targets and reduces expression of CLDN1 and NKRF to increase intestinal permeability in inflammatory bowel disease. PMID: 25277410
    7. NRF may serve as an endogenous repressor to prevent robust increase in IP-10/CXCL10 and IL-8/CXCL8 when TB bacterial load is high. PMID: 24223729
    8. The expression of NKRF is decreased in PBMCs of patients with stable COPD. The downregulation of NKRF was found to be closely related to enhanced IL-8 production from these peripheral blood cells through de-repression of the IL-8 promoter. PMID: 22441735
    9. The results indicate that JKTBP1 regulates the level of NRF protein expression by binding to both NRF 5' and 3' UTRs. PMID: 21300069
    10. role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene PMID: 12381793
    11. cDNA is 3247 bp long, contains three exons and maps to human chromosome Xq24. NRF is widely expressed in human tissues. PMID: 14744032
    12. Full-length NRF is highly enriched in nucleoli and only a small fraction of NRF is found in the nucleoplasm and cytoplasm PMID: 15226370
    13. NRF interrupts the regulatory coupling of LTR binding factors and transcription elongation events; this inhibitory mechanism might contribute to transcriptional quiescence of integrated HIV-1 provirus PMID: 16107696
    14. Induction of MMP-9 gene expression is regulated by oscillatory/cumulative activation of NFkappaB in a colon cancer cell line. PMID: 17186550
    15. The data of this study show that JKTBP1 and the 14-nt element act independently to mediate NRF internal ribosome entry segment activity. PMID: 17592041
    16. saimiri transformation-associated protein of subgroup C induces NF-kappaB activation PMID: 18560378
    17. Induction of NRF in human airway smooth muscle cells by neutrophil elastase mediates the suppression of interleukin (IL)-8/CXCL8 expression. PMID: 19542452

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleolus.
  • 組織特異性：
    Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.
  • 數據庫鏈接：

    HGNC: 19374

    OMIM: 300440

    KEGG: hsa:55922

    STRING: 9606.ENSP00000442308

    UniGene: Hs.437084



主站蜘蛛池模板： 香蕉av福利精品导航| 亚洲成a人片在线观看无码| 国产午夜精品一区理论片飘花| 日韩精品中文字幕无码一区 | 少妇高潮太爽了在线视| 少妇与子乱在线观看| 最新国产成人无码久久| 乱码国产丰满人妻www| 色欲色香天天天综合网www | 国产69久久精品成人看| 亚洲中文字幕无码中文| 九九九精品成人免费视频小说| 欧美性猛交xxxx免费看蜜桃| 99精品无码一区二区| 久久久www成人免费看片| 亚洲欧美日韩成人一区在线| 久久久久久久综合狠狠综合| 国产情侣久久久久aⅴ免费| 国产二级一片内射视频播放| 国产最新精品自产在线观看| 又色又爽又黄的视频日本| 特黄大片又粗又大又暴| 亚洲精品无码久久千人斩| 中国china体内裑精亚洲日本| 熟妇高潮一区二区三区| 欧美成人看片黄a免费看| 欧美丰腴丰满大屁股熟妇| 国产成人av乱码免费观看| 亚洲精品乱码久久久久久自慰| 97碰碰碰人妻无码视频| 在线不卡日本v一区二区| 欧洲丰满少妇a毛片| 国产最大成人亚洲精品| 久久www免费人成一看片| 爱性久久久久久久久| 精品国产一二三产品区别在哪| 亚洲精品无码ma在线观看| 国产乱来乱子视频| 日产日韩亚洲欧美综合下载| 国产欧美另类久久久精品不卡| 久久综合九色综合欧美98|