在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human NEDD4 family-interacting protein 2 (NDFIP2), partial

  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-YP885735HU1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-EP885735HU1
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-EP885735HU1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-BP885735HU1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-MP885735HU1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    NDFIP2; KIAA1165; N4WBP5A; NEDD4 family-interacting protein 2; NEDD4 WW domain-binding protein 5A; Putative MAPK-activating protein PM04/PM05/PM06/PM07; Putative NF-kappa-B-activating protein 413
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation. May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination.
  • 基因功能參考文獻:
    1. Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi. PMID: 26363003
    2. PTEN/Akt and MAP kinase signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 and Ndfip2 PMID: 20534535
    3. role in regulating epithelial sodium channel PMID: 12050153
    4. N4WBP5A may play a regulatory role in modulating Nedd4 activity at the level of the Golgi apparatus in T lymphocytes PMID: 12796489
    5. N4WBP5A acts as an adaptor to recruit Nedd4 family ubiquitin-protein ligases to the protein trafficking machinery PMID: 15252135
    6. Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them. PMID: 19343052

    顯示更多

    收起更多

  • 亞細胞定位:
    Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane.
  • 組織特異性:
    Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18537

    OMIM: 610041

    KEGG: hsa:54602

    STRING: 9606.ENSP00000218652

    UniGene: Hs.525093



主站蜘蛛池模板: 嘿咻嘿咻男女免费专区| 亚洲欧洲无码av电影在线观看| 久久精品人人槡人妻人人玩av| 99热成人精品热久久| 亚洲精品成人区在线观看| 久久综合色鬼综合色| 日本中文字幕乱码aa高清电影| 国产精品自在在线午夜免费| 日韩人妻无码精品久久久不卡| 性一交一无一伦一精一品| 欧美 日产 国产在线观看| 亚洲欲色欲香天天综合网| 国产熟妇久久777777| yyyy11111少妇无码影院| 亚洲色欲色欲天天天www| 18女下面流水不遮图| 在线播放五十路熟妇| 冲田杏梨av一区二区三区| 欧美亚洲日本日韩在线| 精产一二三产区m553| 又粗又大又硬毛片免费看| 久久久久国产精品人妻aⅴ四季| 怡红院成永久免费人视频新的| 女女互磨互喷水高潮les呻吟 | 日本猛少妇色xxxxx猛叫| 国产动作大片中文字幕| 成人性三级欧美在线观看| 亚洲人成日韩中文字幕无卡| 性欧美暴力猛交69hd| 精品国产乱码久久久久久夜深人妻| 人妻无码系列一区二区三区| 藏春阁福利视频| 亚洲国精产品一二二线| 亚洲日本在线在线看片| 亚洲肥老太bbw中国熟女| 午夜射精日本三级| 久久老子午夜精品无码怎么打| 中文无码av在线亚洲电影| 97久久精品无码一区二区天美| 免费看又黄又爽又猛的视频软件| 欧美日韩一本的免费高清视频 |