在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human NEDD4 family-interacting protein 2 (NDFIP2), partial

  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-YP885735HU1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-EP885735HU1
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-EP885735HU1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-BP885735HU1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-MP885735HU1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    NDFIP2; KIAA1165; N4WBP5A; NEDD4 family-interacting protein 2; NEDD4 WW domain-binding protein 5A; Putative MAPK-activating protein PM04/PM05/PM06/PM07; Putative NF-kappa-B-activating protein 413
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation. May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination.
  • 基因功能參考文獻:
    1. Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi. PMID: 26363003
    2. PTEN/Akt and MAP kinase signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 and Ndfip2 PMID: 20534535
    3. role in regulating epithelial sodium channel PMID: 12050153
    4. N4WBP5A may play a regulatory role in modulating Nedd4 activity at the level of the Golgi apparatus in T lymphocytes PMID: 12796489
    5. N4WBP5A acts as an adaptor to recruit Nedd4 family ubiquitin-protein ligases to the protein trafficking machinery PMID: 15252135
    6. Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them. PMID: 19343052

    顯示更多

    收起更多

  • 亞細胞定位:
    Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane.
  • 組織特異性:
    Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18537

    OMIM: 610041

    KEGG: hsa:54602

    STRING: 9606.ENSP00000218652

    UniGene: Hs.525093



主站蜘蛛池模板: 妺妺跟我一起洗澡没忍住| 亚洲精品色在线网站| 欧美在线看片a免费观看| 日韩精品一区二区三区在线观看l| 午夜肉伦伦影院| 国产成人久久av免费| 99精品视频九九精品视频| 国产精品丝袜久久久久久不卡| 日日摸日日碰夜夜爽免费| 女女女女女裸体开bbb| 无套内谢孕妇毛片免费看| 午夜精品久久久内射近拍高清| 亚洲色老汉av无码专区最 | 天天天天做夜夜夜夜做无码| 国产无遮挡又黄又爽动态图| gv天堂gv无码男同在线观看| 女人与拘性猛交视频| 久久99精品国产自在现线小黄鸭| 在线不卡av片免费观看| 久久av无码精品人妻糸列| 国产 一二三四五六| 国产亚洲熟妇在线视频| 三级做爰高清视频| 97色偷偷色噜噜狠狠爱网站| 亚洲精品无码mⅴ在线观看| 99精品久久久久中文字幕| 先锋影音男人av资源| 国产精品国产三级国快看| 无码一区二区三区在线观看| 久久亚洲国产精品123区| 免费无码又爽又刺激激情视频软件| 日韩欧美猛交xxxxx无码| 成人国产mv免费视频| 少妇被又大又粗又爽毛片| 国产精品v片在线观看不卡| 久久精品夜色噜噜亚洲a∨| 野花在线无码视频在线播放| 色欲网天天无码av| 2020精品国产自在现线看| 一卡二卡3卡4卡视频免费播放 | 影音先锋无码a∨男人资源站 |