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  4. Recombinant Human NACHT, LRR and PYD domains-containing protein 9 (NLRP9), partial

Recombinant Human NACHT, LRR and PYD domains-containing protein 9 (NLRP9), partial

  • 中文名稱：
    人NLRP9重組蛋白
  • 貨號：
    CSB-YP763002HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NLRP9重組蛋白
  • 貨號：
    CSB-EP763002HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NLRP9重組蛋白
  • 貨號：
    CSB-EP763002HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NLRP9重組蛋白
  • 貨號：
    CSB-BP763002HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NLRP9重組蛋白
  • 貨號：
    CSB-MP763002HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NLRP9
  • Uniprot No.：
  • 別名：
    NACHT, LRR and PYD domains-containing protein 9; NALP9_HUMAN; NLRP9; Nucleotide-binding oligomerization domain protein 6; PYRIN and NACHT-containing protein 12
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments.
  • 基因功能參考文獻：
    1. The Genetic variants located in NLRP9 have the potential to modulate disease course in MS patients and may be used as disease activity biomarkers to identify patients with divergent disease courses. PMID: 30217166
    2. Observational study of gene-disease association. (HuGE Navigator) PMID: 20403135
  • 亞細胞定位：
    Cytoplasm. Inflammasome.
  • 蛋白家族：
    NLRP family
  • 組織特異性：
    Expressed in ileum intestinal epithelial cells. Not detected in peripheral blood mononuclear cells. Expressed in cerebral endothelial cells and, at much lower levels, in brain pericytes.
  • 數據庫鏈接：

    HGNC: 22941

    OMIM: 609663

    KEGG: hsa:338321

    STRING: 9606.ENSP00000331857

    UniGene: Hs.661568



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