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  4. Recombinant Human NACHT, LRR and PYD domains-containing protein 4 (NLRP4), partial

Recombinant Human NACHT, LRR and PYD domains-containing protein 4 (NLRP4), partial

  • 中文名稱：
    人NLRP4重組蛋白
  • 貨號(hào)：
    CSB-YP839375HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NLRP4重組蛋白
  • 貨號(hào)：
    CSB-EP839375HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NLRP4重組蛋白
  • 貨號(hào)：
    CSB-EP839375HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NLRP4重組蛋白
  • 貨號(hào)：
    CSB-BP839375HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NLRP4重組蛋白
  • 貨號(hào)：
    CSB-MP839375HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NLRP4
  • Uniprot No.：
  • 別名：
    Cancer/testis antigen 58; CLR19.5; CT58; FLJ32126; NACHT, leucine rich repeat and PYD containing 4; NACHT, LRR and PYD containing protein 4; NACHT, LRR and PYD domains-containing protein 4; NALP4_HUMAN; NLR family, pyrin domain containing 4; NLRP4; Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 4; PAAD and NACHT containing protein 2; PAAD and NACHT-containing protein 2; PAN2; PYPAF4; PYRIN and NACHT-containing protein 2; PYRIN containing APAF1 like protein 4; PYRIN-containing APAF1-like protein 4; Ribonuclease inhibitor 2; RNH2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
  • 基因功能參考文獻(xiàn)：
    1. NLRP4 is an important mediator of cardiac remodeling in vitro and in vivo. PMID: 28486191
    2. This study describes conformational stability of native NLRP14 and mutants in their monomeric and dimeric states and compares them to NLRP4, a representative of a native pyrin domain fold. PMID: 25403012
    3. Structural and functional analysis of the NLRP4 pyrin domain. PMID: 22928810
    4. Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation. PMID: 22388039
    5. NLRP4 is recruited to and accumulates in bacteria-containing phagosomes and transiently dissociates from beclin1 following group A streptococcus infection, thereby controlling the autophagic flux crucial for cell-autonomous antibacterial resistance. PMID: 21209283

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  • 蛋白家族：
    NLRP family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 22943

    OMIM: 609645

    KEGG: hsa:147945

    STRING: 9606.ENSP00000301295

    UniGene: Hs.631533



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