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  4. Recombinant Human Myotubularin-related protein 4 (MTMR4), partial

Recombinant Human Myotubularin-related protein 4 (MTMR4), partial

  • 中文名稱：
    人MTMR4重組蛋白
  • 貨號：
    CSB-YP889148HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MTMR4重組蛋白
  • 貨號：
    CSB-EP889148HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MTMR4重組蛋白
  • 貨號：
    CSB-EP889148HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MTMR4重組蛋白
  • 貨號：
    CSB-BP889148HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MTMR4重組蛋白
  • 貨號：
    CSB-MP889148HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    FYVE domain containing dual specificity protein phosphatase 2; FYVE domain-containing dual specificity protein phosphatase 2; FYVE domain-containing dual specificity protein phosphatase FYVE DSP2; FYVE-DSP2; Mtmr4; MTMR4_HUMAN; Myotubularin related protein 4; Myotubularin-related protein 4; ZFYVE11 ; zinc finger FYVE domain containing 11; Zinc finger FYVE domain containing protein 11; Zinc finger FYVE domain-containing protein 11
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
  • 基因功能參考文獻：
    1. Here the authors demonstrate that green fluorescent protein-tagged MTMR4 is recruited to the Salmonella-containing vacuole and infection of cells depleted of endogenous MTMR4 results in a decrease in viable intracellular Salmonella. PMID: 27625994
    2. the PH-GRAM domain of human MTMR4 was cloned, overexpressed in Escherichia coli, purified and crystallized by the vapour-diffusion method PMID: 25195910
    3. MTMR4 is a necessary negative modulator for the homeostasis of BMP/Dpp signaling PMID: 23150675
    4. MTMR4 localizes at the interface of early and recycling endosomes to regulate trafficking. PMID: 20736309
    5. MTMR4 belongs to the myotubularin family of phosphoinositides phosphatases PMID: 9736772
    6. MTMR4 plays an important role in preventing the overactivation of TGFbeta signaling by dephosphorylating activated R-Smads that have been trafficked to early endosomes PMID: 20061380
    7. Data found that hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. PMID: 19125695

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  • 亞細胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
  • 組織特異性：
    Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.
  • 數據庫鏈接：

    HGNC: 7452

    OMIM: 603559

    KEGG: hsa:9110

    STRING: 9606.ENSP00000325285

    UniGene: Hs.514373



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