在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Myosin-2 (MYH2), partial

Recombinant Human Myosin-2 (MYH2), partial

  • 中文名稱：
    人MYH2重組蛋白
  • 貨號：
    CSB-YP892458HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MYH2重組蛋白
  • 貨號：
    CSB-EP892458HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MYH2重組蛋白
  • 貨號：
    CSB-EP892458HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MYH2重組蛋白
  • 貨號：
    CSB-BP892458HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MYH2重組蛋白
  • 貨號：
    CSB-MP892458HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MYH2
  • Uniprot No.：
  • 別名：
    adult 2; Fast 2a myosin heavy chain; IBM3; Inclusion body myopathy 3, autosomal dominant; MYH2; MYH2_HUMAN; MYH2A; MYHas8; MyHC IIa; MyHC-2a; MyHC-IIa; MYHSA2; Myosin heavy chain 2; Myosin heavy chain 2a; Myosin heavy chain; Myosin heavy chain IIa; Myosin heavy chain skeletal muscle adult 2; Myosin heavy polypeptide 2 skeletal muscle adult; Myosin-2; MYPOP; skeletal muscle; Type IIA myosin heavy chain
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Muscle contraction. Required for cytoskeleton organization.
  • 基因功能參考文獻：
    1. Exome analysis revealed homozygosity for a novel truncating mutation p.G800fs27* in the Myosin Heavy Chain 2 (MYH2) gene in both brothers, while parents and an unaffected sibling were heterozygous PMID: 28729039
    2. differential regulation of PKA and cell stiffness in unconfined versus confined cells is abrogated by dual, but not individual, inhibition of Piezo1 and myosin II. PMID: 27160899
    3. C-terminal Myosin IIA Heavy Chain phosphorylation sites are critical for recruitment of Myosin IIA to lamellar protrusions and for marginal paxillin phosphorylation during active cell spreading. PMID: 28053086
    4. Data shoe that five of the patients were homozygous for myosin heavy chain 2 (MYH2) missense mutations, one patient was compound heterozygous for a missense and a nonsense mutation and one patient was homozygous for a frame-shift MYH2 mutation. PMID: 24193343
    5. We have found that a greater MyH2 content in the vastus lateralis is accompanied by a higher oxygen cost of cycling during exercise performed below the lactate threshold. PMID: 24781731
    6. This study presented more case in MYH2 mutation in recessive myopathy with external ophthalmoplegia linked to chromosome 17p13.1-p12. PMID: 23388406
    7. A previously unrecognized interplay between actin and myosin IIA in podosomes, is demonstrated. PMID: 23361003
    8. Myosin heavy chain 2A transcripts decreased significantly in skeletal muscle tissue from overnight parenterally fed patients but did not change significantly in orally refed mice PMID: 23190566
    9. Phenotypic expression of alpha-smooth muscle actin, smooth muscle myosin heavy chain 2, and smoothelin were significantly decreased in the dissected media, whereas that of osteopontin was elevated. PMID: 22960022
    10. This study demonistrated that the missense mutation c.2542T>C (p.V805A) in the MYHC2A gene. PMID: 22349865
    11. The human genioglossus muscle is composed of conventional myosin heavy chain isoforms and 3 primary myosin hevy chain phenotypes. PMID: 22337492
    12. NMMII and actin isoform expression changes coordinately with the remodeling phase of repair, and NMMII is increased as matrix stiffness increases. As NMMII expression increases, so does the fibroblast contractility. PMID: 21102503
    13. Null mutations in the fast myosin heavy chain IIa gene cause early onset myopathy and demonstrate that this isoform is necessary for normal muscle development and function. PMID: 20418530
    14. investigated the relation between expression of the mutant MyHC IIa and pathologic changes in muscle PMID: 11889243
    15. Data suggest that changes in intracellular calcium may play a role in shifts in myosin heavy chain IIa (MyHC IIa) expression during muscle activation. PMID: 12235157
    16. IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression in cell differentiation PMID: 15496418
    17. analysis of normal variation indicates that there is strong selective pressure against mutations in MYH2; On the basis of these results, we suggest that MyHC genes should be regarded as candidate genes in hereditary myopathies of unknown etiology. PMID: 15741996
    18. Our results provide evidence that the pathogenesis of the MyHC IIa E706K myopathy involves defective function of the mutated myosin as well as alterations in the structural integrity of all muscle cells irrespective of MyHC isoform expression. PMID: 17005402
    19. myosin II has a role in glioma invasion of the brain PMID: 18495866

    顯示更多

    收起更多

  • 相關疾病：
    Myopathy, proximal, and ophthalmoplegia (MYPOP)
  • 亞細胞定位：
    Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 數據庫鏈接：

    HGNC: 7572

    OMIM: 160740

    KEGG: hsa:4620

    STRING: 9606.ENSP00000245503

    UniGene: Hs.667534



主站蜘蛛池模板： 国产三区在线成人av| 日日橹狠狠爱欧美视频| 久久午夜无码鲁丝片秋霞| 欧洲极品无码一区二区三区| 久久精品成人免费观看| 九九久久精品国产波多野结衣| 性xxxx欧美老妇胖老太性多毛| 一个人看的www片免费高清视频| 97人妻人人揉人人躁人人| 亚洲精品乱码久久久久久蜜桃不卡| 色综合天天天天综合狠狠爱| 日本xxx在线观看免费播放| 欧美三级a做爰在线观看| 人妻无码视频一区二区三区| 成人午夜又粗又硬又长| 国产熟妇疯狂4p交在线播放| 国产免费福利在线视频| 欧美做受又硬又粗又大视频| 欧美牲交40_50a欧美牲交aⅴ| 女人爽得直叫免费视频| 欧洲美女黑人粗性暴交视频| 亚洲综合无码一区二区痴汉| 日韩不卡1卡2卡三卡2021免费 | 精品国际久久久久999| 国产av无码专区亚洲草草| 玩弄人妻少妇老师美妇厨房 | 日韩精品久久无码中文字幕| 少妇性l交大片7724com| 无码av免费一区二区三区a片| 亚洲精品乱拍国产一区二区三区| 天天做天天爱夜夜爽毛片毛片| 亚洲人成电影在线观看影院| 亚洲最大成人综合网720p| 成人做爰视频www网站| 亚洲人成网亚洲欧洲无码| 在线观看无码不卡av| 国产精品久久无码不卡黑寡妇 | 人妻熟女一区二区aⅴ水野朝阳| 一区二区传媒有限公司| 2018国产大陆天天弄| 国产爆乳无码视频在线观看 |