在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Multiple epidermal growth factor-like domains protein 10 (MEGF10), partial

Recombinant Human Multiple epidermal growth factor-like domains protein 10 (MEGF10), partial

  • 中文名稱：
    人MEGF10重組蛋白
  • 貨號：
    CSB-YP822242HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MEGF10重組蛋白
  • 貨號：
    CSB-EP822242HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MEGF10重組蛋白
  • 貨號：
    CSB-EP822242HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MEGF10重組蛋白
  • 貨號：
    CSB-BP822242HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MEGF10重組蛋白
  • 貨號：
    CSB-MP822242HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MEGF10
  • Uniprot No.：
  • 別名：
    MEGF10; KIAA1780Multiple epidermal growth factor-like domains protein 10; Multiple EGF-like domains protein 10
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.
  • 基因功能參考文獻：
    1. Results suggested that methylation level and mRNA expression of MEGF10 in glioma were not only correlated with IDH mutation but also associated with clinical outcome of patients. PMID: 29887919
    2. Concentrating on hypermethylated genes to identify candidate tumor suppressor loci, the study found the cell engulfment and adhesion factor gene MEGF10 to be epigenetically repressed by DNA hypermethylation or by H3K27/K9 methylation in neuroblastoma cell lines. PMID: 27862318
    3. MEGF10 mutations can cause myopathy with adult-onset respiratory insufficiency PMID: 26802438
    4. results indicate that myogenin is a positive regulator in transcriptional regulation of MEGF10 in skeletal muscle PMID: 25044114
    5. Megf10 is required for preserving the undifferentiated, proliferative potential of satellite cells, myogenic precursors that regenerate skeletal muscle in response to injury or disease. PMID: 22371254
    6. Mutations in MEGF10 cause a recessive congenital myopathy with minicores and suggest satellite cell dysfunction as the pathogenic mechanism PMID: 22371254
    7. Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD) PMID: 22101682
    8. The results of this study suggested that no association between schizophrenia and rs27388 of the MEGF10 gene in Chinese case-control sample. PMID: 20813413
    9. MEGF10 is involved in the uptake of amyloid-beta peptide (Abeta42) in the brain. PMID: 20828568
    10. in a system of forced expression by transfection, MEGF10 function can be modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7 PMID: 17205124
    11. Human MEGF10 is an ortholog of Ced1. PMID: 17498693
    12. An interaction between MEGF10 and clathrin assembly protein complex 2 medium chain (AP50), a component of clathrin-coated pits was identified. PMID: 17643423
    13. In expression studies, MEGF10 had higher expression levels in the affected than the unaffected (p = .015). Schizophrenia patients with a 1/1 genotype at rs27388 had higher expressions than those patients with 1/2 and 2/2 genotypes (p = .0008). PMID: 18179784

    顯示更多

    收起更多

  • 相關疾病：
    Myopathy, early-onset, areflexia, respiratory distress, and dysphagia (EMARDD)
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, phagocytic cup.
  • 蛋白家族：
    MEGF family
  • 數據庫鏈接：

    HGNC: 29634

    OMIM: 612453

    KEGG: hsa:84466

    STRING: 9606.ENSP00000274473

    UniGene: Hs.438709



主站蜘蛛池模板： 免费不卡无码av在线观看| 中文字幕人妻伦伦| 国产高清卡1卡2卡3麻豆| 亚洲a∨国产av综合av网站| 国产偷国产偷亚洲清高网站| 99re6热在线精品视频播放| 亚洲成av人在线视| 精品久久久久久无码专区| 国产初高中生粉嫩无套第一次 | 天堂…中文在线最新版在线| 欧美高清在线精品一区| 香港三级日本三级a视频| 日韩欧国产精品一区综合无码| 亚洲精品一卡2卡三卡4卡| 国产国拍亚洲精品av在线| 波多野结衣绝顶大高潮| 日本少妇xxx做受| 欧美人妻少妇精品久久黑人| 人妻中文字幕无码专区| 亚洲vs日韩vs欧美vs久久| 丰满无码人妻熟妇无码区| 精品久久久久久久无码| 亚洲日韩精品a∨片无码加勒比| 国色精品卡一卡2卡3卡4卡在线| 99久久国产露脸精品竹菊传媒| 好吊妞国产欧美日韩免费观看| 色综合色综合久久综合频道88 | 狠狠色婷婷久久综合频道日韩| 337p日本大胆欧久久| 国产狂喷潮在线观看中文| av免费网址在线观看 | 日本无码人妻精品一区二区蜜桃| 久久精品www人人做人人爽| 色狠狠av老熟女| 久久久亚洲欧洲日产国码606| 免费无码午夜福利片69| 国产边打电话边被躁视频| 成人精品视频一区二区三区尤物 | 日本亲近相奷中文字幕| 少妇夜夜春夜夜爽试看视频| 亚洲一区二区av在线观看|