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  4. Recombinant Human Multiple PDZ domain protein (MPDZ), partial

Recombinant Human Multiple PDZ domain protein (MPDZ), partial

  • 中文名稱：
    人MPDZ重組蛋白
  • 貨號：
    CSB-YP014745HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MPDZ重組蛋白
  • 貨號：
    CSB-EP014745HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MPDZ重組蛋白
  • 貨號：
    CSB-EP014745HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MPDZ重組蛋白
  • 貨號：
    CSB-BP014745HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MPDZ重組蛋白
  • 貨號：
    CSB-MP014745HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MPDZ
  • Uniprot No.：
  • 別名：
    MPDZ; MUPP1; Multiple PDZ domain protein; Multi-PDZ domain protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Promotes clustering of HT2RC at the cell surface.
  • 基因功能參考文獻：
    1. two peptides (SIAPNV(-COOH) and SIVMNV(-COOH)) were identified to have considerably improved affinity with K d increase by ~tenfold relative to wild type peptide. Thus, the two peptides are considered as promising lead entities to develop therapeutic molecular agents with high efficacy and specificity to target CaMKIIalpha-MUPP1 interaction. PMID: 26984442
    2. Phenotypic spectrum of congenital hydrocephalus is associated with 5 recessive MPDZ alleles. PMID: 28556411
    3. The replication association of rs1324183 (MPDZ-NF1B) with KC in our population and the results, which are identical to those in different populations, suggest that rs1324183 (MPDZ-NF1B) is a common genetic risk for Keratoconus. PMID: 25675348
    4. MUPP-1 controls the PALS-1/PATJ complex levels at the post-translational level. PMID: 23880463
    5. Our data strongly support the candidacy of MPDZ as a novel congenital hydrocephalus disease gene. PMID: 23240096
    6. The data indicates potential association between variation in mpdz NMDA dependent AMPA trafficking and alcohol dependence. PMID: 21762291
    7. Results indicate that the coxsackievirus and adenovirus receptor interacts with multi-PDZ domain protein 1 (MUPP1) and is involved in MUPP1 recruitment to the tight junction. PMID: 15364909
    8. The predominant expression profile of MUPP1 in sperm in the apical acrosomal region of different mammalian species suggests that this PDZ-domain protein may be involved in organizing signaling molecules mediating primary reactions of fertilization. PMID: 16452527
    9. The results revealed prominent MUPP1 expression which was restricted to the apical acrosomal region and, most notably, to the equatorial segment of the acrosome[MUPP1] PMID: 16452527
    10. MUPP1 binds to the G protein-coupled MT(1) melatonin receptor and directly regulates its G(i)-dependent signal transduction PMID: 18378672
    11. An interaction between the human somatostatin receptor 3 and the multiple PDZ protein MUPP1 was identified. PMID: 19071123
    12. Exploratory haplotype and single nucleotide polymorphisms association analyses suggest a possible association between the MPDZ gene and alcohol dependence but not alcohol withdrawal seizures. PMID: 19175764
    13. Results suggest that signaling mediated by Pals1, which has a higher affinity for Patj than for MUPP1 and is involved in the activation of the Par6-aPKC complex, is of principal importance for the function of Patj in epithelial cells. PMID: 19255144
    14. MUPP1 and Kir4.2 may participate in a protein complex in the nephron that could regulate transport of K(+) as well as other ions. PMID: 19420109
    15. These data suggest that NMDA receptor complex formation, localization, and downstream signaling may be abnormal in schizophrenia as PSD95, SynGAP and MUPP1 expression is altered. PMID: 19483657
    16. the apparent occurrence of an unusual TG 3' splice site in intron 39 is discussed PMID: 17672918

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  • 相關疾病：
    Hydrocephalus, non-syndromic, autosomal recessive 2 (HYC2)
  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome.
  • 組織特異性：
    Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 7208

    OMIM: 603785

    KEGG: hsa:8777

    STRING: 9606.ENSP00000370410

    UniGene: Hs.169378



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