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  4. Recombinant Human Multiple C2 and transmembrane domain-containing protein 2 (MCTP2), partial

Recombinant Human Multiple C2 and transmembrane domain-containing protein 2 (MCTP2), partial

  • 中文名稱：
    人MCTP2重組蛋白
  • 貨號：
    CSB-YP738576HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MCTP2重組蛋白
  • 貨號：
    CSB-EP738576HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MCTP2重組蛋白
  • 貨號：
    CSB-EP738576HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MCTP2重組蛋白
  • 貨號：
    CSB-BP738576HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MCTP2重組蛋白
  • 貨號：
    CSB-MP738576HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MCTP2
  • Uniprot No.：
  • 別名：
    MCTP2Multiple C2 and transmembrane domain-containing protein 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Might play a role in the development of cardiac outflow tract.
  • 基因功能參考文獻：
    1. Results identify MCTP2 as a novel genetic cause of coarctation of the aorta and related cardiac malformations. PMID: 23773997
    2. MCTPs are evolutionarily conserved C2 domain proteins that are unusual in that the C2 domains are anchored in the membrane by two closely spaced transmembrane regions and represent Ca(2+)-binding but not phospholipid-binding modules PMID: 15528213
    3. The present study suggested that MCPT2 gene as aputative susceptibility gene for schizophrenia of Scandinavian origin. PMID: 19223264
  • 相關疾?。?/div>
    Heterozygosity for a 2.2-Mb deletion at chromosome 15q26.2, encompassing MCTP2, has been identified in a 10-year-old girl and her 3-year-old half brother, who had both coarctation of the aorta associated with dysmorphic features and ventricular septal defects. An intragenic MCTP2 duplication, leading to premature truncation (F697X) within the first transmembrane region of the protein, has also been observed in a male patient with a non-syndromic complex cardiac malformation involving coarctation, hypoplastic left heart, mitral atresia, bicuspid aortic valve and muscular ventricular septal defect. Although the link between left ventricular outflow tract malformations and MCTP2 could not be established, it has been proposed that defects in the MCTP2 gene may contribute to phenotype. This hypothesis is supported by the observation that Xenopus laevis embryos treated with MCTP2 morpholinos show no evidence of endocardial cushion formation at any level of the developing outflow tract (PubMed:23773997).
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MCTP family
  • 數據庫鏈接：

    HGNC: 25636

    OMIM: 616297

    KEGG: hsa:55784

    STRING: 9606.ENSP00000350377

    UniGene: Hs.33368



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