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  4. Recombinant Human Mitogen-activated protein kinase kinase kinase 1 (MAP3K1), partial

Recombinant Human Mitogen-activated protein kinase kinase kinase 1 (MAP3K1), partial

  • 中文名稱：
    人MAP3K1重組蛋白
  • 貨號：
    CSB-YP013417HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MAP3K1重組蛋白
  • 貨號：
    CSB-EP013417HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MAP3K1重組蛋白
  • 貨號：
    CSB-EP013417HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MAP3K1重組蛋白
  • 貨號：
    CSB-BP013417HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MAP3K1重組蛋白
  • 貨號：
    CSB-MP013417HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    M3K1_HUMAN; MAP3K1; MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; MEKK 1; Mekk; MEKK1; Mitogen activated protein kinase kinase kinase 1; Mitogen activated protein kinase kinase kinase 1; E3 ubiquitin protein ligase; Mitogen-activated protein kinase kinase kinase 1; SRXY6
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
  • 基因功能參考文獻：
    1. Through a stratification analysis, 5q11.2/MAP3K1 (rs16886034, rs16886364, rs16886397, rs1017226, rs16886448) and 7q32.3/LINC-PINT (rs4593472) were associated with Luminal A, and 10q26.1/FGFR2 (rs35054928) was associated with Luminal B. PMID: 28408616
    2. findings show a robust association between the variant allele of rs832582 (MAP3K1906Val) and decreased VFDs in patients with ARDS and suggest that this variant may predispose individuals to a greater inflammatory response. PMID: 28858533
    3. We have revealed significant association of FGFR2 and MAP3K1 polymorphisms with breast cancer. PMID: 29372690
    4. Identification of a MAP3K1 variant should prompt an evaluation for disorders of sex development in female siblings of the proband PMID: 28504475
    5. Polymorphism of MAP3K1 is associated with breast cancer. PMID: 28178648
    6. SNP variants at the MAP3K1/SETD9 gene boundary associate with somatic PIK3CA variants in breast cancers. PMID: 28029147
    7. CSN6 positively regulates c-Jun in a MEKK1-dependent manner PMID: 26237449
    8. BAALC conferred chemoresistance in acute myeloid leukemia cells by upregulating ATP-binding cassette proteins in an ERK-dependent manner, which can be therapeutically targeted by MEK inhibitor PMID: 26050649
    9. MiR-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D and MAP3K1 expression. PMID: 26019450
    10. There were 3 specimens with mutations in MAP3K1 (MEKK1), including two truncation mutants, T779fs and T1481fs; T1481fs encoded an unstable and nonfunctional protein when expressed in vitro. PMID: 25899310
    11. Results demonstrate that MAP3K1 rs889312 is closely correlated with outcome among diffuse-type gastric cancer in a Chinese population. PMID: 24759887
    12. We propose that the cancer risk alleles act to increase MAP3K1 expression in vivo and might promote breast cancer cell survival. PMID: 25529635
    13. The present meta-analysis suggests that MAPKKK1 rs889312-C allele and rs16886165-G allele might be risk factors for breast cancer, especially in Europeans and Asians. PMID: 24595411
    14. MAP3K1 mutations tilt the balance in the sex-determining pathways by downregulating SOX9 and FGF9. PMID: 24135036
    15. MAP3K1 protein expression level in breast cancer cells was higher than that in normal mammary gland cells. PMID: 24253898
    16. MAP3K1 single nucleotide polymorphism rs889312 was confirmed to be associated with breast cancer risk (P = 0.04, OR 1.15, 95% CI 1.01-1.30). PMID: 23634849
    17. FGFR2 and MAP3K1 SNPs have an additive effect on an increased risk of familial breast cancer in a South-American population. PMID: 23225170
    18. We also observed that four Single Nucleotide Polymorphisms (SNPs) were associated with severe asthma PMID: 22468730
    19. High MEK1 is associated with hepatocellular carcinoma. PMID: 22110214
    20. Novel phosphorylation-dependent ubiquitination of tristetraprolin by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1) and tumor necrosis factor receptor-associated factor 2 (TRAF2) PMID: 21921033
    21. Apoptosis induced by cytoskeletal disruption requires distinct domains of MEKK1. PMID: 21364884
    22. MAP3K1 rs889312 polymorphism is associated with increased risk of breast cancer in BRCA1 mutation carriers PMID: 20809358
    23. The upstream molecule of the TRAIL-induced MAPK activation is MEKK, as opposed to ASK1, via the mediation of its signal through JNK/p38 in a caspase-8-dependent manner. PMID: 21152872
    24. Data show that MEKK-1 plays an integral role in IL-1beta modulation of Caco-2 TJ barrier function by regulating the activation of the canonical NF-kappaB pathway and the MLCK gene. PMID: 21048223
    25. mutations in MAP3K1 that result in 46,XY DSD with partial or complete gonadal dysgenesis implicate this pathway in normal human sex determination PMID: 21129722
    26. MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein PMID: 20923779
    27. Han11 was required to allow coupling of MEKK1 to DYRK1 and HIPK2. PMID: 20940704
    28. These results of MAP3K1, previously reported as an Axin1 inter-actor in c-Jun NH(2)-terminal kinase pathway, is also involved in the canonical Wnt signalling pathway and positively regulates expression of Wnt target genes. PMID: 20128690
    29. Modulation of human cytomegalovirus immediate early gene enhancer and promoter activity by MEKK1 is under the control of the NFkappaB/rel sites. PMID: 11746500
    30. MEK kinase 1 induces mitochondrial permeability transition leading to apoptosis PMID: 11756439
    31. caspase cleavage of MEKK1 is a dynamic regulatory mechanism that alters the subcellular distribution of MEKK1, changing its function to pro-apoptotic signaling PMID: 11782455
    32. Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells PMID: 11903060
    33. Results suggest that the conserved AR acetylation site contributes to a pathway governing prostate cancer cellular survival, as AR acetylation mutants are defective in MEKK1-induced apoptosis. PMID: 11971970
    34. Results show that oncogenic ras provokes premature senescence by sequentially activating the MEK-ERK and MKK3/6-p38 pathways in normal, primary cells. PMID: 11971971
    35. the NOx-induced cell proliferation via activation of MEKK1 might contribute to lung tissue damage caused by NOx PMID: 12079429
    36. The difference of suppression in pancreatic cancer cells and non-pancreatic cancer cells suggested that the MEKK1 pathway mainly contributes to cell survival in pancreatic cancer cells PMID: 12185592
    37. mechanism by which the MEKK1-dependent JNK/SAPK pathway is negatively regulated by PAK through phosphorylation of serine 67 PMID: 12228228
    38. Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways PMID: 12456688
    39. MEKK1 is activated by GSK3beta PMID: 12584189
    40. Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. PMID: 12878610
    41. subdomain VIII of MEKK1 is involved not only in binding to, but also in discrimination of, protein substrates PMID: 14500727
    42. coexpression of constitutive-active MEKK1 inhibited orphan receptor TR3 transcriptional activity and TR3-induced proliferation in lung cancer cells PMID: 14612408
    43. The G(i)-Ras-MEKK1 signaling pathway mediates lysophosphatidic acid-stimulated ovarian cancer cell migration by facilitating focal adhesion kinase redistribution to focal contacts. PMID: 15205333
    44. glutathione s-transferaase Mu suppresses MEKK1-mediated apoptosis and functions as a negative regulator of MEKK1. PMID: 15299005
    45. MEKK1 plays a key role in Bcr-Abl-induced STAT3 activation and in ES cells' capacity for LIF-independent self-renewal and may thus be involved in Bcr-Abl-mediated leukemogenesis in stem cells PMID: 16044153
    46. Galpha13-induced VASP phosphorylation that involves activation of RhoA and MEKK1, phosphorylation and degradation of IkappaB, release of PKA catalytic subunit from the complex with IkappaB and NF-kappaB, and subsequent phosphorylation of VASP PMID: 16046415
    47. Induction of Nur77 nuclear export by MEKK1 required a prolonged MEKK1 activation and was attenuated by Akt activation. Expression of constitutively active Akt prevented MEKK1-induced Nur77 nuclear export. PMID: 16434970
    48. Pge2 abolished the MEKK1-induced MMP-1 promoter luciferase activity. PMID: 16714289
    49. MEKK1 transmits wound signals, leading to the transcriptional activation of genes involved in Extracellular Matrix homeostasis, epithelial cell migration, and wound reepithelialization. PMID: 16760432
    50. Caspase-3 and the p38alpha MAP kinase were activated during TIMP-1-induced UT-7 cells erythroid differentiation. PMID: 17301822

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  • 相關(guān)疾病：
    46,XY sex reversal 6 (SRXY6)
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6848

    OMIM: 600982

    KEGG: hsa:4214

    STRING: 9606.ENSP00000382423

    UniGene: Hs.653654



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