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  4. Recombinant Human Mitochondrial inner membrane protease subunit 2 (IMMP2L), partial

Recombinant Human Mitochondrial inner membrane protease subunit 2 (IMMP2L), partial

  • 中文名稱：
    人IMMP2L重組蛋白
  • 貨號：
    CSB-YP822306HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人IMMP2L重組蛋白
  • 貨號：
    CSB-EP822306HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人IMMP2L重組蛋白
  • 貨號：
    CSB-EP822306HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人IMMP2L重組蛋白
  • 貨號：
    CSB-BP822306HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人IMMP2L重組蛋白
  • 貨號：
    CSB-MP822306HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    IMMP2L
  • Uniprot No.：
  • 別名：
    IMMP2L; Mitochondrial inner membrane protease subunit 2; IMP2-like protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
  • 基因功能參考文獻：
    1. While the IMMP2L deletions carried non-recurrent breakpoints, in contrast to previous reports, meta-analysis found no evidence of association (P > 0.05) between IMMP2L deletions and ASD. We also observed common exonic deletions impacting IMMP2L in a separate control (5,971 samples) cohort where subjects were screened for psychiatric conditions. PMID: 29152845
    2. data would indicate that deletions involving the IMMP2L gene may contribute to the development of a subgroup of cognitive/behavioral disorders PMID: 29788020
    3. Deficiency of IMMP2L in cells cultured under hypoxia and high glucose, exacerbated neuronal death. PMID: 28316022
    4. Chromosomal breakpoints involved the IMMP2L gene in 7q31 is associated with Diffuse Large B-Cell Lymphomas. PMID: 27356265
    5. IMMP2L transcription requires Topoisomerase I in human primary astrocytes PMID: 27932244
    6. genomic rearrangements affecting IMMP2L may be one of the predisposing factors involved in Tourette syndrome and overlapping neurodevelopmental disorders. PMID: 24549057
    7. AUTS1/AUTS5 linkage to immp2l-dock4 may be involved in autism susceptibility PMID: 19401682

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  • 相關疾病：
    Gilles de la Tourette syndrome (GTS)
  • 亞細胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    Peptidase S26 family, IMP2 subfamily
  • 組織特異性：
    Expressed in all tissues tested except adult liver and lung.
  • 數據庫鏈接：

    HGNC: 14598

    OMIM: 137580

    KEGG: hsa:83943

    STRING: 9606.ENSP00000329553

    UniGene: Hs.655722



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