在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Mimecan (OGN)

In Stock
  • 中文名稱:
    人OGN重組蛋白
  • 貨號(hào):
    CSB-EP016314HU
  • 規(guī)格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP016314HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) OGN.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP016314HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) OGN.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    OGN
  • Uniprot No.:
  • 別名:
    Corneal keratan sulfate proteoglycan; DKFZP586P2421; MIME_HUMAN; Mimecan; Mimecan proteoglycan; OG; OGN; OIF; Osteoglycin; Osteoinductive factor; SLRR3A
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Full Length of Mature Protein
  • 來(lái)源:
    E.coli
  • 分子量:
    35.7kDa
  • 表達(dá)區(qū)域:
    21-298aa
  • 氨基酸序列
    PPTQQDSRIIYDYGTDNFEESIFSQDYEDKYLDGKNIKEKETVIIPNEKSLQLQKDEAITPLPPKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADIPNLRRLDFTGNLIEDIEDGTFSKLSLLEELSLAENQLLKLPVLPPKLTLFNAKYNKIKSRGIKANAFKKLNNLTFLYLDHNALESVPLNLPESLRVIHLQFNNIASITDDTFCKANDTSYIRDRIEEIRLEGNPIVLGKHPNSFICLKRLPIGSYF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
  • 基因功能參考文獻(xiàn):
    1. OGN expression is positively associated with CD8+ cell density in colorectal cancer tissue, suggesting a possible influence of OGN expression on tumor reactive T cells in the tumor niche. PMID: 30037719
    2. Results provide evidence that osteoglycin expression is increased in the heart in response to pressure overload and its absence results in increased cardiac inflammation and fibrosis resulting in increased diastolic dysfunction. PMID: 28958774
    3. OGN identified as a novel oncogene in meningioma proliferation. PMID: 28931407
    4. serum osteoglycin is a potential predictor of adverse outcomes in patients with chronic kidney disease. PMID: 28824047
    5. NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin and osteoglycin. PMID: 29262349
    6. Increased serum mimecan is associated with poor angiographic coronary collateralization in patients with chronic total occlusion PMID: 27508318
    7. the association of serum OGN and FAM5C levels and muscle mass with bone mineral density (BMD), bone turnover markers, and the presence of vertebral fractures (VFs) in 156 postmenopausal women with type 2 diabetes mellitus, is reported. PMID: 27836731
    8. OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF-VEGFR2 signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration. PMID: 28069703
    9. The current study discovered a novel 72-kDa chondroitin sulfate-OGN that is specific for innate immune cells. This variant is able to bind and activate TLR4. PMID: 27878326
    10. mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1beta and IL-6 expression in the hypothalamus. PMID: 26870797
    11. Increased plasma mimecan levels are independently associated with increased arterial stiffness in hypertensive patients. PMID: 26206738
    12. OIF may be an indicator of the earlier-stage diabetic nephropathy in subjects with type 2 diabetes mellitus PMID: 26045825
    13. OGN might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC. PMID: 25953442
    14. The lack of the proteoglycan OGN does not affect the progression of atherosclerosis in mice. Possible causes for the absence of phenotype in the Apoe/Ogn double mutants are discussed. PMID: 25463067
    15. Circulating OGN and NGAL/MMP9 complex are promising biomarkers that are expressed in vulnerable atherosclerotic plaques and may have incremental value for prediction of MACE within 1 year after coronary angiography. PMID: 24651681
    16. We found that IGF-2 and IGFBP2 synergistically increased neurite outgrowth via enhanced early signaling through the IGF type 1 receptor. PMID: 23714241
    17. This work provides insight into the regulating mechanism of mimecan in pituitary and suggests that mimecan may be an unidentified pituitary secretory protein, and certain pituitary cells secreting ACTH or GH also secrete mimecan. PMID: 16189248
    18. All adenoma and cancer tissues did not express mimecan, but all normal mucosa did (P < 0.01). PMID: 17895523
    19. High expression in the cochlea may be suggestive of a fundamental role for a transcript in the auditory system PMID: 18243607
    20. Includes the characterization of two human splice variants. PMID: 10373482

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族:
    Small leucine-rich proteoglycan (SLRP) family, SLRP class III subfamily
  • 組織特異性:
    Bone.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 8126

    OMIM: 602383

    KEGG: hsa:4969

    STRING: 9606.ENSP00000262551

    UniGene: Hs.109439



主站蜘蛛池模板: 国产高清在线a视频大全| 999精品无码a片在线1级| 久久久久99精品成人片试看| 国产精品露脸国语对白| 亚洲一区无码中文字幕乱码 | 无码免费无线观看在线视| 亚洲欲色欲香天天综合网| 领导边摸边吃奶边做爽在线观看| 免费观看18禁无遮挡真人网站 | 天堂√最新版中文在线地址| 伊在人天堂亚洲香蕉精品区| 国产精品成人观看视频国产奇米 | 又爽又黄无遮拦成人网站| 成 人 免 费 黄 色| 两女女百合互慰av赤裸无遮挡| 欧美肥胖老妇bbw| 极品粉嫩国产18尤物在线观看| 亚洲aⅴ天堂av天堂无码app| 中国少妇内射xxxhd免费| 波多野结衣50连登视频| 国产揄拍国产精品| 97人人超碰国产精品最新| 日本爽爽爽爽爽爽在线观看免 | 久久精品国产只有精品96| av片在线观看| 久久久久久毛片免费播放| 女同免费毛片在线播放| 国产av无码专区影视| 18禁高潮出水呻吟娇喘蜜芽| 久久婷婷五月综合97色直播| 日韩精品一卡2卡3卡4卡新区| 国产热re99久久6国产精品首页 | 亚洲人亚洲人成电影网站色| 国产成人无码性教育视频| 在线观看片免费人成视频播放| 美女扒开腿让男人桶爽app免费看 精品国产免费人成电影在线看 | 久久国产欧美成人网站| 成人久久久久久久久久久| 国产69精品久久久久777| 久久久久久久波多野结衣高潮| 免费网站看sm调教视频|