在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Mesoderm-specific transcript homolog protein (MEST), partial

Recombinant Human Mesoderm-specific transcript homolog protein (MEST), partial

  • 中文名稱：
    人MEST重組蛋白
  • 貨號：
    CSB-YP704858HU1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MEST重組蛋白
  • 貨號：
    CSB-EP704858HU1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MEST重組蛋白
  • 貨號：
    CSB-EP704858HU1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MEST重組蛋白
  • 貨號：
    CSB-BP704858HU1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MEST重組蛋白
  • 貨號：
    CSB-MP704858HU1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MEST
  • Uniprot No.：
  • 別名：
    MEST; PEG1; Mesoderm-specific transcript homolog protein; Paternally-expressed gene 1 protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻：
    1. We conclude methylation changes at some CpG sites of MEST and DLK differentially methylated regions in preeclamptic group PMID: 29157033
    2. Some growth-regulating imprinted genes such as MEST and MEG3, are susceptible to non-imprinted allele during development and differentiation, whereas the intergenic differentially methylated region of others (i.e. PEG3) are strictly maintained. PMID: 28854270
    3. strongly expressed in invasive extravillous trophoblasts during the first trimester PMID: 27697227
    4. G4 formation at motifs not previously identified through bioinformatic analysis of the MEST promoter, is reported. PMID: 28052120
    5. altered DNA methylation at imprinted domains including IGF2/H19 and PEG1/MEST may mediate the association between human papillomavirus infection and invasive cervical cancer PMID: 23775149
    6. The expression levels of miR-335 significantly correlated with those of MEST, supporting the notion that the intronic miR-335 is co-expressed with its host gene PMID: 23229728
    7. DNA methylation level at the H19 and MEST differentially methylated regions (DMRs)is reduced in placentas from pregnancies conceived by IVF/ICSI when compared with placentas from spontaneous conception. PMID: 23343754
    8. Paternal methylation aberrations at imprinting control regions of DLK1-GTL2, MEST (PEG1), and ZAC (PLAGL1) and global methylation levels are not associated with idiopathic recurrent spontaneous miscarriages. PMID: 23415968
    9. These results support the idea that intrauterine exposure to gestational diabetes mellitus has long-lasting effects on the epigenome of the offspring. PMID: 23209187
    10. MEST showed tissue-specific imprinting, being paternally expressed in skeletal muscle, fat, pituitary gland, heart, kidney, lung, stomach and uterus, and maternally expressed in spleen and liver. PMID: 22531794
    11. In cortices, the MEST promoter was hemimethylated, as expected for a differentially methylated imprinting control region, whereas the COPG2 and TSGA14 promoters were completely demethylated, typical for transcriptionally active non-imprinted genes. PMID: 22456293
    12. Regardless of conception method, the PEG1 methylation percentage in chorionic villus from spontaneous abortions is significantly higher than in villus from induced abortions and multifetal reduction. PMID: 21575949
    13. data demonstrated that tumorigenesis of leiomyoma is associated with overexpression of isoform 1 of PEG1/MEST gene, but not with loss of imprinting of the gene PMID: 20339302
    14. MEST gene is imprinted in an isoform-specific manner in adult lymphocytes. PMID: 10631159
    15. MEST gene is imprinted, with preferential expression from the paternal allele in fetal tissues. PMID: 9192843
    16. Findings suggest that PEG1/MEST can be excluded as a major determinant of Silver-Russell syndrome. PMID: 11754049
    17. An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. PMID: 11821432
    18. Mutation screening and imprinting analysis of candidate genes for autism in the 7q32 region PMID: 11920156
    19. a novel mechanism /promoter switch/ leading to biallelic expression in invasive breast cancer PMID: 12023987
    20. An intron contains a sequence, MESTIT1, which is transcribed only from the paternal allele, may be involved in MEST regulation PMID: 12095916
    21. Lof imprinting of PEG1/MESTOI may be related to tumorigenesis and malignant transformation, especially in NSCLC PMID: 15547750
    22. PEG1 isoform 2 is in fact imprinted in a large subset of human placentae. PMID: 16338457
    23. Hypermethylation of paternally expressed genes including PEG1/MEST, which have growth-promoting effects, may be relevant to low birth weight in subjects conceived by assisted reproduction techniques. PMID: 17450433
    24. Type of epimutation at the PEG1/MEST locus does not play a relevant role in Silver-Russell syndrome. PMID: 18585117
    25. MEST is localized to the endoplasmic reticulum/Golgi apparatus where its putative enzymatic properties as a lipase or acyltransferase, predicted from sequence homology with members of the alpha/beta fold hydrolase superfamily. PMID: 18644838

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    AB hydrolase superfamily
  • 組織特異性：
    Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is exp
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7028

    OMIM: 601029

    KEGG: hsa:4232

    STRING: 9606.ENSP00000223215

    UniGene: Hs.270978



主站蜘蛛池模板： 日韩av无码一区二区三区无码| 好吊色欧美一区二区三区视频 | 精品无码黑人又粗又大又长| 18禁无遮挡免费视频网站| 99久久无色码中文字幕| 一区二区视频传媒有限公司 | 国产99久久亚洲综合精品西瓜tv| 国产麻豆精品福利在线| 男人靠女人的免费视频| 亚洲视频一区| 日韩一本之道一区中文字幕| 亚洲337少妇裸体艺术| 国产精品视频观看裸模| 热99re久久精品这里都是精品免费 | 131mm少妇做爰视频| 欧美伊人久久大香线蕉综合| 一线二线三线天堂| 天天做天天大爽天天爱| 丁香五月综合久久激情| 国产精品一区二区高清在线| 国产老熟女伦老熟妇露脸 | 96亚洲精华国产精华精华液| 青草草在线视频永久免费| 亚洲欧美日韩综合久久久| 在线偷着国产精选视频| 把腿张开老子臊烂你多p视频| 久久婷婷成人综合色| 精品无码国产污污污免费网站| 国产精品亚洲成在人线| av区无码字幕中文色| 少妇人妻无码专区视频| 国产精品天干天干有线观看| 精品无码av不卡一区二区三区| 日韩精品一卡2卡3卡4卡新区 | 免费无码毛片一区二区app| 久久aⅴ无码av高潮av喷吹| 日本一区二区三区免费播放视频站| 被黑人猛躁10次高潮视频| 久久亚洲精品11p| 久久激情日本亚洲欧洲国产中文| 又色又爽又黄的美女裸体网站|