在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Melanophilin (MLPH)

  • 中文名稱:
    人MLPH重組蛋白
  • 貨號:
    CSB-YP014640HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人MLPH重組蛋白
  • 貨號:
    CSB-EP014640HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人MLPH重組蛋白
  • 貨號:
    CSB-EP014640HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人MLPH重組蛋白
  • 貨號:
    CSB-BP014640HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人MLPH重組蛋白
  • 貨號:
    CSB-MP014640HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    MLPH
  • Uniprot No.:
  • 別名:
    2210418F23Rik; 5031433I09Rik; AW228792; D1Wsu84e; Exophilin 3; Exophilin-3; l(1)-3Rk; l1Rk3; Leaden; Leaden protein; ln; Melanophilin; MELPH_HUMAN; MGC2771; MGC59733; Mlph; Slac 2a; SlaC2-a; Slp homolog lacking C2 domains a; Synaptotagmin like protein 2a; Synaptotagmin like protein lacking C2 domains A; Synaptotagmin-like protein 2a
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-600
  • 氨基酸序列
    MGKKLDLSKL TDEEAQHVLE VVQRDFDLRR KEEERLEALK GKIKKESSKR ELLSDTAHLN ETHCARCLQP YQLLVNSKRQ CLECGLFTCK SCGRVHPEEQ GWICDPCHLA RVVKIGSLEW YYEHVKARFK RFGSAKVIRS LHGRLQGGAG PELISEERSG DSDQTDEDGE PGSEAQAQAQ PFGSKKKRLL SVHDFDFEGD SDDSTQPQGH SLHLSSVPEA RDSPQSLTDE SCSEKAAPHK AEGLEEADTG ASGCHSHPEE QPTSISPSRH GALAELCPPG GSHRMALGTA AALGSNVIRN EQLPLQYLAD VDTSDEESIR AHVMASHHSK RRGRASSESQ IFELNKHISA VECLLTYLEN TVVPPLAKGL GAGVRTEADV EEEALRRKLE ELTSNVSDQE TSSEEEEAKD EKAEPNRDKS VGPLPQADPE VGTAAHQTNR QEKSPQDPGD PVQYNRTTDE ELSELEDRVA VTASEVQQAE SEVSDIESRI AALRAAGLTV KPSGKPRRKS NLPIFLPRVA GKLGKRPEDP NADPSSEAKA MAVPYLLRRK FSNSLKSQGK DDDSFDRKSV YRGSLTQRNP NARKGMASHT FAKPVVAHQS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
  • 基因功能參考文獻:
    1. A novel Rab27a mutation binds melanophilin, but not Munc13-4, causing immunodeficiency without albinism. PMID: 27016801
    2. we detected two potential associations with well-recognized skin cancer risk traits that modify miRNA-mRNA interactions: rs2325814 in the 3'UTR of the MLPH gene and rs752107 in the 3'UTR of the WNT3A gene. PMID: 28266728
    3. These results unravel a hidden link between AR and a functional putative PCa risk SNP, whose allele alteration affects androgen regulation of its host gene MLPH. PMID: 26411452
    4. The results showed that Rab27A(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A effector Slac2-a/melanophilin. PMID: 24584932
    5. The pathologic defect in Griscelli syndrome 3 came from the MLPH R35W substitution, which induced aggregation of melanosomes in the perinuclear area of melanocytes because of failure to interact with RAB27A. PMID: 21883982
    6. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport PMID: 11856727
    7. links rab27a and myosin Va function in melanosome transport PMID: 11980908
    8. Melanophilin has a role in bridging Rab27a on melanosomes and myosin Va on actin filaments during melanosome transport. PMID: 12062444
    9. SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP-bound form of Rab27A PMID: 12189142
    10. Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1). PMID: 12897212
    11. deletion 2q37.3 is implicated in autism PMID: 15517821
    12. The C-terminus of Slac2-a/melanophilin contains a novel actin-binding site, which may be involved in capture of Rab27-containing organelles in the actin-enriched cell periphery. PMID: 12221080
    13. Slac2-a/melanophilin contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slac2-a specifically and directly binds the GTP-bound form of Rab27A and Rab27B (PMID: 11773082). The C-terminus of Slac2-a directly binds myosin Va. PMID: 11856727

    顯示更多

    收起更多

  • 相關疾病:
    Griscelli syndrome 3 (GS3)
  • 亞細胞定位:
    Cytoplasm.
  • 數據庫鏈接:

    HGNC: 29643

    OMIM: 606526

    KEGG: hsa:79083

    STRING: 9606.ENSP00000264605

    UniGene: Hs.102406



主站蜘蛛池模板: 国产成人无码免费视频麻豆 | 4hu四虎永久免费地址ww416| 欧美三级欧美成人高清| 精品国产乱码久久久久久乱码| 久久99精品久久久久久蜜芽 | 被窝影院午夜无码国产| 久久日本片精品aaaaa国产| 欧美又大又硬又粗bbbbb| 骚虎视频在线观看| 77se77亚洲欧美在线| 久久精品无码av| 日韩av激情在线观看| 久艹视频免费看| 一区二区三区四区在线不卡高清| 亚洲一区二区三区四区五区六区 | 亚洲桃色天堂网| 色妞www精品视频| 老妇肥熟凸凹丰满刺激| 国产色青青视频在线观看撒| 亚洲另类色区欧美日韩图片 | 国产精品美女久久久久av爽| 亚洲大尺度无码无码专线一区| 香蕉欧美成人精品a∨在线观看| 欧美国产亚洲日韩在线二区| 中文字幕人妻色偷偷久久| 天堂资源中文网| 吃奶摸下高潮60分钟免费视频| 337p日本欧洲亚洲大胆在线| 92电影网午夜福利| 在线岛国片免费无码av| 无码人妻斩一区二区三区| 中国孕妇变态孕交xxxx| 九九九国产精品成人免费视频| 亚洲欧美在线制服丝袜国产| 亚洲人成色777777老人头| 亚洲精品成人a在线观看| 国产永久免费观看的黄网站| 精品无码一区二区三区av| 亚洲精品久久久久久下一站| 少妇特殊按摩高潮惨叫无码| 午夜免费无码福利视频|