在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human MMS19 nucleotide excision repair protein homolog (MMS19), partial

Recombinant Human MMS19 nucleotide excision repair protein homolog (MMS19), partial

  • 中文名稱：
    人MMS19重組蛋白
  • 貨號：
    CSB-YP836306HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MMS19重組蛋白
  • 貨號：
    CSB-EP836306HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MMS19重組蛋白
  • 貨號：
    CSB-EP836306HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MMS19重組蛋白
  • 貨號：
    CSB-BP836306HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MMS19重組蛋白
  • 貨號：
    CSB-MP836306HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MMS19
  • Uniprot No.：
  • 別名：
    hMMS19; homolog of yeast MMS19; MET18; MET18 homolog; MET18MMS19 nucleotide excision repair homolog (S. cerevisiae); mms19; MMS19 nucleotide excision repair protein homolog; MMS19 nucleotide excision repair, S. cerevisiae, homolog of; MMS19-like (MET18 homolog, S. cerevisiae); MMS19-like protein; MMS19_HUMAN; MMS19L
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

相關(guān)產(chǎn)品

靶點詳情

  • 功能：
    Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur (Fe-S) cluster assembly into ERCC2/XPD. Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
  • 基因功能參考文獻：
    1. findings suggest that MMS19 plays an essential role in maintaining mitochondrial genome stability PMID: 29035693
    2. POLE1 is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. PMID: 27235625
    3. We therefore propose the expression level of MMS19 as a candidate predictive marker of ACT benefit in resected NSCLC patients. PMID: 27802208
    4. Suggest that MMS19 may be a potential new predictor of metastasis and chemoradiotherapy response in esophageal squamous cell carcinoma. PMID: 25892874
    5. MMS19L polymorphisms are associated with response to chemotherapy in osteosarcoma. PMID: 23886164
    6. Single nucleotide polymorphisms in the MMS19L gene is associated with bone malignant tumors. PMID: 23679317
    7. Polymorphisms in ERCC1, codon-118 and MMS19 genes are not associated with clinical response to platinum or survival. PMID: 23632208
    8. MMS19 interacts with target proteins. MIP18 has a role to bridge MMS19 and CIAO1. CIAO1 also binds IOP1. PMID: 23585563
    9. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. PMID: 23150669
    10. study demonstrates MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1 and MIP18; cytoplasmic MMS19 also binds to multiple nuclear Fe-S proteins involved in DNA metabolism; propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair PMID: 22678361
    11. identified MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery; MMS19 functions as part of the CIA targeting complex that interacts with and facilitates iron-sulfur cluster insertion into apoproteins involved in methionine biosynthesis, DNA replication, DNA repair, and telomere maintenance PMID: 22678362
    12. Results indicate that the MMS19-XPD protein complex is required for proper chromosome segregation, an abnormality of which could contribute to the pathogenesis in some cases of xeroderma pigmentosum. PMID: 20797633
    13. Cloning of the human MMS19 genes and functional complementation in Saccharomyces cerevisiae PMID: 11328871
    14. MMS19 HEAT repeat domain is essential for MMS19 function in NER and transcription, while domains A and B, within MMS19 N-terminus, modulate the balance between DNA repair and transcription. PMID: 16797255
    15. Single nucleotide polymorphisms in MMS19L is associated with pancreatic cancer. PMID: 19318433

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    MET18/MMS19 family
  • 組織特異性：
    Ubiquitously expressed with higher expression in testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13824

    OMIM: 614777

    KEGG: hsa:64210

    STRING: 9606.ENSP00000359818

    UniGene: Hs.500721



主站蜘蛛池模板： 国产suv精二区| 国产 精品 自在 线免费| 日韩卡1卡2 卡三卡免费| 成人网站免费高清视频在线观看| 少妇激情一区二区三区视频| 狠狠躁夜夜躁人人爽天天不卡| 亚洲中文在线播放一区| 老汉老妇姓交视频| 婷婷射精av这里只有精品| 无码人妻精品一区二区三区99不卡 | 无码人妻精品一区二区三区99不卡 | 日本va欧美va精品发布| 成人综合婷婷国产精品久久| 国产一区二区三区四区精华| 久久精品亚洲中文无东京热| 欧美丰满熟妇bbbbbb百度| 与子敌伦刺激对白播放的优点| 久久久久久成人综合网| 狠狠噜天天噜日日噜视频麻豆| 唐人社导航福利精品| 视频在线+欧美十亚洲曰本| 亚洲国产一区二区精品无码| 精品少妇人妻av免费久久洗澡| 全黄h全肉边做边吃奶视频| 久久不见久久见www免费| 欧洲美熟女乱又伦av| 波多野结衣乳巨码无在线观看| 欧美两根一起进3p做受视频| 国产成人av区一区二区三| av电影在线观看| 天天色影网| 久久精品亚洲国产av老鸭网| 国产精品免费久久久久软件| 女人下边被添全过视频| 亚洲动漫精品无码av天堂| 国产成人av综合久久视色| 成人试看120秒体验区| 久久99精品久久久久久噜噜| 久久国内精品自在自线观看| 好大好硬好爽免费视频| 荡女精品导航|