在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human MAGUK p55 subfamily member 5 (MPP5)

  • 中文名稱:
    人MPP5重組蛋白
  • 貨號:
    CSB-YP847626HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人MPP5重組蛋白
  • 貨號:
    CSB-EP847626HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人MPP5重組蛋白
  • 貨號:
    CSB-EP847626HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人MPP5重組蛋白
  • 貨號:
    CSB-BP847626HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人MPP5重組蛋白
  • 貨號:
    CSB-MP847626HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    FLJ12615; MAGUK p55 subfamily member 5; Membrane protein palmitoylated 5; MPP 5; MPP5; MPP5_HUMAN; PALS 1; PALS1; Protein associated with Lin-7; Stardust (Drosophila); Stardust
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-675
  • 氨基酸序列
    MTTSHMNGHV TEESDSEVKN VDLASPEEHQ KHREMAVDCP GDLGTRMMPI RRSAQLERIR QQQEDMRRRR EEEGKKQELD LNSSMRLKKL AQIPPKTGID NPMFDTEEGI VLESPHYAVK ILEIEDLFSS LKHIQHTLVD SQSQEDISLL LQLVQNKDFQ NAFKIHNAIT VHMNKASPPF PLISNAQDLA QEVQTVLKPV HHKEGQELTA LLNTPHIQAL LLAHDKVAEQ EMQLEPITDE RVYESIGQYG GETVKIVRIE KARDIPLGAT VRNEMDSVII SRIVKGGAAE KSGLLHEGDE VLEINGIEIR GKDVNEVFDL LSDMHGTLTF VLIPSQQIKP PPAKETVIHV KAHFDYDPSD DPYVPCRELG LSFQKGDILH VISQEDPNWW QAYREGDEDN QPLAGLVPGK SFQQQREAMK QTIEEDKEPE KSGKLWCAKK NKKKRKKVLY NANKNDDYDN EEILTYEEMS LYHQPANRKR PIILIGPQNC GQNELRQRLM NKEKDRFASA VPHTTRSRRD QEVAGRDYHF VSRQAFEADI AAGKFIEHGE FEKNLYGTSI DSVRQVINSG KICLLSLRTQ SLKTLRNSDL KPYIIFIAPP SQERLRALLA KEGKNPKPEE LREIIEKTRE MEQNNGHYFD TAIVNSDLDK AYQELLRLIN KLDTEPQWVP STWLR
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells. Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface. Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity. Required during embryonic and postnatal retinal development. Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development. Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling. Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Plays a role in the T-cell receptor-mediated activation of NF-kappa-B. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton. Required for the normal polarized localization of the vesicular marker STX4. Required for the correct trafficking of the myelin proteins PMP22 and MAG. Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7.; (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity.
  • 基因功能參考文獻:
    1. Removal of this side chain enhances the binding affinity by more than fivefold, suggesting that access of Crb to Pals1 may be regulated by intradomain contacts or by protein-protein interaction. PMID: 25760605
    2. The unique in-frame MPP5-FAM71D fusion product is important for proliferation of PC346C cells. PMID: 24488012
    3. the crystal structure of a 4-L27 domain-containing heterotrimer derived from the tripartite complex Patj/Pals1/Mals2 PMID: 22337881
    4. Crystals of tripartite complex 1 of L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS) diffracted to 2.05 A resolution PMID: 22102253
    5. Small irregularly shaped spots are detected throughout the Pals1-deficient retina of conditional knockdown mice by confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography. PMID: 22114289
    6. The cell polarity protein PALS1 is expressed in T lymphocytes and participates to the optimal activation of NF-kappaB following TCR stimulation. PMID: 21479189
    7. Data suggest that hijacking of PALS1 by SARS-CoV E plays a determinant role in the disruption of the lung epithelium in SARS patients. PMID: 20861307
    8. Polycystin-2 activity is controlled by transcriptional coactivator with PDZ binding motif and PALS1-associated tight junction protein PMID: 20833712
    9. Polarity protein associated with lin seven 1 (Pals1) plays an essential role in radical and longitudinal extension of the myelin sheath in peripheral nerves, likely involving membrane protein trafficking. PMID: 20237282
    10. Pals1 functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. PMID: 11927608
    11. the Crumbs3-Pals1 complex has a role in development of polarity in mammalian epithelial cells PMID: 12771187
    12. PDZ domain plasticity has a role in internal recognition in the Par-6-Pals1 complex PMID: 15475968

    顯示更多

    收起更多

  • 亞細胞定位:
    Golgi apparatus. Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Cell projection, axon. Perikaryon. Apical cell membrane.; Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus.
  • 蛋白家族:
    MAGUK family
  • 組織特異性:
    Expressed at the outer limiting membrane in the retina (at protein level). Expressed in T lymphocytes (at protein level). Expressed in the kidney (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18669

    OMIM: 606958

    KEGG: hsa:64398

    STRING: 9606.ENSP00000261681

    UniGene: Hs.652312



主站蜘蛛池模板: 一二三四视频社区3在线高清| 亚洲人成电影在线观看影院| 国产精品女同一区二区| 久久精品日日躁夜夜躁欧美| 少妇被粗大的猛烈进出动视频| 国产大片黄在线观看私人影院| 欧美高清在线精品一区| 永久免费的无码中文字幕| 成人午夜无码精品免费看| 亚洲国产三级在线观看| 亚洲精品一区二区三区在线| 日韩插啊免费视频在线观看| 国产成人精品视频国产| 色诱视频在线观看| 亚洲免费人成在线视频观看| 亚洲国产午夜精华无码福利| 青青草无码精品伊人久久| 亚洲码欧美码一区二区三区| 欧美性猛交xxxx免费看| 国产免费人成视频在线播放播 | 国产精品久久久久影院色| 日本japanese丰满少妇| 99久久久无码国产精品古装 | 欧美丰满熟妇bbbbbb百度| 中文字幕无码毛片免费看| 国产美女口爆吞精普通话| 久久久久久av无码免费网站| 精品久久久久久无码专区不卡| 日产日韩亚洲欧美综合在线| 在线看免费无码av天堂的| 亚洲人成电影网站色www两男一女| 成人爱做日本视频免费| 国内丰满熟女出轨videos| 欧美人与物videos另类| 人禽杂交18禁网站免费 | 中文无码精品a∨在线观看不卡| 中文国产成人精品久久久| 熟妇人妻av中文字幕老熟妇| 小雪尝禁果又粗又大的视频| 日日天日日夜日日摸| 国产一区二区三区无码免费|