在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Lysine-specific demethylase NO66 (NO66)

  • 中文名稱:
    人RIOX1重組蛋白
  • 貨號:
    CSB-YP887992HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RIOX1重組蛋白
  • 貨號:
    CSB-EP887992HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人RIOX1重組蛋白
  • 貨號:
    CSB-EP887992HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RIOX1重組蛋白
  • 貨號:
    CSB-BP887992HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RIOX1重組蛋白
  • 貨號:
    CSB-MP887992HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RIOX1
  • Uniprot No.:
  • 別名:
    60S ribosomal protein L8 histidine hydroxylase; C14orf169; Chromosome 14 open reading frame 169 ; Histone lysine demethylase NO66; hsNO66; Hypothetical protein FLJ21802; Lysine-specific demethylase NO66; MAPJD; MYC associated protein with JmjC domain; NO66; NO66_HUMAN; Nucleolar protein 66; Ribosomal oxygenase NO66; ROX; Up regulated in lung cancer 2; URLC2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-641
  • 氨基酸序列
    MDGLQASAGP LRRGRPKRRR KPQPHSGSVL ALPLRSRKIR KQLRSVVSRM AALRTQTLPS ENSEESRVES TADDLGDALP GGAAVAAVPD AARREPYGHL GPAELLEASP AARSLQTPSA RLVPASAPPA RLVEVPAAPV RVVETSALLC TAQHLAAVQS SGAPATASGP QVDNTGGEPA WDSPLRRVLA ELNRIPSSRR RAARLFEWLI APMPPDHFYR RLWEREAVLV RRQDHTYYQG LFSTADLDSM LRNEEVQFGQ HLDAARYING RRETLNPPGR ALPAAAWSLY QAGCSLRLLC PQAFSTTVWQ FLAVLQEQFG SMAGSNVYLT PPNSQGFAPH YDDIEAFVLQ LEGRKLWRVY RPRVPTEELA LTSSPNFSQD DLGEPVLQTV LEPGDLLYFP RGFIHQAECQ DGVHSLHLTL STYQRNTWGD FLEAILPLAV QAAMEENVEF RRGLPRDFMD YMGAQHSDSK DPRRTAFMEK VRVLVARLGH FAPVDAVADQ RAKDFIHDSL PPVLTDRERA LSVYGLPIRW EAGEPVNVGA QLTTETEVHM LQDGIARLVG EGGHLFLYYT VENSRVYHLE EPKCLEIYPQ QADAMELLLG SYPEFVRVGD LPCDSVEDQL SLATTLYDKG LLLTKMPLAL N
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
  • 基因功能參考文獻:
    1. our findings clearly indicated that epigenetic regulation by NO66 plays an important role in cancer metastatic processes in CRC. PMID: 27473587
    2. confirmed the hydroxylase activity of NO66 and showed that oligomerization is required for NO66 to efficiently catalyze the hydroxylation of Rpl8 PMID: 26327385
    3. hinge domain-dependent oligomerization of NO66 is essential for inhibition of Osx-dependent gene activation. PMID: 23620590
    4. NO66 crystallized in space group P3(1) or P3(2), with unit-cell parameters a = 89.35, b = 89.35, c = 304.86 A, alpha = beta = 90, gamma = 120 degrees , and the crystal is likely to contain four molecules in the asymmetric unit PMID: 22750859
    5. interactions between NO66 and Osx regulate Osx-target genes in osteoblasts by modulating histone methylation states PMID: 19927124
    6. NO66 has functions in ribosome biogenesis and in the replication or remodeling of certain heterochromatic regions PMID: 14742713

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.
  • 蛋白家族:
    ROX family, NO66 subfamily
  • 組織特異性:
    Widely expressed. Overexpressed in lung carcinomas.
  • 數據庫鏈接:

    HGNC: 20968

    OMIM: 611919

    KEGG: hsa:79697

    UniGene: Hs.509916



主站蜘蛛池模板: 色一情一乱一伦一区二区三区| 久久不见久久见免费视频7 | 男女猛烈无遮挡免费视频| 亚裔大战黑人老外av| 中文日韩亚洲欧美制服| 色婷婷综合和线在线| 国产精品自在线拍亚洲另类| 亚洲另类激情综合偷自拍图| 少女韩国电视剧在线观看完整| 曰韩欧美群交p片内射| 国产精品无码一区二区牛牛| 四虎av永久在线精品免费观看| 国内精品久久久久久中文字幕| 午夜福利片手机在线播放| 伊人色综合网久久天天| 女人另类牲交zozozo| 夜爽8888视频在线观看| 色噜噜亚洲男人的天堂| 久久只精品99品免费久23| 欧美成人片在线观看| 中文幕无线码中文字夫妻| 中文字幕一区二区精品区| 亚洲色爱图小说专区| 少妇特黄a一区二区三区 | 天天做天天爱夜夜爽| 永久免费的av在线电影网| 亚洲成年看片在线观看| 亚洲乱妇老熟女爽到高潮的片| 大肉大捧一进一出好爽动态图| 麻豆熟妇人妻xxxxxx| 2021久久最新国产精品| 粉嫩av久久一区二区三区| 狠狠色噜噜狼狼狼色综合久| 亚洲综合欧美制服丝袜| 日本高清成本人视频一区| 国产乱色精品成人免费视频| 狠狠久久噜噜熟女| 思思久久精品一本到99热| 人人人妻人人澡人人爽欧美一区| 中日韩高清无专码区2021| 国内午夜国产精品小视频|