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  4. Recombinant Human Lysine-specific demethylase 5D (KDM5D), partial

Recombinant Human Lysine-specific demethylase 5D (KDM5D), partial

  • 中文名稱：
    人KDM5D重組蛋白
  • 貨號：
    CSB-YP863151HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KDM5D重組蛋白
  • 貨號：
    CSB-EP863151HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KDM5D重組蛋白
  • 貨號：
    CSB-EP863151HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KDM5D重組蛋白
  • 貨號：
    CSB-BP863151HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KDM5D重組蛋白
  • 貨號：
    CSB-MP863151HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KDM5D
  • Uniprot No.：
  • 別名：
    H-Y; Histocompatibility Y antigen; Histone demethylase JARID1D; HY; HYA; JAD1D; Jumonji AT rich interactive domain 1D (RBP2 like); Jumonji/ARID domain-containing protein 1D; KDM5D; KDM5D_HUMAN; KIAA0234; Lysine (K) specific demethylase 5D; Lysine demethylase 5D; Lysine-specific demethylase 5D; Protein SmcY; Selected mouse cDNA on Y human homolog of; SMC homolog Y chromosome; Smcy homolog Y linked
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.
  • 基因功能參考文獻：
    1. Loss of KDM5D expression leads to docetaxel resistance in prostate cancer. PMID: 27185910
    2. The expression profiles of KDM5D isoforms were investigated in prostate cancer cell lines along with their gene regulatory network. PMID: 26728332
    3. study identifies JARID1D as an anti-invasiveness histone methylation modifier that acts against prostate cancer cell metastasis by repressing metastatic gene programs; results also highlight a preclinical rationale for using JARID1D as a prognostic marker in advanced prostate cancer PMID: 26747897
    4. Of 820 proteins present in all four replicates of two treatments, the abundance of 209 proteins changed significantly in response to KDM5D suppression PMID: 26215926
    5. The presence of H-Y antibodies correlated with chronic graft-versus-host disease PMID: 15613541
    6. HY-specific CD8+ T cells also could be detected directly in the peripheral blood of women with a history of at least two pregnancies that produced males. PMID: 16988213
    7. Study shows that JARID1d and MBLR occupy human Engrailed 2 gene and regulate its expression and histone H3 lysine 4 methylation levels. PMID: 17320162
    8. Results suggest that SMCY may have a male-specific function as a histone H3K4 demethylase by recruiting a meiosis-regulatory protein to condensed DNA. PMID: 18459961
    9. HY-restricting HLA class II alleles is associated with pregnancy outcome in patients with recurrent miscarriage subsequent to firstborn boys. PMID: 19223392
    10. compared with other recipient-donor gender combinations, female recipients of male donor kidney transplants in the United States have an increased short-term risk but not long-term risk for adverse outcomes PMID: 19541808

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    JARID1 histone demethylase family
  • 組織特異性：
    Expression is highly down-regulated in metastatic prostate tumors.
  • 數據庫鏈接：

    HGNC: 11115

    OMIM: 426000

    KEGG: hsa:8284

    STRING: 9606.ENSP00000444293

    UniGene: Hs.80358



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