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  4. Recombinant Human Leucine zipper putative tumor suppressor 2 (LZTS2)

Recombinant Human Leucine zipper putative tumor suppressor 2 (LZTS2)

  • 中文名稱：
    人LZTS2重組蛋白
  • 貨號：
    CSB-YP874792HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LZTS2重組蛋白
  • 貨號：
    CSB-EP874792HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LZTS2重組蛋白
  • 貨號：
    CSB-EP874792HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LZTS2重組蛋白
  • 貨號：
    CSB-BP874792HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LZTS2重組蛋白
  • 貨號：
    CSB-MP874792HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    LZTS2
  • Uniprot No.：
  • 別名：
    LZTS2; KIAA1813; LAPSER1; Leucine zipper putative tumor suppressor 2; hLZTS2; Protein LAPSER1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-669
  • 氨基酸序列
    MAIVQTLPVP LEPAPEAATA PQAPVMGSVS SLISGRPCPG GPAPPRHHGP PGPTFFRQQD GLLRGGYEAQ EPLCPAVPPR KAVPVTSFTY INEDFRTESP PSPSSDVEDA REQRAHNAHL RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP VLPKPRGAPS LPSFMGPRAT GLSGSQGSLT QLFGGPASSS SSSSSSSAAD KPLAFSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTT SSPGGHLPSH GSGRGALPGP ARGVPTGPSH SDSGRSSSSK STGSLGGRVA GGLLGSGTRA SPDSSSCGER SPPPPPPPPS DEALLHCVLE GKLRDREAEL QQLRDSLDEN EATMCQAYEE RQRHWQRERE ALREDCAAQA QRAQRAQQLL QLQVFQLQQE KRQLQDDFAQ LLQEREQLER RCATLEREQR ELGPRLEETK WEVCQKSGEI SLLKQQLKES QAELVQKGSE LVALRVALRE ARATLRVSEG RARGLQEAAR ARELELEACS QELQRHRQEA EQLREKAGQL DAEAAGLREP PVPPATADPF LLAESDEAKV QRAAAGVGGS LRAQVERLRV ELQRERRRGE EQRDSFEGER LAWQAEKEQV IRYQKQLQHN YIQMYRRNRQ LEQELQQLSL ELEARELADL GLAEQAPCIC LEEITATEI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
  • 基因功能參考文獻：
    1. LZTS2 promoter hypermethylation is associated with laryngeal squamous cell carcinoma. PMID: 29499699
    2. LZTS2 could inhibit cell proliferation and cell cycle transition at the G1/S phase and was implicated in the regulation of proteins associated with the canonical Wnt pathway, including GSK3B and beta-catenin through inactivating the Akt pathway. PMID: 23761130
    3. deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development. PMID: 23275340
    4. LZTS2 is a beta-catenin-interacting protein and modulates beta-catenin signaling and localization PMID: 17000760
    5. The reciprocal crosstalk between beta-catenin/Tcf pathway and NF-kappaB signaling in hMSCs is mediated through the regulation of lzts2 expression. PMID: 17950943
    6. LAPSER1 C terminal domain inhibits katanin(p80/p60)-mediated microtubule severing in vitro. PMID: 18490357

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
  • 蛋白家族：
    LZTS2 family
  • 組織特異性：
    Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.
  • 數據庫鏈接：

    HGNC: 29381

    OMIM: 610454

    KEGG: hsa:84445

    STRING: 9606.ENSP00000359240

    UniGene: Hs.523221



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