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  4. Recombinant Human Leucine-rich repeats and immunoglobulin-like domains protein 3 (LRIG3), partial

Recombinant Human Leucine-rich repeats and immunoglobulin-like domains protein 3 (LRIG3), partial

  • 中文名稱：
    人LRIG3重組蛋白
  • 貨號：
    CSB-YP751017HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LRIG3重組蛋白
  • 貨號：
    CSB-EP751017HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LRIG3重組蛋白
  • 貨號：
    CSB-EP751017HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LRIG3重組蛋白
  • 貨號：
    CSB-BP751017HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LRIG3重組蛋白
  • 貨號：
    CSB-MP751017HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    LRIG3
  • Uniprot No.：
  • 別名：
    Leucine-rich repeats and immunoglobulin-like domains protein 3; Leucine-rich repeats- and immunoglobulin-like domains- containing protein 3; LIG-3; LIG3; LRIG1-3; Lrig3; LRIG3_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1.
  • 基因功能參考文獻：
    1. Role of LRIG3 in cancer [review] PMID: 27628597
    2. This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans. PMID: 26517670
    3. LRIG3 functions as a tumor suppressor by attenuating EGFR signaling pathway. PMID: 25708990
    4. LRIG3 plays an important role in Hela229 cell proliferation, apoptosis, and invasiveness. PMID: 26390694
    5. The results on expression of other tumor markers suggest that LRIG3 is influenced by or influences a pattern of tumor markers in cancer and precancerous cells. PMID: 24998916
    6. In conclusion, the over-expression of LRIG3 could influence the cell cycle and invasion, inhibit proliferation and induce apoptosis in the three bladder cancer cell lines. PMID: 23392718
    7. Data indicate that Lrig3 opposes Lrig1 negative regulatory action and enhances ErbB receptors ERBB2, ERBB3 and ERBB4 stability. PMID: 23723069
    8. High LRIG3 expression is associated with cervical adenocarcinoma progression. PMID: 23165628
    9. Silencing LRIG3 inhibited the proliferation and promoted the apoptosis of bladder cancer T24 cells. PMID: 21505989
    10. siRNA targeting LRIG3 gene shows a dramatic inhibitory effect on RNA transcription and protein expression, then promotes the proliferation and suppresses apoptosis of GL15 cells. PMID: 19224171
    11. These results indicate that expression and sub-cellular localization of LRIG1-3 might be of importance in the pathogenesis and prognosis of astrocytic tumors. PMID: 16532360
    12. Down-regulation of LRIG3 in HP75 pituitary adenoma is reported. PMID: 17393120
    13. LRIG proteins may have a role in epidermal homeostasis and psoriasis PMID: 18037903
    14. LRIG3 may be involved in the regulation of EGF receptor signaling, and serve as a tumor suppressor gene in the pathogenesis of glioma. PMID: 19200647
    15. the expression of LRIG1-3 was evaluated in 51 human ependymomas and was found to be more highly expressed in supratentorial than in infratentorial ependymomas PMID: 19216216
    16. Down-regulating LRIG3 gene expression can improve the proliferation of glioma GL15 cells. PMID: 19448407

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 30991

    OMIM: 608870

    KEGG: hsa:121227

    STRING: 9606.ENSP00000326759

    UniGene: Hs.253736



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