在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1), partial

  • 中文名稱:
    人LRRFIP1重組蛋白
  • 貨號:
    CSB-EP013175HU
  • 規(guī)格:
    ¥1272
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    LRRFIP1
  • Uniprot No.:
  • 別名:
    FLAP 1; FLAP1; FLIIAP 1; FLIIAP1; GC binding factor 2; GC-binding factor 2; GCF 2; GCF2; HUFI 1; HUFI1; Leucine rich repeat (in FLII) interacting protein 1; Leucine rich repeat flightless interacting protein 1; Leucine-rich repeat flightless-interacting protein 1; LRR FLII interacting protein 1; LRR FLII-interacting protein 1; LRRF1_HUMAN; LRRFIP 1; Lrrfip1; MGC10947; MGC119738; MGC119739; NEDD8 conjugating enzyme; TAR RNA interacting protein; TAR RNA-interacting protein; Transcription factor 9 like; TRIP
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial of Isoform 3
  • 來源:
    E.coli
  • 分子量:
    40.1kDa
  • 表達區(qū)域:
    1-314aa
  • 氨基酸序列
    MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRASEVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLGTLAGATYEEQSLSTCSLDR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
  • 基因功能參考文獻:
    1. Results show that LRRFIP-1 is mainly produced by keratinocytes in the unwounded skin but is upregulated in both keratinocytes and fibroblasts in response to wounding, suggesting a role in the wound repair process. PMID: 29996558
    2. Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/beta-catenin signaling pathway. PMID: 26047573
    3. High GCF2 expression is associated with hepatoma. PMID: 24761896
    4. Higher baseline LRRFIP1 expression in human glioblastoma multiforme tissue (n=60) is associated with better prognosis upon later treatment with teniposide. PMID: 24690174
    5. Data indicate that LRRFIP1 knockdown increased resting TNF mRNA level altered the ncRNA abundance at the LRRFIP1 binding region. PMID: 24567534
    6. Eight SNPs (rs7575941, rs3769053, rs11689421, rs3820808, rs11680012, rs3806505, rs6739130, and rs11686141) showed evidence of association with at least two adiposity phenotypes and plasma levels of one marker of inflammation. PMID: 23505185
    7. The FLI-interacting domain of LRRFIP1 forms a classic parallel, homodimeric coiled coil with 10 heptad repeats and 22 helical turns. PMID: 23099021
    8. GCF2/LRRFIP1 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion. PMID: 22750095
    9. LRRFIP1 is phosphorylated in response to immunologic stimuli and it is directed to lysosomal structures. PMID: 21102652
    10. An association study of 6 of the 63 genes in 4235 cases and 6379 controls showed a putative association with myocardial infarction for COMMD7 (COMM domain-containing protein 7) and a major deviation from the null hypo thesis for LRRFIP1. PMID: 20833976
    11. GCF2/LRRFIP1 appears to act as a repressor and occupies the -308 site in cells that do not make TNF-alpha. PMID: 16199883
    12. Immediately following lipopolysaccharide stimulation, both LRRFIP2 and Flap-1/LRRFIP1 compete with Fliih for interacting with MyD88 to activate the signaling. PMID: 19265123

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    LRRFIP family
  • 組織特異性:
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6702

    OMIM: 603256

    KEGG: hsa:9208

    STRING: 9606.ENSP00000375857

    UniGene: Hs.471779



主站蜘蛛池模板: 亚洲超清无码制服丝袜无广告| 久久久久国产a免费观看rela| 精品人妻无码一区二区色欲产成人| 无码人妻aⅴ一区二区三区 | 四房播色综合久久婷婷| 亚洲大尺度专区无码浪潮av| 国产又黄又爽又色的免费视频 | 九九九精品成人免费视频小说| 欧美黑人xxxx高潮猛交| 日韩精品人妻系列无码专区免费| 无码人妻丰满熟妇啪啪7774| 老汉色老汉首页a亚洲| av无码欧洲亚洲电影网| 人妻大战黑人白浆狂泄| 换脸国产av一区二区三区| 久久国产欧美成人网站| 美女视频黄频a美女大全| 国产成人免费爽爽爽视频| 国产成人无码免费视频麻豆| 国产aⅴ精品一区二区三区| 伊伊人成亚洲综合人网7777| 欧美变态暴力牲交videos| 国产又粗又黄又爽的大片| 国产精品美女久久久久av爽李琼| 朝鲜美女黑毛bbw| 亚洲日韩久热中文字幕| 尤物蜜芽国产成人精品区| 久久精品国产一区二区三区不卡| 扒开双腿吃奶呻吟做受视频 | 久久综合97丁香色香蕉| 欧美另类bbbxxxxx另类| 久久久精品国产免大香伊| 国色天香天天影院综合网| 护士av无码在线观看| 国产午夜福利视频在线观看| 无遮无挡三级动态图| 无码人妻久久1区2区3区| 国产人妻久久精品二区三区老狼| 99久久婷婷国产综合精品电影| 天堂aⅴ无码一区二区三区| 欧美精品黑人粗大免费|